16 Minutes News by a16z

By Andreessen Horowitz

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Description

Introducing our new podcast, 16 Minutes, a short news podcast where we cover the top headlines of the week, the a16z podcast way -- why are these topics in the news; what's real, what's hype from our vantage point; and what are our experts' quick takes on these trends? About the a16z Podcast: Discusses tech and culture trends, news, and the future -- especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This podcast is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes -- and now shows -- are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!

Episode Date
Drugs & Debates: Real World Data, Randomized Controlled Trials
00:17:22

If the best way to know whether a medicine is effective is through a clinical trial, then where does (and doesn't) real-world data and real-world evidence come in? The topic is always top of mind in drug development, with additional focus as of 2016 thanks to the 21st Century Cures Act -- but is especially heated lately given recent concerns and claims around particular drugs in the context of the novel coronavirus pandemic.

So in this short-but-deep dive episode of 16 Minutes on the News, a16z general partner in bio Vijay Pande -- previously a professor of Chemistry, Structural Biology, and Computer Science at Stanford University (as well as founder of Folding@Home) -- breaks down the debate between RWE vs. RCT (real world evidence and randomized controlled trials), in conversation with Sonal Chokshi. Is it a tradeoff between speed of innovation and safety, or is it a false dichotomy altogether? Where do and don't statistics come in when it comes to policy? How has, and could, the role of the FDA (as well as payers reimbursing healthcare) evolve here? And where can technology help?

Mar 29, 2020
The Economic Virus - Monetary Policy, Fiscal Policy, and Small Business
00:18:03

The U.S. Federal Reserve recently made a range of moves -- from cutting interest rates to near zero (which it also did in the 2008 financial crisis) and using other tools -- to support "the flow of credit to households and businesses, thereby promote its maximum employment and price stability goals" during this current pandemic and public health crisis.

However... what does this mean for small businesses, which may be most impacted? What's the difference between monetary and fiscal policy here; where does rhetoric (such as around buybacks vs. dividends) confuse; how does adjudication and disbursement work... and where could technology come in?

In this short-but-deep dive episode of 16 Minutes on the News, a16z general partner on fintech Alex Rampell -- who also covered quantitative easing and more on a previous episode -- breaks it all down in 18 minutes, with useful analogies, in conversation with Sonal Chokshi.  How do we stop not just the novel coronavirus, but the economic virus, too?

 

image: Edna Winti / Flickr

Mar 22, 2020
Hospitals' Historic Moment & the New Data Rules
00:19:18

This episode of 16 Minutes on the News covers the U.S. Department of Health and Human Services' "historic rules" to provide patients more control of their data. They've been a long time coming, and despite recent fights over them, the final rules are now finally here as of this week.

So in this short but deep dive, a16z bio experts -- general partner Julie Yoo and Venkat Mocherla in market development (in conversation with Sonal Chokshi) -- go into:

  • 0:47 how the rules fit into our healthcare system, especially with everything else going on right now in hospitals and beyond;
  • 3:11-8:37 what the rules specifically are and why they matter;
  • 6:21 concrete examples including why things like notifications are important;
  • 8:42 implications for providers and payers, including examples such as prior authorization;
  • 11:10 where privacy concerns do and don't come in, given how much information is contained in records;
  • 13:40 implications for startups, tech incumbents, and traditional players in healthcare, and new types of data down the road; and
  • 18:27 the bottomline.
Mar 14, 2020
Gaming & Chrome OS/Steam; Going Cashless; Coronavirus Latest
00:19:47

This episode of 16 Minutes on the news covers:

  • Google could bring Steam support to Chrome OS, according to an earlier unconfirmed report, and what that could mean for the broader gaming ecosystem, developers as well as devices -- with a16z general partner Andrew Chen and Jonathan Lai on the consumer team;
  • New York restaurants and retail establishments can no longer reject cash payments under legislation that was passed by the City Council there; what this says about the banking system more broadly, why it's a regressive tax on the poor and therefore a progressive move -- at 8:57 with a16z general partner Alex Rampell on the fintech team;
  • updates on COVID-19 disease -- at 16:44 based on latest reports from WHO and CDC as of Friday March 6.

...with Sonal Chokshi.

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The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.

This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.

Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

Mar 08, 2020
What's Up With All These Fintech Acquisitions; SEC Rules
00:15:27

This episode of 16 Minutes on the news covers:

  • all the recent fintech acquisitions! from Intuit announcing it's acquiring Credit Karma this week to Morgan Stanley announcing it's acquiring E-trade last week to Visa acquiring Plaid last month, and so on -- what’s going on, why, and why now? -- with a16z general partner Anish Acharya;
  • recent hearing on SEC's complaint against Telegram, which turns out not to be about cryptocurrency at large, a particular subset of cryptocurrencies, or whether a cryptocurrencly is inherently a security -- but may have broader implications for policy and policy making -- at 7:57 with a16z managing partner Scott Kupor;

...in conversation with Sonal Chokshi.

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The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.

This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.

Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

 

Feb 28, 2020
Coronavirus Updates
00:20:22

This episode covers the latest updates since our previous deep-dive on the novel coronavirus outbreak. We cover the latest developments -- new name, new declarations, new numbers, new definitions -- as well as:

  1. practical implications for the U.S. healthcare system given how it works today, and where we might go in the future -- with a16z general partner Julie Yoo, given our vantage point in tech; and
  2. how the rt-PCR test works, and other updates about what the data do and don't tell us, and whether and what terms are useful or not -- with a16z bio partner Judy Savitskaya;

...in conversation with Sonal Chokshi.

Sources for this episode and/or other background links:

image: 2019 Novel Coronavirus (2019-nCoV), CDC, via Wikimedia Commons

Feb 19, 2020
Epic Battles in Healthcare, FICO Changes
00:21:03

This episode of 16 Minutes on the news covers:

  • FICO credit score changes, what are they, do they matter? -- with a16z fintech general partners Angela Strange and Anish Acharya;
  • electronic health record provider Epic's letter urging hospitals to oppose government regulations that would make it easier for patients and companies to access medical information, and where is the Plaid of healthcare? -- at 10:19 with a16z bio general partner Julie Yoo;

...in conversation with Sonal Chokshi.

Background links / pieces mentioned in this episode:

 

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The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.

This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.

Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

Feb 07, 2020
Coronavirus Outbreak
00:19:49

This episode of 16 Minutes on the news from a16z is all about the recent coronavirus outbreak -- or rather, a new type of coronavirus called 2019-nCoV for 2019 novel coronavirus. Since it's an ongoing and fast-developing news cycle, we take a quick snapshot for where we are, what we know, and what we don't know, and discuss the vantage point of where tech comes in. Topics covered include:

  • definition of a virus, categories of coronaviruses
  • origins and spread
  • how this stacks up so far against SARS and MERS
  • speed of sequencing, implications of genomic info
  • speed of information sharing
  • R0 ("r-naught"/"nought") and what it measures
  • different ways to think about how bad a given epidemic is
  • current moves and treatments

Our a16z guest is Judy Savitskaya on the bio team, in conversation with Sonal Chokshi.

Link sources or background readings for this episode:

Other background readings / pieces mentioned in this episode: 

  • "Scientists are moving at record speed to create new coronavirus vaccines--but they may come too late", Jon Cohen, Science (AAAS), January 27
  • "Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China", The Lancet, January 24
  • "Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin", bioRxiv, January 2 *note - preprint, NOT peer reviewed*
  • "The deceptively simple number sparking coronavirus fears", Ed Yong, The Atlantic, January 28 *this appeared AFTER this episode was recorded, so sharing here as additional reading only*
Jan 30, 2020
CES 2020 - Screens, 8K, 5G, Cars, Micromobility, Smart Home
00:17:47

This episode of our news show teases apart what was just a concept, what's near from the annual Consumer Electronics Show (CES 2020). Board partner Steven Sinofsky (in conversation with Sonal Chokshi) takes us on a quick tour of the based on his annual field trip report from the floor.

Topics covered include:

  • folding screens and 8K displays
  • 5G, wi-fi 6, new millimeter wave 5G
  • transportation: cars, voice, micromobility
  • smart home automation and security
  • batteries and USB-C

Articles/ headlines in this episode:

Jan 18, 2020
Regulating AI; Negative Interest Rates (#19)
00:21:20

In this 19th episode of our news show, where we cover recent headlines from our vantage point in tech, we cover the following news items (in conversation with Sonal Chokshi):

  • recent moves to regulate artificial intelligence (AI) software including the White House's recent guidance (and op-ed from the U.S. CTO) on AI in general, as well as limits to exports of specific AI software that went into effect this week -- with operating partner Frank Chen (whose talk was cited in an earlier White House report);
  • recent activity on the topic of negative interest rates as well as quantitative easing, given recent remarks (and paper) from former chairman of the Federal Reserve Ben Bernanke -- with general partner Alex Rampell, who covers all things fintech.
Jan 13, 2020
Personal Genomics - Hype vs Reality (#18)
00:20:08

For our first episode of 2020 -- #18 of our show 16 Minutes, where we cover recent headlines, the a16z way, from our vantage point in tech, and especially what's hype/ what's real -- we do one of our special deep-dive episodes on a single topic: personal genomics.

It’s a turn of the decade — and January-appropriate! — look backward/ look forward given recent and past retrospective and prospective pieces in the media on the promise, and perils, of the ability to sequence one’s DNA and what it means for personalized medicine, criminal investigations, privacy, and so on.

Our a16z expert for this episode is general partner Jorge Conde, who has a long history in the space, in conversation with host Sonal Chokshi. They cover everything from where genealogy databases and large datasets come in to fetal testing, multi-omics, and much more spanning past, present, and future.

Jan 06, 2020
Star Wars in Fortnite; Encryption Ultimatum (#17)
00:23:26

On this show, we cover recent headlines, the a16z Podcast way -- what’s hype, what’s real; why they matter from our vantage point in tech -- and this week, we cover the following news (in conversation with Sonal Chokshi):

  1. Star War trailer premieres in... Fortnite? What's the significance of the latest Star Wars trailer debuting inside a video game over a movie theater or TV or even YouTube and Facebook? It has to do with the bigger picture of games, social networks, and virtual worlds; so what are the implications for marketers, game developers, and how we will live/work/play? -- with Jonathan Lai, consumer team
  2. Congress warns tech companies to take action on encryption... or else! Concerned about protecting the most vulnerable Americans and devices "going dark" to law enforcement (especially given "several serious cases where we can't access the device in the time period where it is most important for us to access it"), Congress recently sent a warning to tech companies to get their "act together" on encryption... or else "we will impose our will on you", by this time next year. But what if we're having the wrong conversation to break the deadlock, and what conversation could we be having? -- with Martin Casado, general partner, and operating partner for security Joel de la Garza

Relevant/ related links:

Dec 21, 2019
Direct Listings NYSE SEC; Vaping Apps & Apple, CBD & FDA (#16)
00:15:47

This is the 16th episode of 16 Minutes, our news show where we cover the top headlines, the a16z Podcast way: what’s real / what’s hype; why they matter from our vantage point in tech.

This week, we cover the following news (in conversation with Sonal Chokshi):

  1. NYSE & SEC back and forth over direct listings -- The NYSE recently proposed allowing companies to raise capital during direct listings (currently, they're different than IPOs in that there is no offering); the SEC rejected it; and they just filed a new proposal... but beyond this news and these artifacts, what's the bigger picture when it comes to other structural factors involved here? -- with Scott Kupor.
  2. vaping apps & Apple; FDA & CBD-- two recent moves: Apple banning 181 vaping apps from its app store, FDA issuing warning letters against 15 companies with products that have CBD in them; what's our quick take on the blurring lines between these two seemingly different bits of news? -- with Vijay Pande.

Relevant/ related links:

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The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.

This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.

Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

Dec 16, 2019
Alternative Data for Credit; Retail Shopping Shifts (#15)
00:19:11

This is the 15th episode of 16 Minutes, our news show where we cover the top headlines, the a16z Podcast way: what’s real / what’s hype; what's interesting from our vantage point in tech. This week (after a brief hiatus for our annual innovation event and November holidays), we cover the following news... in conversation with Sonal Chokshi:

  1. use of alternative data in credit underwriting -- Five federal regulatory agencies (the Federal Reserve Board, the Consumer Financial Protection Bureau, the Federal Deposit Insurance Corporation, the Office of the Controller of the Currency, and the National Credit Union Administration) recently issued a joint statement on the use of alternative data in credit underwriting; what does this news really indicate, and what are the implications for both consumers and companies? -- with Seema Amble and Rex Salisbury;
  2. big annual shopping days and retail trends -- From Black Friday to Cyber Monday to Singles' Day and Prime Day and seemingly unprecedented sales, where are we in the shift from offline to online commerce, on the so-called "death of retail", and on other tech (chatbots, logistics) changing shopping? -- with Jeff Jordan and Connie Chan.

Relevant/ related links:

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The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.

This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.

Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

Dec 16, 2019
Pharma Drones; Veteran Health Records; Light to Voice Hacks (#14)
00:19:55

This is the 14th episode of 16 Minutes, our weekly-ish news show where we quickly cover the top headlines of the week, the a16z Podcast way: what’s real, what’s hype from our vantage point in tech. This week, we cover the following news -- with a16z experts general partner Julie Yoo and market dev partner Venkat Mocherla from the bio team, and former CSO/ a16z security operating partner Joel de la Garza -- in conversation with Sonal Chokshi:

  1. UPS drones deliver prescriptions -- For the first time ever, drones delivered prescription medication directly to residential homes and retirement homes in North Carolina this month; but why don't we already get drugs by delivery? And what's the significance of pharma as a node in the healthcare system?
  2. Apple opens health records to vets -- Apple and the Department of Veterans Affairs announced recently that veterans can now access their health information on their iPhones; why is (or isn't) this significant, and wherefore the promise of EHRs (electronic health records)?!
  3. hackers can use lasers to command voice devices -- Security researchers were able to send laser-powered “light commands” to smart assistants (including products like Amazon’s Alexa, Apple’s Siri, Facebook’s Portal, and Google Assistant) to take full control over them at specific distances; how worried should we be, and how does this affect the future of a voice-enabled world?

Relevant/ related links:

Nov 15, 2019
Ok Boomer; Microtransaction Fraud in Games (#13)
00:17:28

This is the 13th episode of 16 Minutes, our weekly-ish news show where we quickly cover the top headlines of the week, the a16z Podcast way: what’s real, what’s hype from our vantage point in tech. This week, we cover the following news -- with a16z experts general partner Connie Chan and D'arcy Coolican from the consumer team, and former CSO/ a16z security operating partner Joel de la Garza -- in conversation with Sonal Chokshi:

  1. OK Boomer meme and meaning -- What makes this meme news, given current and coming tech trends around meme-to-merchandise, ecommerce, video, app design, the future of social... and the overall zeitgeist between generations and cultural transitions?
  2. fraud in gaming microtransactions/ trading -- Is money laundering really happening through gaming microtransactions? What to make of Valve's recent restriction that Counter-Strike: Global Offensive container keys cannot be traded or sold on the Steam marketplace because they are now "believed to be fraud-sourced" by worldwide fraud networks?

Relevant/ related links:

credits: @linzrinzz on TikTok

Nov 04, 2019
Crypto Regulations; ATM Fees (#12)
00:20:09

This is the 11th episode of 16 Minutes, our weekly news show where we quickly cover the top headlines of the week, the a16z Podcast way: what’s real, what’s hype from our vantage point in tech. This week, we cover the following news -- with a16z experts managing partner Scott Kupor and general partner in fintech Angela Strange, respectively, in conversation with Sonal Chokshi:

  1. crypto & regulation/policy updates from the SEC and IRS -- including the SEC releasing an announcement that it settled charges for an unregistered ICO, and the IRS' issuing guidance (in the form of a revenue ruling and answers to FAQs) on tax treatment for hard forks and air drops;
  2. ATM fees at record highs -- where it was reported that it now costs ~$4.72 (vs. $1.97 in 1998, as tracked by Bankrate.com) to withdraw money from ATMs not owned by one's bank, which disproportionately falls on low-income people in neighborhoods banks tend to avoid

For relevant background/ related links:

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The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.

This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.

Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

Oct 20, 2019
CRISPR! Policy, Platform, Trials (#11)
00:23:46

This is the 11th episode of 16 Minutes, a weekly show where we quickly cover the top headlines of the week, the a16z Podcast way: why are these topics in the news; what’s real, what’s hype -- from our vantage point in tech.

This week, we do a 20-ish minute deep-dive on CRISPR, to tease apart the FUD from the facts given a bunch of recent news (not research!) around the gene-editing platform. The news implications range from policy to practice:

  • At the end of July, one of the first laws to directly regulate CRISPR was signed in the state of California by Governor Gavin Newsom, making it illegal for "gene therapy" kits to be sold, unless they have a clear warning label that the kit is "not for self-administration” -- this policy may affect future "biohacking"... but also, such kits don't really exist yet!
  • At the end of August, the Alliance for Regenerative Medicine (ARM, an TKTK) released a Therapeutic Developers’ Statement of Principles for the use of gene editing in therapeutic applications -- endorsed by 13 of the most active companies in the field -- while it supports somatic cell editing, it also asserts that germline gene editing "is currently inappropriate in human clinical settings".
  • The above news is also relevant given news of/ the scandal from earlier this year (first revealed by MIT Technology Review) around "CRISPR babies" with germline edits born in China;
  • Meanwhile, clinical trials for CRISPR are coming of age, with the first publicly identified CRISPR patient (treating sickle cell disease) and the first CRISPR study inside the body (for LCA, the most common cause of inherited childhood blindness); how do these show pacing and containment of risks (somatic cell, monogenetic phenotypes, ex vivo, etc.)?

Finally, how does all this news affect innovation in gene therapies and other applications? When it comes to engineering the genome -- including tech challenges and startup opportunities -- what might we  borrow from the history of innovation here? If CRISPR is not a single tool or set of proteins but a platform, what becomes possible? General partner Jorge Conde and partner Andy Tran, both of the a16z bio team, share their thoughts on all this and more with host Sonal Chokshi in this episode of 16 Minutes.

Oct 08, 2019
Amazon Healthcare, Oculus & VR/AR, Google Quantum Supremacy? (#10)
00:22:32

Our news podcast, 16 Minutes -- where we quickly cover the top headlines of the week, the a16z way (why are these topics in the news; what's real, what's hype from our vantage point of tech trends) -- is now only available as its own show feed, separately from the main a16z Podcast... so be sure to subscribe wherever you get your podcasts if you want our weekly news & tech take!

This is the tenth episode of the show, and this week we cover a variety of topics with the following a16z experts:

  • Amazon Care healthcare news this week that they're now providing a virtual medical clinic for employees, initially in Seattle, using telemedicine and in-home visits; what does their delivering healthcare actually mean for both incumbents and startups... and the future of medicine? -- with Julie Yoo and Jorge Conde
  • Oculus Connect 6, Facebook's annual developer event, where there were a number of announcements about devices, content, and more that could be key to the evolution of virtual reality (VR) and augmented reality (AR) -- with Chris Dixon
  • Google quantum supremacy claim, as shared in a paper with/via NASA; what's fact, what's fiction about it; what does it actually mean (or not mean) for cryptography and other applications; and where are we, really, in quantum computing? -- with Vijay Pande

...hosted by Sonal Chokshi.

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The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.

This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.

Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

Sep 30, 2019
All the Recent Phone Hacks (#9)
00:19:51

This is episode #9 of our news show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they’re in the news; why they matter from our vantage point in tech -- and share our experts’ views on the trends involved.

This week we do a short but deep dive to tease apart the FUD from the facts on all the phone hacks of late (also, arguably, one of the worst years on record for certain device manufacturers) -- given the following news:

  • Just this week, the FBI’s Cyber Division released a notification to private industry on “Cyber Criminals Use Social Engineering and Technical Attacks to Circumvent Multi-Factor Authentication”;
  • Last week, a telecom security firm reported a vulnerability called “Simjacker” where SMS containing spyware-like code "takes over" a phone's SIM card in order to retrieve and perform sensitive commands, regardless of platform or device;
  • Over the past month, Google and Apple have been going back and forth over a post the former released, “A very deep dive into iOS Exploit chains found in the wild”, where a small collection of hacked websites were using iPhone zero-day vulnerabilities to target China's Uyghur Muslim community (though Google is not the one who revealed the specific websites, Apple did confirm it in their response a week later) -- what do we make of this exchange; of the fact that zero-day hacks are now more expensive on Android than on Apple; and of Apple's ethos when it comes to a third-party ecosystem for security?

Finally, how should we think about phone authentication overall when it comes to security, and what can we do to secure ourselves? Our a16z experts -- general partner Martin Casado and former chief security officer/ operating partner for security Joel de la Garza -- share their thoughts on all this and more with host Sonal Chokshi, in this episode of 16 Minutes.

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The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.

This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at a16z.com/investments.

Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see a16z.com/disclosures for additional important information.

Sep 23, 2019
Apple Camera, Services; Wearables - Where are We (#8)
00:19:59

This is episode #8 of our news show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- and share our experts' views on these trends.

This week we cover, with the following a16z experts:

...hosted by Sonal Chokshi.

 

The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.

This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.

Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

Sep 16, 2019
Apple Card, BEC Scams Federal Indictment (#7)
00:17:54

This is episode #7 of our news show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- and share our experts' views on these trends.

This week we cover, with the following a16z experts:

...hosted by Sonal Chokshi.

The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.

*This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.

Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

Aug 25, 2019
Health Claims Data, Corporate Breaches (#6)
00:17:13

This is episode #6 of our new show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- and share our experts' views on these trends as well.

This week we cover, with the following a16z experts:

  • health claims, insurance & big tech, and healthcare data liquidity -- with a16z bio partner Julie Yoo;
  • Capital One data breach, cloud security, and corporate hacks -- with a16z operating partner for security Joel de la Garza;

...hosted by Sonal Chokshi.

Aug 12, 2019
Fed Real-time Payments, Death of Retail (#5)
00:16:45

with @astrange @jeff_jordan and @smc90

This is episode #5 of our new show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- and share our experts' views on these trends as well.

This week we cover, with the following a16z experts:

  • Federal Reserve real-time payment and settlement service FedNow, the U.S. payments rail, and fintech -- with a16z general partner Angela Strange;
  • Barney's bankruptcy, the "death of retail", and ecommerce -- with a16z general partner Jeff Jordan;

...hosted by Sonal Chokshi.

Aug 12, 2019
The Opioid Crisis (#4)
00:18:19

This is episode #4 of our new show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- and share our experts' views on these trends as well.

This week we do a short but deep dive on the opioid crisis, given recent data around where and who was behind the manufacturing and distribution of specific opioids:

  • How do opioids work, why these drugs?
  • Who's to blame?
  • What are other directions for managing pain -- and where could tech come in, even with the broader social, cultural, and structural context involved?

Our a16z experts in this episode are a16z bio general partners Jorge Conde and Vijay Pande, in conversation with host Sonal Chokshi.

Aug 04, 2019
Fortnite, Esports, Gaming, and Entertainment (#3)
00:18:14

This is episode #3 of our new show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- and share our experts' views on these trends as well.

This week we do a short but deep dive on esports, given recent news of the inaugural Fortnite World Cup champion, and how this all fits into the broader trends in gaming, social networks, and the future of entertainment.

Our a16z experts in this episode are general partner Andrew Chen and investing team partner D'Arcy Coolican, both of the consumer vertical, in conversation with host Sonal Chokshi.

Aug 04, 2019
Mobile Malware, Drug Pricing (#2)
00:19:36

This is episode #2 of our new show, 16 Minutes, where we quickly cover recent headlines of the week, the a16z way -- why they're in the news; why they matter from our vantage point in tech -- and share our experts' views on these trends as well.

This week we cover, with the following a16z experts:

  • mobile malware and a recent report of a new kind in the wild and security in a post-perimeter world -- with a16z general partner Martin Casado;
  • drug pricing given recent proposals on the table, sharing a lay of the land for why drug pricing is so damn hard, what is a medicine, and where tech comes in -- with a16z bio general partner Jorge Conde and market dev partner Jay Rughani;

...hosted by Sonal Chokshi.


*The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.

 This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.

Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

Jul 28, 2019
Neuralink & Brain Interfaces, TikTok, FaceApp, iHeartRadio (#1)
00:20:10

Introducing our new podcast, 16 Minutes, a short news podcast where we cover the top headlines of the week, the a16z podcast way — why are these topics in the news; what’s real, what’s hype from our vantage point; and what are our experts’ quick takes on these trends?

This is the first episode of the show, and this week we cover the below topics with the following experts:

  • Neuralink’s recent news/ event/ whitepaper and the trend of brain-computer interfaces -- with a16z bio general partner Vijay Pande
  • TikTok video influencers and AI-driven media and commerce -- with general partner, consumer, Connie Chan
  • FaceApp and privacy beyond national security -- with operating partner, security, Joel de la Garza
    iHeart Radio and direct listings -- with operating partner, corporate development, Jamie McGurk

…hosted by Sonal Chokshi.


The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.

This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/.

Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

Jul 21, 2019