This Week in Virology

By Vincent Racaniello

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Subscribers: 983
Reviews: 5

Rachael
 Nov 28, 2020
excellent thanks for doing a great job


 May 29, 2020

excellent
 Apr 23, 2020
great information

Reed
 Jan 15, 2020
amazing in depth podcast on the nuts and bolts of all kinds of viruses. expect in depth discussions of papers by experienced scientists with a decent sense of humour. I can follow along most details even though I have not studied virology.


 May 31, 2019

Description

This Week in Virology is a netcast about viruses - the kind that make you sick.

Episode Date
TWiV 708: Alpaca llama full of nanobodies
02:01:11

The TWiVy team deconstructs CoronaVac, the inactivated SARS-CoV-2 vaccine produced by Sinovac Biotech, and production of multivalent camelid nanobodies that block infection with the virus and suppress selection of neturalization-resistant variants.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

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Weekly Picks

Dickson Photos of mob attacking Capitol
Brianne Video of Neutrophil Phagocytosis
AlanFishing Through the Apocalypse
Rich A Word on Statistics by Wislawa Szymborska
Vincent Letters from an American

Listener Pick

Mike – Have the new jab

Intro music is by Ronald Jenkees

Jan 17, 2021
TWiV 707: COVID-19 clinical update #45 with Dr. Daniel Griffin
39:38

In COVID-19 clinical update #45, Daniel Griffin discusses J&J Ad26 vaccine results, reactogenicity after the second dose of mRNA vaccines, expansion of vaccine eligibility, and the finding that encephalitis after SARS-CoV-2 infection is a cytokine release syndrome.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Jan 16, 2021
TWiV 706: Do as Dr. Fauci says
01:36:14

TWiV answers listener questions about pandemic response, excess deaths in 25-44 year olds, vaccines, vaccines, and vaccines.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

Brianne We Know Almost Nothing About Giant Viruses
Rich The Coccolithophores Project
Kathy v-safe and  Vaccine Handbook
Vincent – Gorillas at San Diego Zoo infected with SARS-CoV-2 (pdf)

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Jan 14, 2021
TWiV 705: Rocky Mountain COVID with Emily Travanty
01:50:55

Emily Travanty from the Colorado Department of Public Health and Environment joins TWiV to discuss how her laboratory was the first in the US to detect the SARS-CoV-2 variant VOC 202012/01.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Emily Travanty

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Weekly Picks

DicksonRandal Despommier on saxophone
BrianneGiant Microbes SARS-CoV2
AlanWest of Loathing
Rich Draft landscape of COVID-19 candidate vaccines
VincentSARS-CoV-2 spillover events

Listener Pick

Daniel – His Vaccine Story Inspired His Father To Write A Disney Classic

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Jan 10, 2021
TWiV 704: COVID-19 clinical update #44 with Dr. Daniel Griffin
32:03

In this COVID-19 clinical update, Daniel Griffin summarizes current status of vaccination in the US, discusses a study on convalescent sera from Argentina, use of remdesivir in patients with kidney disease, and provides further considerations on the use of Ct values in patient management.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Jan 09, 2021
TWiV 703: Does dose matter?
02:04:55

On this episode, a discussion of why modifying the dose schedule of the mRNA vaccines in the US is not a good idea, evidence that lower Ct values on hospital admission is associated with higher mortality, and dose-dependent response to SARS-CoV-2 infection of ferrets.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

BrianneLinsey Marr on masks
KathyStriped Martian Sand Dunes and
RichHow Microwaving Grapes Makes Plasma
Vincent Musings of an anonymous, pissed off virologist

Listener Pick

LauraAuld Lang Syne follow-up

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Jan 07, 2021
TWiV 702: Year of the Pandemic
01:37:10

For this first episode of 2021, the complete TWiV team reviews compelling virology stories of 2020, and thanks the multitude of guests who have helped us to navigate the pandemic, and our many listeners who turn to us for scientific facts.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

Dickson Best of 2020 by NASA and The Plague Year
Brianne Where Year Two of the Pandemic Will Take Us
Alan – Japan’s distinct form of vaccine hesitancy
Kathy Paul Offit updates on the vaccine rollout and Choral Scholars of University College Dublin (John Greene’s videoessay on the song)
Rich Do You Love Me?
Vincent Story on Katalin Kariko’s career

Listener Pick

LouiseVirus socks

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Jan 03, 2021
TWiV 701: COVID-19 clinical update #43 with Dr. Daniel Griffin
38:57

In Daniel Griffin’s final clinical report for 2020, he summarizes what we have learned about the clinical management of COVID-19 patients in the past year.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Jan 02, 2021
TWiV 700: 'Twas COVID and the aerosols
02:08:37

TWiV reviews additional data on the UK variant of SARS-CoV-2, the distinct variant spreading in South Africa, association of afucosylated antiviral IgG with severe COVID-19, approval of AstraZeneca vaccine in the UK, and winners of the pandemic poem contest.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

BrianneReady Player Two
Kathy Bert Hubert’s Reverse Engineering of the Pfizer/BioNTech vaccine
RichBoston Dynamics running robots
VincentFever by John Fuller

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Dec 31, 2020
TWiV 699: Arboviruses at ASTMH
01:27:11

From the 2020 online meeting of the American Society for Tropical Medicine and Hygiene, Vincent speaks with Jonathan Auguste, Carol Blair, Desiree LaBeaud, Louis Lambrechts, and Mauricio Nogueira about their careers and their research on arthropod-borne viruses.

Host: Vincent Racaniello

Guests: Jonathan Auguste, Carol Blair, Desiree LaBeaud, Louis Lambrechts, and Mauricio Nogueira

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Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Dec 27, 2020
TWiV 698: COVID-19 clinical update #42 with Dr. Daniel Griffin
40:09

Daniel Griffin provides his weekly clinical report on COVID-19, including his own experience with vaccination, guidelines for vaccine distribution, reasons for under-utilization of monoclonal antibody therapy, and much more.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Dec 26, 2020
TWiV 697: The sky is NOT falling
02:15:56

TWiV reviews the latest data on the UK variant of SARS-CoV-2, including some properties of the variant and why it is being closely studied, development of liver cancer in a participant in a adenovirus-associated virus gene therapy trial, and answers to listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

Brianne EM Rap Podcast COVID update
KathyConjunction of Jupiter and Saturn and Tony Fauci vaccinated Santa Claus
RichChicken LIttle (wiki)
Vincentvirological.org

Listener Pick

GregSomeone who wants to make a difference
UliXKCD on statistics

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Dec 24, 2020
TWiV 696: Tear down that SARS-CoV-2 manuscript
02:11:13

TWiV explains that COVID-19 is not harmless for young adults, FAA approval for Pfizer mRNA vaccine, lack of justification for the claim of reverse transcription of SARS-CoV-2 RNA and integration into the human genome, and lack of evidence for increased transmission by new variants in the UK.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

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Weekly Science Picks

Dickson 2020 Audubon Photography Winners
Brianne COVID-19 Changed Science Forever
AlanEntangled Life by Merlin Sheldrake
Rich Lie of the Year: Coronavirus downplay and denial; John 18:38
Vincent How New York City Vaccinated 6 Million People in Less Than a Month (my article from 2009)

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Dec 20, 2020
TWiV 695: COVID-19 clinical update #41 with Dr. Daniel Griffin
41:33

Daniel Griffin provides his weekly clinical report on COVID-19, including thoughts on the first immunizations with Pfizer mRNA vaccine, the anticipated EUA for the Moderna vaccine, whether the vaccine prevents infection, not just disease, monoclonal antibody therapy, and much more.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Dec 18, 2020
TWiV 694: Mitigating COVID-19
01:50:33

On this episode, TWiV makes Bloomberg Business News 2020 Jealousy List, crushing of CDC revealed by insiders, seasonal influenza during the COVID-19 pandemic, FDA briefing documents from Moderna, and three-quarters attack rate of SARS-CoV-2 during an unmitigated epidemic in Brazil.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

Brianne Fears of a ‘Twindemic’ Recede as Flu Lies Low
Kathy Faculty Equity & COVID-19 UM ADVANCE
Rich ‘Sistine Chapel of the ancients’ rock art
Vincent Winners of ASM Agar Art Contest 2020

Listener Pick

Johnye2020 Year of the Vax t-shirt (and more)

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Dec 17, 2020
TWiV 693: Vax to the future
01:55:05

On this episode, FDA EUA for Pfizer mRNA vaccine, efficacy of AstraZeneca ChAdOx1 COVID-19 vaccine, and an orally administered drug that blocks SARS-CoV-2 transmission in ferrets.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

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Weekly Science Picks

Dickson 2020 In Photos: A Year Like No Other
BrianneCooking for Geeks
AlanOn Food and Cooking
RichNASA Artemis (Wiki)
Vincent The virus, the bats, and us

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Dec 13, 2020
TWiV 692: COVID-19 clinical update #40 with Dr. Daniel Griffin
38:12

Daniel Griffin provides his weekly clinical report on COVID-19, including the anticipated EUA for the Pfizer mRNA vaccine, mitigation strategies in early care and education settings, expressive aphasia, and much more.

Hosts: Daniel Griffin and Vincent Racaniello

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Links for this episode

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Dec 11, 2020
TWiV 691: SciArt with Laura Splan
02:11:55

SciArtist Laura Splan joins TWiV to reveal her transdisciplinary work that intersects science, technology, design and culture, then we discuss an inverse correlation between mumps virus antibodies induced by MMR vaccine and COVID-19 severity, and whether ivermectin is indicated for treatment of COVID-19.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Laura Splan

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Weekly Picks

Brianne – Patterns for Virus snowflakes
Kathy – 2020 Nobel Prize lectures (hepatitis C) (link to all and concert) Historical review by Harvey Alter
Rich New Data Confirm 2020 SO is Upper Centaur Rocket Booster from 1960’s (Wiki)
VincentThe Right Stuff

Listener Pick

Miikael Tiny tweak behind COVID-19 vaccines

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

 

Dec 10, 2020
TWiV 690: This is your brain on SARS-CoV-2
01:59:02

TWiV reviews the difficulties in predicting species susceptibility to SARS-CoV-2 infection by only examining the ACE2 protein, and the olfactory mucosa as a portal of entry into the central nervous system in COVID-19 patients.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

Guest: Amy Rosenfeld

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Weekly Science Picks

Dickson National Geographic best animal photos of 2020
AmyAmerican Contagions: Epidemics and the law from Smallpox to COVID-19 by John Fabian Witt
AlanHamSCI citizen science organization
RichDeepMind’s AI makes gigantic leap in solving protein structures
VincentArmy Ants: Nature’s Ultimate Social Hunters by Daniel Kronauer

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Dec 06, 2020
TWiV 689: COVID-19 clinical update #39 with Dr. Daniel Griffin
37:11

Daniel Griffin provides his weekly clinical report on COVID-19, including analysis of vitamin D levels in patients, information on Moderna and Pfizer vaccines, distribution plans suggested by ACIP, and more.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Dec 05, 2020
TWiV 688: We put COVID-19 papers through a sieve
01:50:30

TWiV 688: We put COVID-19 papers through a sieve

December 2, 2020

On this episode, UK grants EUA for Pfizer vaccine, advice for CDC on who to immunize first, news from Das Coronavirus, SARS-CoV-2 protease regulates innate responses, and viral mRNAs are not an indication of viral replication.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Links for this episode

Weekly Picks

BriannePedromics
KathyGlobal map at Mars opposition
RichJaneway’s Immunobiology
VincentJanet Iwasa’s Animation Lab

Listener Pick

Cheryl – BioRender.com holiday card templates

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Dec 03, 2020
TWiV 687: Peter Hotez sticks to the vax
02:18:04

Peter Hotez joins TWiV to discuss the COVID-19 pandemic, including why it went out of control in the US, the hijacking of public health practices by anti-science extremist groups, prospects for control, and whether we will be prepared for the next one.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Peter Hotez

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Weekly Science Picks

Dickson The World’s First Energy-Positive Hotel to Open in Norway
Brianne The Food Lab: Better Home Cooking Through Science
Alan ACIP’s ethical principles for COVID-19 vaccine allocation
RichThe Mandolorian
VincentT. rex and the Crater of Doom by Walter Alvarez

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Nov 29, 2020
TWiV 686: COVID-19 clinical update #38 with Dr. Daniel Griffin
34:26

Daniel Griffin provides his weekly clinical report on COVID-19, including new post-exposure guidelines from CDC, clinical trials of Remdesivir and convalescent plasma, FDA EUA for baricitinib and Regeneron’s monoclonal antibody and more.

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Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Nov 28, 2020
TWiV 685: Pandemicky
01:50:25

The TWiVers analyze efficacy of the AstraZeneca/Oxford adenovirus vectored vaccine, SARS-CoV-2 did not infect miners who became ill 8 years ago after cleaning bat guano from a cave in Yunnan Province, and induction of antigen-specific germinal center responses and production of neutralizing antibody by SARS-CoV-2 mRNA vaccine but not purified protein.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Links for this episode

Weekly Picks

Brianne Types of Scientists Coloring Book
KathySouth Pole video
RichSteve Jobs by Walter Isaacson
VincentScreenology (I interviewed Deb Sklut here)

Listener Pick

MonaAd5 vector and podcast with ImmunityBio founder

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Nov 26, 2020
TWiV 684: Persistence of SARS-CoV-2 immune memory
03:04:01

Daniel Griffin provides a clinical report on COVID-19, and Shane Crotty explains a study of antibodies, B cells and T cells in patients which suggests that immunological memory to SARS-CoV-2 might be long-lived.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

Guests: Daniel Griffin and Shane Crotty

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Weekly Science Picks

Dickson Benoit Mandlebrot’s 96 birthday
Brianne#BlackinImmunoWeek
Rich GoISSWatch ISS Tracking; Spot The Station (NASA)
VincentMicrobes Rule

Listener Pick

Agda Sandwalk

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Nov 22, 2020
TWiV 683: Two COVID-19 mRNA vaccines
01:59:11

On this episode of TWiV, mRNA vaccines from Moderna and Pfizer show over 90% efficacy, prothrombotic auto-antibodies in serum of COVID-19 patients, and the whereabouts of SARS-CoV-2 in the human body.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks

BriannePicture a Scientist
KathyColors of the Moon and Word that hasn’t changed
RichNASA YouTube channel
VincentLaura Splan science art

Listener Pick

MonaAd5 vector and podcast with ImmunityBio founder

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Nov 19, 2020
TWiV 682: Kate Rubins from the International Space Station
28:36

From Expedition 64 of International Space Station, Flight Engineer Kate Rubins joins TWiV to discuss experiments that she is working on, including cell cultures, genome sequencing, and plant growth.

Hosts: Vincent Racaniello and Rich Condit

Guest: Kate Rubins

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Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Nov 17, 2020
TWiV 681: Crowley, coats, and cross-reactive antibodies
02:58:39

Daniel Griffin provides a clinical report on COVID-19, Kathleen Crowley explains the role of Environmental Health & Safety departments, update on SARS-CoV-2 transmission in farmed mink, and the presence of pre-existing antibodies to SARS-CoV-2 in unexposed individuals.

Guests: Daniel Griffin and Kathleen A. Crowley

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Weekly Science Picks

DicksonOSIRIS-REx | NASA
Brianne Virtual Science Museum Tours
AlanRing Fit Adventure
RichBUGSS Baltimore Underground Science Space
VincentTrilobite glassworks

Listener Pick

Gina and JoeCOVID Fan Tutte

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Nov 15, 2020
TWiV 680: Long-term COVID and ME/CFS
01:52:14

Mady, Fiona, and David join TWiV to discuss patients with long-term COVID and similarities and differences with ME/CFS.

Guests: Mady Hornig, Fiona Lowenstein, and David Tuller

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Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Nov 12, 2020
TWiV 679: Mink, mutation, and myocytes
02:37:24

Daniel Griffin provides a clinical report on COVID-19, Slovlakia’s plan to test all adults for SARS-CoV-2 infection, viral variants arising in Danish mink and their potential threat to humans, why it is unethical to carry out challenge trials, Nipah virus dynamics in bats and spillovers into humans, and direct cardiac damage by spike-mediated cardiomyocyte fusion.

Guests: Daniel Griffin and Amy Rosenfeld

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Weekly Science Picks

DicksonCNN News
AmyI voted and Grace for President
AlanThe Story of More by Hope Jahren
RichOSIRIS-REx and 101955 Bennu
VincentThe Vexed Muddler

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Nov 08, 2020
TWiV 678: Fishing for viruses with Nels Elde
01:51:12

Nels joins TWiV to reveal the discovery of a picornavirus of zebrafish by measuring immune responses in the host, genome sequence analysis of the White House COVID-19 outbreak, and a six-fold higher SARS-CoV-2 exposure rate than reported cases in German children.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guest: Nels Elde

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Weekly Science Picks

Kathy –  Why art is important and Tagging an asteroid
RichVendee Globe
VincentPrePubMed

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Nov 05, 2020
TWiV 677: Does antibody really know what time it is?
02:41:15

Daniel Griffin provides a clinical report on COVID-19, then we discuss rapid deployment of SARS-CoV-2 testing by research laboratories in San Francisco, longitudinal observation of antibodies to SARS-CoV-2 in patients, and listener questions on vaccines, loss of smell, face masks, and more.

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Weekly Science Picks

DicksonComedy Wildlife Photography
BrianneEd Yong – Science reporting during a pandemic
AlanTree Story by Valerie Trouet
Rich Boundless Body Radio Bethany and Casey Ruff
VincentWearing is Caring

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Nov 01, 2020
TWiV 676: Tragic gene flow from Neanderthals
02:00:05

In this episode we explain how regions of the human genome associated with severe COVID-19 are identified, the finding that one of these regions was inherited from Neanderthals, and prolonged SARS-CoV-2 reproduction in an immunocompromised patient.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker

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Links for this episode

Weekly Science Picks

Brianne Kids Meet a Virologist
Kathy –  Harvard glass marine invertebrates 3D online
Rich Chernobyl fungi
VincentArtologica

Listener Pick

JustinTotally Under Control

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Oct 29, 2020
TWiV 675: Forget what you've herd about immunity
02:54:21

Daniel Griffin provides a clinical report on COVID-19, then we discuss Bill Foege’s letter to CDC director Robert Redfield, the false promise of herd immunity for COVID-19, secret blueprints for SARS-CoV-2 vaccine trials released, and neuropilin-1 as a possible entry protein for the virus.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Daniel Griffin

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Weekly Science Picks

Dickson Nikon Small World Photography Competition
BrianneModeling Herd Immunity for measles
Alan Small Gods by Terry Pratchett
RichBoundless Body Radio Bethany and Casey Ruff
VincentThe Twenty-One Balloons by William Pene du Bois

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Oct 25, 2020
TWiV 674: In the company of coronaviruses with Lisa Gralinski
01:58:45

Lisa joins TWiV to discuss her research on the pathogenesis of SARS-CoV, MERS-CoV, and SARS-CoV-2, including work on vaccines and an antiviral, then we review the SARS-CoV-2 spike protein as a potential analgesic, and listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker

Guest: Lisa Gralinski

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Weekly Science Picks

Brianne The Lonely Pipette Podcast: Mentoring with Harmit Malik
Kathy –  Dr. Boyd the Chemist one and two  GREAT short videos one and two,  How to read an old school thermometer, New Marvel storyline  Wear a Mask parody of Be My Guest
Rich Clear+Vivid with Alan Alda
VincentImmune 36: Aberrant immunity in COVID-19

Listener Pick

Ryan Dr. Fauci on politicization of pandemic

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

 

Oct 22, 2020
TWiV 673: Wake up and smell the pandemic
02:40:48

Daniel Griffin provides a clinical report on COVID-19, we debunk the Great Barrington Declaration, and discuss smell and taste changes as early indicators of the pandemic, vascular disease and thrombosis in SARS-CoV-2 infected humans and rhesus macaques, and the ability of the swine pathogen SADS-CoV to infect human respiratory tract cells.

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Weekly Science Picks

DicksonThe Age of Nature
Brianne Virologist, Immunologist, Science Communicator pins and Virus Earrings
Alan Sharks, Squalene, and a SARS-CoV-2 Vaccine
Rich6th Annual Science Mill Benefit
VincentThe Evolution of Infectious Disease by Paul Ewald

Intro music is by Ronald Jenkees

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Oct 18, 2020
TWiV 672: Black in Microbiology with Ari Kozik and Kishana Taylor
02:05:59

Ari and Kishana, two of the founders of Black in Microbiology, join TWiV to discuss the goals of the organization, then we review pauses of J&J and Lilly COVID-19 vaccine trials, preclinical studies of Regeneron's SARS-CoV-2 monoclonal antibody cocktail, reinfection of a patient in Nevada, and listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker

Guest: Ari Kozik and Kishana Taylor

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Weekly Science Picks

Brianne - A Lab of One's Own by Rita Colwell
Kathy –  Endonym map
Rich - “The Coronavirus Unveiled” by Carl Zimmer
Vincent - Principles of Virology 5th Edition

Listener Pick

Les - Coronavirus cake
Mary - Choir finds a way to sing

Intro music is by Ronald Jenkees

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Oct 15, 2020
TWiV 671: Prizes, polio, and a pandemic puzzle
02:49:43

Daniel Griffin provides a clinical report on COVID-19, then Amy joins us to discuss the 2020 Chemistry Nobel Prize for gene editing using CRISPR/Cas9, continuing circulation of poliovirus in Afghanistan, inborn errors of interferon in patients with severe COVID-19, and listener questions.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Guests: Daniel Griffin and Amy Rosenfeld

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Weekly Science Picks

Amy - Coronavirus : A book for children by Kate Wilson and Nia Roberts
Alan - Lost Prologue
Rich -RAPS COVID-19 vaccine tracker
Vincent - A Crack in Creation by Doudna and Sternberg and Sternberg on TWiM 184

Intro music is by Ronald Jenkees

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Oct 11, 2020
TWiV 670: Coronavirus vaccine preparedness with Kizzmekia Corbett
02:07:19

Kizzmekia Corbett joins TWiV to review her career and her work on respiratory syncytial virus, influenza virus, and coronaviruses and coronavirus vaccines, including her role in development and testing of a spike-encoding mRNA vaccine, and then we review the Nobel Prize for discovery of hepatitis C virus.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker

Guest: Kizzmekia Corbett

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Weekly Science Picks

Brianne - COVID-19 in Molecular Detail for Teaching
Kathy – Mars shining brightest since 2003
Rich - Lost Prologue
Vincent - Girl from Ipanema is weirder than you thought

Listener Pick

Sandra - Learn Medical Research

Intro music is by Ronald Jenkees

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Oct 08, 2020
TWiV Special: Presidential COVID-19 with Dr. Daniel Griffin
34:04

Daniel Griffin discusses President Trump's case of COVID-19, including the clinical course, the medications he received and why, and expectations for the next few weeks.

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Intro music is by Ronald Jenkees

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Oct 05, 2020
TWiV 669: All the wrong COVID-19 moves
03:00:09

Daniel Griffin provides a clinical report on COVID-19, including a discussion of the role of vitamin D in COVID-19, Michael and Christopher explain why we have made all the wrong moves during the pandemic, evidence that the D614G amino acid change improves transmission in hamsters, and listener questions.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

Guests: Daniel Griffin, Michael B. Yaffe, and Christopher D. Barrett

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Weekly Science Picks

Dickson - Why we should all wear masks
Brianne - Milestones in Vaccines
Rich - Wallpaper/fabric designs by David Goodsell
Vincent - Das Coronavirus bullet points and a new t-shirt

Listener Pick

Justin - COVID Alert NY App | Department of Health

Intro music is by Ronald Jenkees

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Oct 04, 2020
TWiV 668: Mice, bats, and coronaviruses with Tony Schountz
01:46:21

Tony Schountz joins TWiV to explain the work of his laboratory showing that deer mice can be infected with and transmit SARS-CoV-2, and how his colony of Jamaican fruit bats is being used to understand their response to virus infections.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker

Guest: Tony Schountz

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Weekly Science Picks

Brianne - Virus Masks
Kathy – UV in the vineyards (video)
Rich - Great White Shark Attack
Vincent - Smart WiFi garage door opener

Intro music is by Ronald Jenkees

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Oct 01, 2020
TWiV 667: Building a better virus trap
02:45:17

Daniel Griffin provides a clinical report on COVID-19, review of the phase I and II trials of the Russian prime-boost vaccine, a mouse model that recapitulates age-dependent severe disease, and listener questions.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

Guest: Daniel Griffin

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Weekly Science Picks

Dickson - Rewilding Europe
Alan - How to Do Nothing by Jenny Odell
Rich - Gene drive engineered mosquitoes
Vincent - TWiEVO 60 with 12 guests!

Intro music is by Ronald Jenkees

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Sep 27, 2020
TWiV 666: A far-UVC light bulb went off for David Brenner
02:09:16

David Brenner joins TWiV to explain how far-UVC lights could provide protection from SARS-CoV-2 and other airborne viruses in public places, solutions to face mask fogging, transmission during airplane flights, and listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker

Guest: David Brenner

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Sep 24, 2020
TWiV 665: This half-week in coronavirology
02:56:03

Daniel Griffin provides a clinical report on COVID-19, superspreading potential of SARS-CoV-2 in Hong Kong, structure of virion glycoprotein of a commmon cold coronavirus reveals changes driven by prolonged circulation in humans, and listener email.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Daniel Griffin

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Intro music is by Ronald Jenkees

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Sep 20, 2020
TWiV 664: TWiV is for the dogs
02:01:49

On this mid-week edition, does it matter that SARS-CoV-2 is mutating, seasonal coronavirus immunity is short-lived, another bogus claim that the virus was produced in a laboratory (it came from Nature), and answers to listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker

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Links for this episode

  • Coronavirus is mutating (Nature)
  • Seasonal CoV immunity is short (Nat Med)
  • Sorry, no link to the fake science document!
  • Letters read on TWiV 664
  • Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

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Sep 17, 2020
TWiV 663: The joy of vax
02:36:57

Daniel Griffin provides a clinical report on COVID-19, including vaccines, Alan summarizes a vaccine webinar on the most advanced US trials, a nidovirus from snapping turtles, longevity of memory B cells in recovered patients, and listener email.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Daniel Griffin

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Intro music is by Ronald Jenkees

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Sep 13, 2020
TWiV 662: Principals of Principles, Fifth Edition
52:23

The authors of the textbook Principles of Virology gather to reveal new additions to the fifth edition, including a new author, study questions, and a chapter on therapeutic viruses.

Host: Vincent Racaniello

Guests: Jane Flint, Anna Marie Skalka, Glenn F. Rall, and Theodora Hatziioannou

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Links for this episode

  • Purchase PoV 5e Volumes 1 + 2 (link)
  • Purchase PoV 5e Volume 1 (link)
  • Purchase PoV 5e Volume 2 (link)

Intro music is by Ronald Jenkees

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Sep 11, 2020
TWiV 661: SWAG with Ralph Baric
01:55:51

Ralph Baric returns to TWiV to provide an update on the COVID-19 resurgence in the US, monoclonal antibodies, antiviral drugs, vaccines, immunity and reinfection, reopening schools, and what will happen this fall.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker

Guest: Ralph Baric

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Intro music is by Ronald Jenkees

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Sep 10, 2020
TWiV 660: In case of emergency finish the trial
02:38:47

Daniel Griffin provides a clinical report on COVID-19, then we discuss decline of virus-specific bone marrow B cells within a year after influenza vaccination, the push to release SARS-CoV-2 vaccines before completion of phase 3 trials, and absence of evidence for infectious virus in aerosols.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Daniel Griffin

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Intro music is by Ronald Jenkees

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Sep 06, 2020
TWiV 659: Sloppy coronavirus immunity with Christian Drosten
02:00:00

Christian Drosten returns to TWiV to provide an update on the COVID-19 situation in Germany, and general thoughts on testing, immunity, vaccines, therapeutics, epidemiology, reopening schools, and what will happen this fall.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

Guest: Christian Drosten

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Intro music is by Ronald Jenkees

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Sep 03, 2020
TWiV 658: Everyone needs a H.E.A.R.T.
02:21:07

Daniel Griffin provides a clinical report on COVID-19, then we discuss CDC softening testing guidelines, Moderna vaccine phase I results in older people, Abbott's $5 rapid antigen test, and reinfection with a distinct SARS-CoV-2 isolate, followed by listener email.

Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, and Rich Condit

Guest: Daniel Griffin

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Intro music is by Ronald Jenkees

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Aug 30, 2020
TWiV 657: Shane Crotty on SARS-CoV-2 immunity
02:13:23

Immunologist Shane Crotty joins TWiV to discuss the antibody and T cell responses to infection with SARS-CoV-2, followed by answers to listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Shane Crotty

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Intro music is by Ronald Jenkees

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Aug 27, 2020
TWiV 656: See, it can be done!
02:20:48

Daniel Griffin provides a clinical report on COVID-19, surgeons Lisa Smith and David Bruce detail how they have helped their Chattanooga community during the pandemic, then we discuss racial and ethnic disparities among COVID-19 cases, no more premarket review of laboratory developed tests by FDA; and emergency use authorization of convalescent plasma is on hold.

Hosts: Vincent Racaniello, Dickson DespommierRich Condit, and Brianne Barker

Guests: Daniel Griffin, Lisa A. Smith, and W. David Bruce

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Intro music is by Ronald Jenkees

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Aug 23, 2020
TWiV 655: Minority health with Robert Fullilove
02:27:23

Sociomedical scientist Robert Fullilove joins TWiV to discuss disparities in minority health; FDA announces an EUA on Yale's SalivaDirect, protection of the upper and respiratory tract of mice after intranasal inoculation with an adenovirus-vectored SARS-CoV-2 spike gene, and listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Robert Fullilove

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Intro music is by Ronald Jenkees

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Aug 20, 2020
TWiV 654: TWiVering with excitement
02:35:37

Daniel Griffin provides a clinical report on COVID-19 and the convalescent plasma trial, then we answer listener questions about the Russian vaccine, choir practice, face masks (wear them!), Mina testing, transmission, and much more.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, Rich Condit, and Brianne Barker

Guests: Daniel Griffin and Chuck Knirsch

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Intro music is by Ronald Jenkees

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Aug 16, 2020
TWiV 653: Back to school with COVID-19
55:52

Alfonso, Ken, Mary and Janet join TWiV to explain their modeling of school reopening strategies during the SARS-CoV-2 pandemic.

Hosts: Vincent Racaniello and Rich Condit

Guests: Alfonso Landeros, Ken Lange, Mary E. Sehl, and Janet Sinsheimer

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Intro music is by Ronald Jenkees

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Aug 14, 2020
TWiV 652: The rules of contagion with Adam Kucharski
01:54:18

Epidemiologist Adam Kucharski joins TWiV to discuss SARS-CoV-2, including R0, incubation period, herd immunity, asymptomatic infection, superspreaders, children as drivers of pandemics, and how this one will end.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Adam Kucharski

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Intro music is by Ronald Jenkees

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Aug 13, 2020
TWiV 651: FDA rules with Denise Esposito
02:43:55

Daniel Griffin provides a clinical report on COVID-19, then former FDA Chief of Staff to the Commissioner Denise Esposito joins us to explain the challenges in approving vaccines, antiviral drugs, and diagnostic tests during a pandemic, followed by answers to listener questions.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, Rich Condit, and Brianne Barker

Guests: Daniel Griffin and Denise Esposito

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Intro music is by Ronald Jenkees

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Aug 09, 2020
TWiV 650: Virology is infinite
02:02:03

In this mid-week episode of Earth's Virology Podcast, we analyze SARS-CoV-2 transmission among youths at a summer camp, adaptation to mice by passage, the importance of T cells for recovery from COVID-19, and listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Science Picks

KathyBBC Witness History, Maurice Hilleman 9 minute audio (quotes by Paul Offit) “The fastest vaccine ever developed”And APOD Picture Rocks Sun Dagger

Intro music is by Ronald Jenkees

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Aug 06, 2020
TWiV 649: Ohio State viral
01:45:01

Vincent visits Ohio State University (March 2020) and speaks with Shan-Lu, David, Amanda, Mark, Matt, Chris, and Qiuhong about their careers and their work on retroviruses, hepatitis C virus, coronaviruses, paramyxoviruses, and environmental viruses.

Host: Vincent Racaniello

Guests: Shan-Lu Liu, David Bisaro, Amanda Panfill, Mark Peeples, Matt Sullivan, Chris Walker, Qiuhong Wang

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Intro music is by Ronald Jenkees

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Aug 04, 2020
TWiV 648: Life is for learning
02:55:23

Daniel Griffin provides a clinical report on COVID-19, followed by a review of the findings that children shed as much SARS-CoV-2 viral RNA from the respiratory tract as older patients, the lineage giving rise to SARS-CoV-2 has been circulating in bats in China for decades, and answers to listener questions.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, Rich Condit, and Brianne Barker

Guest: Daniel Griffin and Chuck Knirsch

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Intro music is by Ronald Jenkees

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Aug 02, 2020
TWiV 647: Testing is our way out of this crisis
01:54:21

In this mid-week TWiV, children under 10 do transmit SARS-CoV-2, why hydroxychloroquine does not work for treating COVID-19, scale-up of diagnostic testing, explanation of LAMP testing, and listener questions.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

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Weekly Science Picks

Kathy - Vertical Farms Fill a Tall Order by Dickson Despommier and APOD
Rich - Mars in 4K

LIstener Pick

Christiane - ZSK - Ich habe Besseres zu tun (Official Video) Drosten
Jon - The Logic of Doomsday

Intro music is by Ronald Jenkees

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Jul 30, 2020
TWiV 646: Virocentricity II with Eugene Koonin
01:55:57

From the NIH campus (recorded February 2020) Vincent and Rich meet with Eugene Koonin to discuss his theories on the evolutionary origins of viruses.

Hosts: Vincent Racaniello and Rich Condit

Guest: Eugene Koonin

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Intro music is by Ronald Jenkees

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Jul 28, 2020
TWiV 645: Lions and tigers and zookeepers (oh my)
02:43:13

Daniel Griffin provides a clinical report on COVID-19, followed by a review of the State Department document on the Wuhan BSL-4 laboratory, the report on infection of tigers and lions in the Bronx Zoo, and, answers to listener questions.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, Rich Condit, and Brianne Barker

Guest: Daniel Griffin

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Intro music is by Ronald Jenkees

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Jul 26, 2020
TWiV 644: Don't let perfect be the enemy of good
01:55:14

In this mid-week edition, identifying flawed research before it becomes dangerous, Michigan governor tells America to mask-up, Pfizer mRNA vaccine gets $1.95 billion from Warp Speed, preliminary phase I/II results of the ChAdOx1 SARS-CoV-2 vaccine, answers to listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Intro music is by Ronald Jenkees

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Jul 23, 2020
TWiV 643: Bernie Moss, the real Poxdoc
01:51:52

From the NIH campus (recorded February 2019) Vincent and Rich meet with Bernie Moss to hear about his training and his remarkable 50-year-plus career working on poxviruses.

Hosts: Vincent Racaniello and Rich Condit

Guest: Bernie Moss

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Intro music is by Ronald Jenkees

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Jul 21, 2020
TWiV 642: Bringin' in 50 keys of spike mRNA
02:39:37

Daniel Griffin provides a clinical update on COVID-19, then we discuss phase I preliminary results of the SARS-CoV-2 mRNA vaccine, factors associated with death in 17 million patients, and answer listener questions.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guests: Daniel Griffin and Chuck Knirsch

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Intro music is by Ronald Jenkees

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Jul 19, 2020
TWiV 641: COVID-19 with Dr. Anthony Fauci
36:26

Dr. Anthony Fauci joins TWiV to discuss SARS-CoV-2 transmission, testing, immunity, pathogenesis, vaccines, and preparedness.

Hosts: Vincent Racaniello and Rich Condit

Guest: Dr. Anthony Fauci

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Dr. Fauci was previously on TWiV 219

Intro music is by Ronald Jenkees

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Jul 17, 2020
TWiV 640: Test often, fast turnaround, with Michael Mina
01:45:41

Michael Mina joins TWiV to reveal why frequent and rapid SARS-CoV-2 testing is more important than accuracy, how a daily $1 rapid test could control the pandemic, and why group testing works.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guests: Michael Mina

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Intro music is by Ronald Jenkees

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Jul 16, 2020
TWiV 639: Virology Nobel Prizes with Erling Norrby part 2
01:47:43

Vincent and Erling resume their discussion of virology Nobel Prizes, focusing on awards for research on tumor viruses, bacteriophages, virus structure, reverse transcriptase, hepatitis B virus, HIV-1, human papillomaviruses and much more.

Host: Vincent Racaniello

Guest: Erling Norrby

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Intro music is by Ronald Jenkees

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Jul 14, 2020
TWiV 638: Do, there is no try
02:44:15

Daniel Griffin provides a clinical update on COVID-19, then Viviana Simon joins to review serological assays developed at Mt. Sinai for SARS-CoV-2 infection, tracking the outbreak in NYC, and listener questions.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

Guests: Viviana Simon, Daniel Griffin and Chuck Knirsch

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Intro music is by Ronald Jenkees

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Jul 12, 2020
TWiV 637: Clearing the fog of ignorance
01:49:21

In this episode, approval of an Ad5 vectored SARS-CoV-2 vaccine for the military in China, description and clinical trials of a Novavax vaccine joining Operation Warp Speed, prevalence of SARS-CoV-2 in Spain, shedding and transmissibility of the virus, and listener email.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

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Intro music is by Ronald Jenkees

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Jul 09, 2020
TWiV 636: Georgia State viral
01:52:33

From Georgia State University, Vincent speaks with Chris, Andrew, Priya, and Richard about their careers and their work on Ebolaviruses, rotavirus, and antiviral drug development.

Host: Vincent Racaniello

Guests: Chris Basler, Andrew Gewirtz, Priya Luthra, and Richard Plemper

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Intro music is by Ronald Jenkees

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Jul 07, 2020
TWiV 635: Mask hysteria
02:32:49

Daniel Griffin provides a clinical update on COVID-19, then we review SARS-CoV-2 shedding in children, how to resume school safely, the need for widespread testing and wearing face masks, and much more, including listener email.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guests: Daniel Griffin and Chuck Knirsch

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Intro music is by Ronald Jenkees

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Jul 05, 2020
TWiV 634: 1000 hours of the sunlight of TWiV
02:00:02

TWiV reviews a new H1N1 swine influenza virus from China with pandemic potential, Ad5 vectored SARS-CoV-2 oral vaccine candidate, Operation Warp Speed vaccine candidates, FDA guidance on vaccine approval, and answer listener email.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker

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Intro music is by Ronald Jenkees

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Jul 02, 2020
TWiV 633: Singapore viral
01:32:47

From DukeNUS Medical School, Vincent speaks with Ashley, Sheemei, Eng Eong and Dahai about their careers and their research on flaviviruses and sensing of viral RNA.

Host: Vincent Racaniello

Guests: Sheemei Lok, Dahai Luo, Eng Eong Ooi, and Ashley St. John

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Intro music is by Ronald Jenkees

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Jun 30, 2020
TWiV 632: Countering a miasma of anti-think
02:24:21

Daniel Griffin provides a clinical update on COVID-19, then we review SARS-CoV-2 infections in non-humans, vesicular stomatitis in Kansas horses, and answer listener questions.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler and Brianne Barker

Guests: Daniel Griffin and Chuck Knirsch

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Intro music is by Ronald Jenkees

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Jun 28, 2020
TWiV 631: Lots of eggs in the spike basket
01:59:21

Vincent, Rich, and Brianne discuss a study estimating the fraction of symptoms and severe disease after SARS- CoV-2 infection, cellular immune responses without seroconversion during interfamilial infections, and answer listener email.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

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Intro music is by Ronald Jenkees

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Jun 25, 2020
TWiV 630: Singapore Environmental Health Institute
48:35

From the Environmental Health Institute in Singapore, Vincent speaks with Director Lee Ching Ng about their work to control viral infectious diseases, including the controlled release of mosquitoes containing Wolbachia endosymbionts to inhibit viral transmission.

Host: Vincent Racaniello

Guest: Lee Ching Ng

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Jun 24, 2020
TWiV 629: Coronavirus update, pandemic sitrep
02:38:29

Daniel Griffin provides a clinical update on COVID-19, including analysis of the dexamethasone trial, and then we discuss two Ebolavirus outbreaks in DRC, clinical and virological aspects of asymptomatic SARS-CoV-2 infections, age-dependent effects on transmission, and answer listener email.

Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove

Guests: Daniel Griffin and Chuck Knirsch

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Intro music is by Ronald Jenkees

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Jun 21, 2020
TWiV 628: Physical distance for COVID-19
01:52:49

Vincent and Rich discuss the SARS-CoV-2 D614G amino acid change in the spike glyprotein, duration of infectious virus shedding from patients, virus transmission among hamsters infected in the laboratory, and tackle listener email.

Hosts: Vincent Racaniello and Rich Condit

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Intro music is by Ronald Jenkees

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Jun 18, 2020
TWiV 627: Singapore National Centre for Infectious Diseases
01:30:41

Vincent visits the National Centre for Infectious Diseases and speaks with Executive Director Leo Yee-Sin and Consultant Nancy Tee about the main hub for both clinical treatment of infectious diseases and outbreak management in Singapore.

Host: Vincent Racaniello

Guests: Leo Yee-Sin and Nancy Tee

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Intro music is by Ronald Jenkees

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Jun 17, 2020
TWiV 626: Ralph Baric and fancy ferrets
02:42:51

Daniel Griffin provides a clinical update on COVID-19, then Ralph Baric joins TWiV to discuss SARS-CoV-2 transmission, vaccines, diagnostic tests, and a new animal model from his laboratory that does not use transgenic mice.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guests: Daniel Griffin, Chuck Knirsch, and Ralph Baric

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Intro music is by Ronald Jenkees

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Jun 14, 2020
TWiV 625: Fred Murphy, virologist for all seasons
01:39:35

Vincent and Rich visit Fred Murphy to hear about his wide-ranging career in virology, spanning many institutions, involving dangerous viruses like rabies virus, Ebolavirus (he took that famous iconic image), Marburg virus, Lassa virus, coronaviruses, and later writing a history of the field.

Hosts: Vincent Racaniello and Rich Condit

Guest: Frederick A. Murphy

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Intro music is by Ronald Jenkees
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Jun 11, 2020
TWiV 624: SeXX matters with Sabra Klein
02:02:33

Daniel Griffin provides a clinical update on COVID-19, then Sabra Klein joins us to discuss the effect of sex, gender, and age on viral infectious disease, including COVID-19.

Hosts: Vincent Racaniello,Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker

Guests: Daniel Griffin, Chuck Knirsch, and Sabra Klein

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Intro music is by Ronald Jenkees

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Jun 07, 2020
TWiV 623: Bats and coronaviruses with Peter Daszak
01:21:59

Peter Daszak joins TWiV to explain the work of EcoHealth Alliance in surveillance of bats in China for SARS-related coronaviruses to provide the information needed to prevent future pandemics, and why NIH recently withdrew financial support for their work.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Peter Daszak

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Intro music is by Ronald Jenkees

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Jun 04, 2020
TWiV 622: Nonhuman primate model for COVID-19 with Emmie de Wit
01:07:43

Emmie de Wit joins TWiV to explain her work on the pathogenesis of infection with SARS-CoV-2 in rhesus macaques, including studies on remdesivir and vaccine candidate.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

Guest: Emmie de Wit

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Intro music is by Ronald Jenkees

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Jun 02, 2020
TWiV 621: An era of COVID-19 poppycock
02:14:35

Daniel Griffin provides a clinical update on COVID-19, then we review an Ad5 vectored SARS-CoV-2 vaccine, reports on remdesivir and hydroxychloroquine, a drug repurposing study, why some patients infect many others, reducing viral transmission, and much more, including listener email.

Hosts: Vincent Racaniello,Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker

Guests: Daniel Griffin and Chuck Knirsch

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Intro music is by Ronald Jenkees.

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May 31, 2020
TWiV 620: Antibodies and T cells in COVID-19 patients
01:50:51

Jon Yewdell returns to explain studies on detection of antibodies and T cell epitopes in patients who have recovered from COVID-19.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

Guest: Jon Yewdell

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Intro music is by Ronald Jenkees.

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May 29, 2020
TWiV 619: Recombination led to emergence of SARS-CoV-2
01:11:31

Raul Rabadan joins TWiV to explain the use of computational biology to demonstrate how recombination and mutation led to emergence of SARS-CoV-2.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

Guest: Raul Rabadan

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Intro music is by Ronald Jenkees.

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May 27, 2020
TWiV 618: Nipah virus at 20
58:21

From the Nipah Virus International Conference in Singapore, Vincent speaks with meeting participants about the history of the first Nipah virus outbreak, lessons learned from Hendra virus, surveillance of bats for viruses, and the development of a vaccine.

Hosts: Vincent Racaniello

Guests: John Mackenzie, Jon Epstein, Eun-Chung Park, and Linfa Wang

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Intro music is by Ronald Jenkees.

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May 26, 2020
TWiV 617: Coronavirus Times
02:32:20

Daniel Griffin provides a clinical update on COVID-19, then we review TETRIS by Paterson NJ, modeling the effects of intervention in the US on cases and deaths, mixing PCR and serology data, and much more, including listener email.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker

Guest: Daniel Griffin

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Intro music is by Ronald Jenkees.

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May 24, 2020
TWiV 616: Singing about coronavirus
01:43:12

Vincent, Kathy and Rich discuss COVID-19 research paper overload, Moderna's mRNA vaccine Phase I results, increase of ACE2 RNA by cigarette smoke, and answer listener questions.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

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Intro music is by Ronald Jenkees.

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May 21, 2020
TWiV 615: Peter Daszak of EcoHealth Alliance
35:53

Vincent speaks with Peter Daszak, President of EcoHealth Alliance, a global nonprofit organization dedicated to protecting wildlife and public health from the emergence of disease.

Hosts: Vincent Racaniello

Guests: Peter Daszak

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Intro music is by Ronald Jenkees.

20% off The Invisible ABCs for TWiV listeners! Use promo code: ABC20 at checkout.

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May 19, 2020
TWiV 614: COVID Tetris - Test, trace, isolate
02:47:27

Daniel Griffin provides a clinical update on COVID-19, then we review results showing requirement for the furin site in the SARS-CoV-2 spike for replication, US state vaccine exemptions, concerns with a rapid diagnostic test, and answers to listener questions.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker

Guest: Daniel Griffin

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Intro music is by Ronald Jenkees.

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May 17, 2020
TWiV 613: Jenner, vaccines, and COVID-19
01:45:37

Vincent, Kathy and Rich explain the Jenner Institute's SARS-CoV-2 vaccine, the NIH decision to stop the Remdesivir study, and answer listener questions.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

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Intro music is by Ronald Jenkees.

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May 14, 2020
TWiV 612: CEPI, preventing the next pandemic
36:28

From the Nipah Virus International Conference in Singapore, Vincent speaks with Richard Hatchett, CEO of CEPI, about its mission to stimulate and accelerate the development of vaccines against emerging infectious diseases.

Hosts: Vincent Racaniello

Guests: Richard Hatchett and Linfa Wang

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Intro music is by Ronald Jenkees.

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May 12, 2020
TWiV 611: Corona and crowns
02:25:19

Daniel Griffin provides a weekly clinical update on COVID-19, then Michael Schmidt discusses how dentistry can be safely practiced during a pandemic, followed by answers to listener questions.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guests: Daniel Griffin and Michael Schmidt

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Intro music is by Ronald Jenkees.

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May 10, 2020
TWiV 610: Coronavirus FAQ
01:38:53

The TWiV team summarizes serology-based tests for SARS-CoV-2, lack of effect of ACE inhibitors or ARBs on COVID-19 severity, and answers listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Intro music is by Ronald Jenkees.

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May 07, 2020
TWiV 609: A coronavirus chronology with Susan Weiss
01:14:41

Susan Weiss recalls some of her 40 years of research on coronaviruses, including mouse hepatitis virus, MERS-CoV, and now SARS-CoV-2.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Susan Weiss

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Intro music is by Ronald Jenkees.

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May 03, 2020