Immune

By Vincent Racaniello

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Subscribers: 121
Reviews: 1

Reed
 May 29, 2019
An in depth podcasts with immunologist hosts diving deeply into interesting papers and answering listener questions. I like all the hosts, they do their best to explain all the immunology jargon, they are funny and passionate.

Description

A podcast about the body's defenders against disease.

Episode Date
Immune 33: COVID-19 immunotypes
01:23:57

Immune explains a study of 125 COVID-19 patients by deep immune profiling, which revealed three immunotypes associated with poor clinical prognosis or recovery.

Hosts: Vincent Racaniello and Cynthia Leifer

Guest: Brianne Barker

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Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Jul 28, 2020
Immune 32: Immunology of COVID-19, part four
01:30:33

Immune continues a discussion of the immune response to infection with SARS-CoV-2, including inflammatory responses and disease, antibody and T-cell responses, and vaccines, and answers to listener questions.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Brianne Barker

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Music by Steve Neal. Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Jun 05, 2020
Immune 31: Immunology of COVID-19, part three
01:30:05

Immune continues a discussion of the immune response to infection with SARS-CoV-2, including vaccines and immunity, effects of BCG and OPV, immunity passports, and answers to listener questions.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Brianne Barker

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Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

May 08, 2020
Immune 30: Immunology of COVID-19, part two
01:23:27

Brianne Barker returns to continue a discussion of the immune response to infection with SARS-CoV-2, including use of steroid, coagulation in some patients, cytokine storm, and vaccines.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Brianne Barker

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Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Apr 17, 2020
Immune 29: Immunology of COVID-19
01:26:56

Brianne Barker joins Immune to discuss the immune response to infection with SARS-CoV-2, including immune respones, pathogenesis, immunopathology and more.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Brianne Barker

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Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Mar 31, 2020
Immune 28: Fish immunology
56:31

Irene Salinas joins Immune to reveal the work of her laboratory on the evolution of mucosal immune responses in teleost fish, the oldest living bony vertebrates.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Irene Salinas

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Music by Steve Neal. Immune logo image by Blausen Medical.

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Feb 08, 2020
Immune 27: Trained immunity
01:33:55

Steph explains how sepsis induces protective immune memory in NK cells, via histone methylation of the interferon gamma enhancer.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Jan 11, 2020
Immune 26: Measles erases immune memory
01:37:33

Michael Mina joins the Immune team to explain his findings that measles diminishes pre-existing antibodies that protect against infection with other pathogens.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Michael Mina

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Music by Steve Neal. Immune logo image by Blausen Medical.

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Nov 28, 2019
Immune 25: Remembrance of antigen encounters past
01:22:29

The Immune team explains that short chain fatty acids produced by microbial fermentation of fiber rewire metabolism to enable the production of memory T cells.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Weekly Science Picks

Stephanie - This Week in Neuroscience
Cindy - Graduate Abuse by Derek Lowe
Vincent - Funding ends for seeking new viruses

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Nov 01, 2019
Immune 24: Unlucky IL-13
01:29:23

The Immune team reveals a new type of T helper cell that drives the production of IgE, leading to allergic responses.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Weekly Science Picks

Cindy- Lasker Award 2019
Vincent- Eleanor's Breakthrough video

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Sep 19, 2019
Immune 23: How to tell a mouse from a mouse
01:27:12

The immunosomes explain that widely used inbred laboratory mice are not identical, and how to tell them apart.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Weekly Science Picks

Steph- University of Alaska budget crisis
Cindy- 90% survival following new Ebolavirus treatments
Vincent- Immunology videos at Blausen Medical

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Aug 14, 2019
Immune 22: Engineering B cells
01:18:23

Immune reveals an alternative to a protective vaccine, engineered B cells that produce antiviral antibodies.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Weekly Science Picks

Steph- Breath of fresh air
Cindy- Biologist found dead
Vincent- Nobel Prizes and Nature’s Surprises by Erling Norrby

Music by Steve Neal. Immune logo image by Blausen Medical.

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Jul 31, 2019
Immune 21: Islets of Langelhans
01:27:17

Immune tackles the finding that patients with Type I diabetes have lymphocytes with both TCR and BCR that may drive the pathogenesis of the disease.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Weekly Science Picks

Steph- Unique Scientists
Cindy- Researcher app
Vincent- STLR Conversations Podcast

Music by Steve Neal. Immune logo image by Blausen Medical.

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Jun 12, 2019
Immune 20: In defense of death
01:28:11

The Immune trio explains how activation of the inflammasome by a bacterial protein causes blood clotting through a programmed cell death process called pyroptosis.

 

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Weekly Science Picks

Steph- iBiology Immunology Course
Cindy- Changing vaccine hesitancy
Vincent- Bad Advice by Paul Offit (and Vaccines and Your Child)

Listener Pick

Steve- An Elegant Defense

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

May 29, 2019
Immune 19: Mom's the word
01:16:33

The Immune team discusses immunization of pregnant mice to protect offspring from neonatal herpes simplex virus disease.

 

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Weekly Science Picks

Steph- iNaturalist
Cindy- Taking a break is also hard work
Vincent- Immunology Wall Posters

Music by Steve Neal. Immune logo image by Blausen Medical.

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Apr 17, 2019
Immune 18: Biting off more TCR than you can chew
01:20:35

The immunophiles discuss T cell antigen discovery by trogocytosis - the transfer of membrane patches among cells in close contact.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Weekly Science Picks

Steph- Scientists rise up against statistical significance
Cindy- Why I quit my PhD and returned
Vincent- The Law and Vaccine Resistance

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Mar 27, 2019
Immune 17: Feed a macrophage, starve a tumor
01:08:23

The immunophiles explain how metabolic rewiring of macrophages by CpG promotes clearance of cancer cells.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Weekly Science Picks

Steph- Pregnant Scholar
Cindy- Anti-vaxxers vaccinating against measles
Vincent- Center for Science in the Public Interest

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Feb 13, 2019
Immune 16: B is for Bursa
01:12:43

The Immune team turns to chickens, which have been important in understanding the immune system, to show that infection of mature B cells is not required for the pathogenesis of Marek's disease herpesvirus.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Weekly Science Picks

Steph - 7 Days Out
Cindy - Watson PBS documentary and Cold Spring Harbor Laboratory response
Vincent - Dads can donate mitochondrial DNA and Chicken puns

Jan 19, 2019
Immune 15: Happy neu-trophil year
01:26:27

Stephanie takes the Immune team on a tour of neutrophils, the most abundant leukocytes in mammals, including tethers and slings, neutrophil rolling, and neutrophil nets.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Weekly Science Picks

Steph- Should reviewers remain anonymous?
Cindy- Breast Cancer Research Foundation
Vincent- Initiative to End Paywalls (The Scientist)

Music by Steve Neal. Immune logo image by Blausen Medical.

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Dec 22, 2018
Immune 14: Braking bad
01:20:17

The Immune team explains the science behind the 2018 Nobel Prizes awarded to Allison and Honjo: checkpoint immunotherapy.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Weekly Science Picks

Steph- Immunobites
Cindy- List of immunology Nobels
Vincent- Prof. Barker's Immunology lectures

Music by Steve Neal. Immune logo image by Blausen Medical.

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Nov 14, 2018
Immune 13: Do no harm
01:17:01

The ImmuNerds discuss how a cellular long non-coding RNA binds to an innate RNA sensor and regulates virus-induced interferon production to prevent damage to the host.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Weekly Science Picks

Steph- That's Pediatrics Podcast
Cindy- Trilobite Glassworks
Vincent- Research!America

Music by Steve Neal. Immune logo image by Blausen Medical.

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Oct 20, 2018
Immune 12: Systems immunology
01:11:39

The Immune trifecta explores systems immunology, and its use in a study of immune system development in newborn children.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Weekly Science Picks

Steph- Kaleidoscopean
Cindy- 500 women scientists
Vincent- NIH budget increase 2019

Music by Steve Neal. Immune logo image by Blausen Medical.

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Sep 19, 2018
Immune 11: Immunomimetic designer cells
01:08:33

Cindy and Vincent describe the construction of a gene network that programs mammalian cells to detect and eliminate bacterial infections.

Hosts: Vincent Racaniello and Cynthia Leifer

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Science Picks

Cindy - No Tdap link to autism
Vincent
- Unpaywall

Music by Steve Neal. Immune logo image by Blausen Medical.

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Aug 18, 2018
Immune 10: Immune goes viral
01:15:39

The Immune team travels to the University of Maryland for ASV 2018, where they meet up with Rebecca Lynch to explore her work on broadly neutralizing antibodies against HIV-1.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Guest: Rebecca Lynch

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Jul 21, 2018
Immune 9: Neither mice nor lamprey lie
01:35:11

The Immune team explores the variable lymphocyte receptors of jawless vertebrates, a system of immunity that parallels the structurally unrelated antibodies of jawed vertebrates.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Weekly Science Picks

Steph- Jon Yewdell on TWiV (208, 467)
Cindy- No polio in Venezuela
Vincent- Is gaming addiction a thing?

Music by Steve Neal. Immune logo image by Blausen Medical.

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Jun 20, 2018
Immune 8: Staying warm with γδ T cells
01:19:29

The Immune team reveals how γδ T cells that synthesize interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Weekly Science Picks

Steph- Polycystic ovary syndrome and anti-Mullerian hormone
Cindy- Foldscope(Ted talk)
Vincent- Virology Lectures 2018

Music by Steve Neal. Immune logo image by Blausen Medical.

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May 25, 2018
Immune 7: Contradictory complements in Alzheimer's disease
01:13:05

The Immune hosts discuss how the complement system functions, and its role in early synapse loss in a mouse model of Alzheimer's disease.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Apr 18, 2018
Immune 6: Potent antiviral antibodies without somatic mutation
01:29:03

The Immune hosts explain how antibody molecules mature, then discuss the finding in infants of potent neutralizing antibodies against respiratory syncytial virus without somatic hypermutation.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Weekly Science Picks

Steph - REACTOME project (free icons)
Cindy - Gender Imbalance in Stories
Vincent - Trump, Tell Us About Your Flu Shot

Music by Steve Neal. Immune logo image by Blausen Medical.

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Mar 16, 2018
Immune 5: Mother knows best about food allergies
01:40:57

The ImmuoModulators provide a primer on mucosal defenses, and explain how sensitizing female mice to food allergens prevents allergic reactions in their offspring.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Music by Steve Neal. Immune logo image by Blausen Medical.

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Feb 22, 2018
Immune 4: Putting the immunotherapy CAR T before the cancer
01:23:15

The immu-knowledge-ists deconstruct the holy grail of oncologists, cancer immunotherapy, and the exciting development of CAR T cells and how they work.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Weekly Science Picks

Cindy - What's In A Name?
Steph
- Novel Targets
Vincent - Friendly Penguin

Music by Steve Neal. Immune logo image by Blausen Medical.

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Jan 23, 2018
Immune 3: Two epitopes, four serotypes, and a partridge in a pear tree
01:19:15

Cindy, Steph, and Vincent discuss recent problems with dengue virus vaccine, and a bi-specific monoclonal antibody against Zika virus.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Weekly Science Picks

Cindy - Questions answered about starving polar bear video
Steph
- Deep Work by Cal Newport and Grad Student Tax
Vincent - Making art with Excel

Music by Steve Neal. Immune logo image by Blausen Medical.

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Dec 16, 2017
Immune 2: Lymphocytes after dark
01:26:55

Cindy, Steph, and Vincent reveal that lymphocyte trafficking through lymph nodes and lymph are circadian - it is dependent on the time of day.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Weekly Science Picks

Cindy - Men ask more questions than women at a scientific conference (PLoS One)
Steph
- House just voted to bankrupt graduate students
Vincent - Trump's Legacy: Damaged Brains

Music by Steve Neal. Immune logo image by Blausen Medical.

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Nov 25, 2017
Immune 1: Some like it hot
01:05:31

Cindy, Steph, and Vincent launch a new podcast, Immune, and reveal how warm temperature protects against atherosclerosis by regulating monocyte migration into the blood.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Weekly Science Picks

Cindy - FDA approves second CAR T cell therapy
Steph
- Gammaherpesvirus protects against asthma
Vincent - Truth Wins by Jonathan Yewdell

Intro music is by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Oct 31, 2017