In this episode we continue on the path of DIC: the scary sub-phenotype that is Purpura Fulminans. When your patient is necrosing everything, you need to act quickly before they start losing organs and digits. Come listen for identification, anticoagulation, protein C and all its goodness, when to give Vitamin K, and why to really be careful about Warfarin.

In this episode, we cover disseminated intravascular coagulation. It sounds bad, because it is. Come listen and refresh your skills around supporting the bleed-bleedy versus the cloth-clotty, how to differentiate DIC and chronic liver failure and a few more juicy clinical pearls.

In this episode, we cover the spectrum of lithium toxicity, from the acute ingestion, to the patient with saturated brain tissue. Come take a listen to explore the nuances around volume repletion, when or should you reach for dialysis, what SILENT is or does it exist.

In this episode we cover those super antigens that cause all the trouble with staph and strep infections. Come take a listen around pathophysiology, identification, antimicrobials and all things IVIG.

In this episode, we cover the OG-Farkas description of the age-old interplay between bradycardia / renal failure / AV nodal blocking agent / Shock / and Hyperkalemia. Don't just try and snipe one off at a time, carpet bomb them all at once. 

In this episode we cover the crucial approach to what drives hemorrhagic shock: lots of bleeding. Come take a listen for the nuances around an organized approach to 1:1:1 and may we be as bold to say... 1:1:1:1 (fibrinogen, YAY). All things hypocalcemia, hypothermia, acidosis and what lines to use. 

We were actively trying to fill your life with non-covid things... but we just had to talk about these big new things. Come take a listen of aerosol transmission, why Remdesivir just doesn't work in the real world, why not to make the same mistake with the -mab du jour, and a few other tid bits.

In this episode, we cover that daily issue: Is this a VAP? Come take listen to level up beyond leukocytosis, inflammation, consolidation, worsening oxygenation and positive cultures.

Viva la Piptazo - Linezolid/Vanco diad.

In this episode, we cover another great white whale in critical care: Hemophagocytic LymphoHistiocytosis (HLH). When your macrophages turn into paceman and start chomping your own cells, you're in trouble. Com listen about genetic predisposition to unchecked immune response, and a conversation around immunomodulation.

In this episode we cover the big picture view of ileus, gastroparesis and colonic pseudo-obstruction. Come take a listen so summarize these issues you will encounter on the daily.

In this episode, we cover the DVT of the Brain... Cerebral Venous Thrombosis. Lace up your shoes, start washing those dishes, do whatever you need to do while we remind you about presentation, workup and most of all, treatment. As 1% of all strokes and the most common cause of stroke in young patients, you'll want to know this one cold.

In this episode we cover the often overlooked topic of glycemic control in the ICU. What blood sugar should we be targeting? Is that hyperglycaemia a stress response? Insulin resistance? Iatrogenic? All of the above. Come listen to our discussion, and Josh's attempt at clearing up a confused evidence base.

We've reached a milestone, 100 episodes! In this podcast, we cover ICU level thiamine deficiency, not just your white-whale of Wernicke encephalopathy. Come take a listen for dosing, clinical features and complications.

In this episode, we cover the approach to the   not-so-rare cause of ICU level pancreatitis: hypertriglyceridemia. Come take a listen for nuances around insulin management, and second thoughts around using heparin and plasmapheresis.

In this episode we simplify the approach to covering your invasive fungal infections in critically unwell patients. 

Yeast vs Mold vs Endemic Mycoses

Azoles vs Echinocandins vs Amphotericin

Its the rare occasion you go one complete day without treating Nausea and vomiting in the ICU. In this episode, we cover the ddx you can't miss, and the multiple receptors to target in your patients.

In this episode, we cover the essentials of analgesia for your critically ill patients. Spoiler alert, multimodal approaches are the way to go. If your MAR only has opiates on it, there may be a problem. 

Come listen for a new twist on the ladder approach, all things ketamine / precedes and lidocaine... with much much more.

In this episode we cover the widely use, but poorly supported inhaled pulmonary vasodilators:

-Oxygen

-Nitroglycerin / Nitric Oxide

-Epoprostenol

-Milrinone

In this episode, we cover the more sinister twin of DKA... HONK aka HHS (Hyperosmolar Hyperglycemic State).

Come listen to how not to blow up your patients brain in the tug-of-war between glucose and sodium.

In this episode we cover Guillain-Barre Syndrome. Everything from presentation, to why you should stop checking negative inspiratory pressure and just stick with FVC. Read the post then come take a listen.

In this episode we cover one of the most fatal and moribund conditions we see regularly, Intracranial hemorrhage.

Etiology, diagnosis and treatment (of course we spend time on BP goals).

In this episode we cover Catastrophic Antiphospholipid Syndrome. A very rare and often missed diagnosis. Come take a listen to brush up on high risk patient population, clinical diagnosis, labs, steroids / anticoagulation and more treatment options.

In this episode we talk about fever... fever in the ICU... ICU acquired fever. It is not all VTE or VAPS, Chole or CLABSI. We cover a thoughtful approach to not just sending pan culture, and adding piptazo-vanco.

In this episode, we cover the sasquatch of ICU derived fever: catheter associated urinary track infection. Farkas is on the fence whether it is clinically relevent:

Come listen for those pearls: IDSA diagnostic criteria. Treatment coverage. Purple bag syndrome, and more!

In this episode we cover a major cause of mortality for our sickle cell patients: Acute Chest Syndrome. This is a very serious entity you must keep a low clinical threshold for working up and treating.

Diagnosis

Pain Control, Volume Resuscitation

Antimicrobials

Exchange transfusions and more

In this episode, we cover the rare but life threatening Epiglottitis. 

Highlights:

Presentation not as you learned in medical school

Vast majority do not need intubation, but for those that due it can be catastrophic

Nasolaryngoscopy, Steroids, broad spectrum antibiotics and early airway plans are the way to go

In this episode, we cover ICU level Pneumocystic Jirovicii Pneumonia (previously known as Pneumocystic Carinii Pneumonia).

Suggested approach:

HIV +(ve) vs HIV -(ve)

Invasive vs Non invasive diagnostic strategy

Treatment w. Septra vs other line therapies

In this episode, we cover the lesser of evil stridor aetiologies: Vocal cord dysfunction, a.k.a paradoxical vocal cord motion, a.k.a Paradoxical Vocal Fold Movement. Read the post, then listen to review approach, diagnostic modalities (fibre-optic visualization, CT scan to rule out other entities) and treatment.

Come get acquinted with the two forms: angioinvasive (think neutropenia) vs bronchoinvasive (the not so immunosuppressed). Don't forget to add this to your Ddx for nosocomial post-influenza & COVID-19.

In this episode we cover the often overlooked entity that is re-feeding syndrome.

High Risk populations

Signs & Symptoms

Insulin mediated edema, and more

In this episode, we cover the presentation, clinical signs / symptoms and workup of takotsubo cardiomyopathy. Come take a listen so you'll never miss that octopus-trap of a clinical confounder, with juicy pearls around LVOT obstruction.

In this episode we cover the work horses we use daily in critical care patients: anticoagulants: Unfractionated heparin (UFH), LMWH, fondaparinux, argatroban, and bivalirudin. We also cover BID dosing of LMWH prophylaxis and the essential section here is on heparin resistance. Enjoy!

In this episode, we cover that bread and butter presentation, chronic obstructive pulmonary disease.

Clinical Features

Respiratory support

Pharmacotherapy

Approach to ventilation and extubation

In this episode we update therapeutics: Kaletra is back. Before/after for Steroids. Anakinra is here. We also delve into coagulopathy and super spreaders.

In this Episode:

We update new understandings from NYC, Lung pathology (AFOP), Cowboys Vs Ivory Towers, Remdesivir and COVID-19 Phenotypes.

Stay Healthy!

In this update:

The Fall of Remdesivir?

HCQ no so bueno?

Fluid status

Learning from Tobin, Gattinoni, and our patients physiology

Steroids!?!?

In our 3rd installment of correcting things we've said that were wrong 🤓, here we cover COVID-19 coagulopathy, respiratory pathophysiology, immune modulation and APRV.

In this episode, we right some wrongs. As we said in the beginning, given the fast pace we were bound to be wrong, and will be again.

1) New paradigm for COVID-19 patients

2) Procalcitonin: not as good as we thought

3) Malignant atelectasis and the crashing hypoxemia

4)SARS-COV-2 & DIC

5) Awake Proning / CPAP / Vent Splitting / Extubation

6) Ethical dilemmas

In this episode, we update you on:

Transmission

HFNC/CPAP

Steroids?

The fall of Kaletra

Come take a listen. Know that we are all in this together.

There is a lot of attention to this growing global health concern. Come listen for what will be a continuing update for all thing clinically pertaining to COVID-19.

Pathogenesis

Transmission/PPE

Respiratory support

ARDS management

Steroids?

Antivirals

In this episode, we cover a core component of any resuscitationists tool kit: vasoactive agents.

We've got your vasopressors, your inodilators, your inopressors, you oral cheat code and some hail merry approaches. Come listen for all things pressure and flow.

In this episode, we cover one of those cardinal causes of vasodilatory shock; anaphylaxis.

Come listen to solidify your clinical diagnosis, and domination of all things epinephrine.

In this episode we cover that rapidly progressive, big stakes entity that is Status epilepticus - the unrelenting seizure. Definition, Big Benzoes and where to go after that first line. Come listen for all things Keppra, Propofol and Ketamine.

In this episode we cover the last common electrolyte derangement you'll face in the ICU; hypocalcemia. From tetany to hypotension, we've got you covered for an approach to recognition and treatment.

In this episode we cover that rather bothersome component of your AGMA... toxic alcohols. Who is high risk, when and how to screen, and of course a tight approach to treatment. Don't forget... always call your local friendly toxicologist.

In this episode, we cover that daily discussion point... can this line, possibly, be infected? Come refresh yourself on diagnosis, microbiology and treatment.

In this hallmark episode (we just hit 500k in downloads!), we cover an approach to dominating the diuresis. We cover all the major points:

-Loop diuretics and how not to screw them up

-Using thiazides to maximize ongoing diuresis

-When to add spironolactone

-How not to always just cheat and start the CRRT machine

Welcome to 2020, everyone! In this fresh new podcast we cover all things severe hypothyroidism; AKA Myxedema Coma.

Diagnosis. Treatment. Whats the deal with T4 vs T3. Who gets the roids. Come listen to it all!

Happy Holidays everyone! In this episode we cover the general support of those patients that are working hard to breathe. Come listen about NIPPV (BiPAP and High Flow Nasal Cannula).

In this episode, we cover that rapidly progressive, easy to miss, relatively better survived leukemia: acute promyelocytic leukemia.

Come read about pathophysiology, and then listen to the summary that covers when to suspect clinical APL, the use of ATRA, and that scary hyperfibrinolysis (DIC but worse). Just to leave you with more, we cover Differentiation syndrome (aka retinoic acid syndrome).

In this episode, we cover all things ICU level hyponatremia. From a mild inconvenience to a refractory seizing patient, we've got you covered for diagnosis, treatment and risk stratification.

In this episode we cover that low serum potassium, aka Hypokalemia. From the minor repletion to the immediate resuscitation of a patient with VF arrest secondary to severe hypokalemia, we have you covered. So read the post, then come take a listen to review all things hypo K!

In this episode we cover the definition and concrete way how to identify and correctly diagnose brain death. This is something we need to get right, so grab a coffee and come take a listen.

In this episode we cover both accidental and non-accidental hypothermia. Come listen for a good review on:

1. Clinical Clues
2. Passive and Active re-warming
3. Modification of standard ACLS approach
4. Complications of hypothermia
5. and much much more...

PS: Many apologies to cardiac anesthesiologists and perfusionists: core after-drop is a thing, but we don't want to cloud the issue of priorities in rewarming.

In this episode, we cover the 2019 version of a TCA overdose: Bupropion. AKA: Wellbutrin / Illbutrin (Shoutout to Tox & The Hound).

Read the post then get an audio summary of the clinical diagnosis, risk stratification, Activated charcoal, whole-bowel irrigation and finally all things VA-ECMO for the extreme toxicities.

In this episode, we cover that sneaky presentation of acalculus cholecystitis. When that ALP/GGT start climbing, or your chronically critically ill patient gets septic again, you need to know about this!

In this episode, we cover that pesky Carbon monoxide. From minor exposure to critically ill, we have you covered for:

-Diagnosis

-Testing

-Hyperoxia

-Hyperbaric

-Bleeding Edge Therapies

Just when you thought your post MI patient has made it through the woods... they start to crump! In this episode we cover the Ddx and approach to post myocardial infarction complications. Come listen to review all the greatest hits.

-Rupturing things

-Pericarditis

-Access issues

-Arrythmias

In this episode we cover that rare but fun element to your cyanosed patient Ddx. When your hemoglobin gets oxidized to Fe3+, badness can ensure. Enjoy this quick refresher.

In this episode, we cover one check box on your bilateral airspace opacification differential diagnosis. Come take a listen for Diffuse alveolar hemorrhage and pulmonary vasculitis in the ICU.

-Imaging findings

-Bronch?

-What labs to order (you can't just write "vasculitis work up")

We know you all have been waiting for it! Here is one of the foundational chapters for the IBCC. All things asthma. We've got everything from physiology, to bleeding edge sedation approaches.

Come take a (longer) listen to solidify everything you read in the post:

-Presentation / patient phenotypes

-Initial management

-Escalation to salvage treatments

-Vent Management & ECMO

In this episode, we further explore the acid-base-palooza with Metabolic Alkalosis.

We give you 10 things to treat said event with, however, sometimes its best to let sleeping dragons lie. Josh even snuck in some acid infusion!

In this episode we have a quick little refresher on Non-Anion-Gap Metabolic Acidosis for you! Enjoy!!!

Continuing on with metabolic-palooza:

Here is the core approach to Anion-Gap Metabolic Acidosis. We've got the KULT, we've got the labs/treatment and everything in between.

In this episode, we cover the foundations to every day clinical medicine in the ICU: Acid base. As our patients are either often too sick to regulate their own homeostasis, or what we are doing to them prevents their lungs or kidneys from doing so, we give you the approach to recognizing Acid Base disorders.

Step 1: Calculate the Anion Gap

Step 2: Look at the Bicarbonate level

Step 3: Compare the change in Anion Gap to the Change in Bicarbonate

In this episode we explore the controversies in how to classify the hemodynamic effects of pulmonary embolisms.

We also cover:

-Risk Stratification

-Thrombolysis

-Anticoagulation

-Novel therapies

-The crashing & hypoxemic PE patient

In this episode, we cover all the big hits for anticoagulant management in your bleeding patients.

-Warfarin

-DOAC

-Anti platelets 

-Heparin and LMWH

-And More!

In this episode, we cover all things you need to know cold when your patient's cells are bursting all over the place. 

-Life threatening Hyperkalemia

- Purine Nucleotide Management

-Rasburicase

-Dialysis

In this episode, we take a break from controversial subjects and cover all thing magnesium related for critical care.

Come take a listen for diagnosis, identification, and treatment of low and high levels of magnesium.

Here it is, a total beast of a podcast. We cover one specific approach to patients in septic shock. We highlight all the must-know aspects:

-patient identification and risk stratification

-fluids

-vasopressors/inotropes

-The Metabolic Resuscitation Protocol

We even re-leak the CITRIS-ALI trial for you... its going to be an epic Doozy. So make sure you have a proper 60+min to really take it all in.

In this episode we cover the simultaneous approach of sorting out the airway from hell, and treating both the histamine and bradykinin induced angioedema. We even snuck some novel use of TXA into the post!

In this episode, we follow-up on the very "heated" debate that this post sparked on the interwebs. Come listen to all things ICU level-hyperthermia. We've got the ice baths. The cold fluids. The dry air. We cover it all!

In this episode we go over a general approach to your patient with Massive Hemoptysis. When lungs have blood in them = badness. We give you a targeted approach to stay cool, find the bleed, and stop it in the most efficient manner possible. Come listen for discussions around securing airway, protecting the good lung, CT first, and definitive management.

In this episode, we cover the last half of phenobarbital week! This is a long one, but we cover the Farkas manifesto on by phenobarb is superior to standard approaches to alcohol withdrawal management.

-Dosing

-Indications/Contraindication

-Adjuvant therapies & more

In this episode, we will cover all those pesky things that can make your patient sick from the RUQ: namely the biliary tract!

Ascending cholangitis, Cholecystitis and all the important pearly for imaging, antibiotics and source control options.

If your nursing colleagues can smell it, and you can't, fear not! We've got you covered for all things C. Diff on an ICU-level. Also, the audio quality is particularly bad on this episode, we apologize. Just the realities of recording on the road! 

In this episode, we cover the always vexing crystalloid vs colloid debate. Farkas also brings it to the next level with a new paradigm for using large volume resuscitations to treat your patient's acid-base disturbances. Come take a listen for all things alkalinizing, acidifying and maintaining.

In this episode, we've got you covered for all things hypercalcemia. Erase those memory banks that are filled with hyper-hydration and forced diuresis and come fill them back up with appropriate fluid resuscitation, the 1-2-punch for those osteoclasts and all the rest of the pearls for hypercalcemia.

Pull those ankle socks up, and get ready for some ankle-clonus-good-times. In this episode, we cover one of those "hot and bothered" presentations of Serotonin Toxicity. Come listen to a summary of the chapter that includes, definition, clinical presentation, treatment and clinical pearls.

In this episode, we cover an often overlooked infectious cause of that ICU level patient presenting with all kinds of badness: come listen for a sound education on all things babesiosis, anaplasmosis & ehrlichiosis, and rocky mountain spotted fever (RMSF).

Either its a glaringly obvious diagnosis (because your patient is bright yellow and wont wake up) or its apart of a complex presentation, hepatic encephalopathy is one presentation you need to have down!

Come listen to consolidate your knowledge around nitrogen reduction, shunts (the good, the bad, the ugly) and all things HE!

In this episode, we help you take a more nuanced approach to those patients with "coca-cola urine." When that CK is a climbing and you don't know what to do, remember these pearls!

In this episode, you get a two-for-one. Come for the hypophosphatemia, stay for the hyperphosphatemia.

Contrast induced nephropathy is the "white walker" of critical care and emergency medicine. Come take a listen as we discuss the potential error in creating a clinically non-meaningful entity, and how we should address this in our daily clinical work.

In this episode we cover all those big highlights for infective endocarditis. Come solidify your approach to clinical presentation of both left and right sided disease, approach to imaging, and empiric therapy. We've even got the hot topic of dual coverage down!

In this episode we cover the finer points of the high stakes resuscitation of VF / VT "Storm."

Come get a solid approach to identification, resuscitation and nuanced management.

Have you ever seen that patient with a bicarb of 6 and a lactate of 14, and they are just smiling at you and texting their spouse about taxes? In this episode, we explore the direct, indirect, and obscured role that metformin can play in your critical care patients. Come listen for all things diagnosis, classification and some special discussion around GIK, Methylene Blue and when to spin that dialysis machine.

This often mis-understood "penicillin allergy" can have far more dire impacts on the population you would think. Come take a listen and explore the pathophysiology of R1-side chain impact on true allergy, what to do about it, and how it impacts antimicrobial selection and use.

In this episode, we've got you covered for this hypertensive emergency that you need to know cold. Come take a listen for all things around diagnosis, risk factors, clinical presentation, labs and treatment. We've got your magnesium. We've got your labetolol. We even have a few new tricks for hemolysis.

Just like when you were a kid and that science fair volcano was spewing badness everywhere... an unchecked perfusion pressure can wreak havoc on your end organs. In this podcast, we cover the true primary emergency that results from too high of perfusion pressure. Come take a listen for all things diagnosis, treatment and even a nice coverage of PRES.

In this episode, we cover the often missed "abdominal compartment syndrome." Lace up those shoes, get ready for your commute, and let us review for you the diagnosis and treatment of this critical care quagmire.

In this episode we explore this rare but commonly seen entity of NMJ caused weakness. Come listen to review the patient population, identification and management of MG CRISIS.

In this episode, we start off with all those familiar aspects of APAP toxicity that you've heard about. Then we kick it up a notch and give you new pearls around Massive ingestions and high dose NAC infusions, when to Dialyze (you read that correctly) and even more great pearls! Come take a listen.

In this episode we will cover all the highlights you need to know about hypernatremia. Serum sodium... we see you yawning already! But if you want to level up your critical care skills, you need to pay attention to this often missed cause of serious morbidity in our ICUs.

Toxicology is fun. Salicylate overdoses can be intimidating, so come take a listen to get you ready for the next patient you see, so you can keep them out of that death-spiral!

In this episode, we cover the diagnosis of this must-not-miss-unicorn. Come take a listen for a lengthy discussion around management, including the controversial use of beta-blockade.

In this episode, we've got a great approach to low platelets in the ICU patient population. Come take a listen for approach, management, what not to miss, and all things HITT.

Here it is... it took a mythical amount of time to prepare, so we hope you enjoy this long format cast on the broad topic of antibiotics. We cover the highlights of all the usual suspects, beta-lactams, cephalosporins, aminoglycosides, macrolides and all the weird and wonderful.

Make sure you read the post before diving into this beast!

Every resuscitationist MUST have this basic approach down cold. Come take a listen to the foundation of our specialties in what the French like to say "Reanimation."

Approach and treatment for all those SICK looking patients.

ICU level Influenza. Very pertinent for this time of year. Come take a listen and explore clinical management pearls, and some bleeding edge discussion for adjuvant therapy on your hardcore viral patients.