This Week in Virology

By Vincent Racaniello

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Subscribers: 734
Reviews: 4


 May 29, 2020

excellent
 Apr 23, 2020
great information

Reed
 Jan 15, 2020
amazing in depth podcast on the nuts and bolts of all kinds of viruses. expect in depth discussions of papers by experienced scientists with a decent sense of humour. I can follow along most details even though I have not studied virology.


 May 31, 2019

Description

This Week in Virology is a netcast about viruses - the kind that make you sick.

Episode Date
TWiV 637: Clearing the fog of ignorance
01:49:21

In this episode, approval of an Ad5 vectored SARS-CoV-2 vaccine for the military in China, description and clinical trials of a Novavax vaccine joining Operation Warp Speed, prevalence of SARS-CoV-2 in Spain, shedding and transmissibility of the virus, and listener email.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

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Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Jul 09, 2020
TWiV 636: Georgia State viral
01:52:33

From Georgia State University, Vincent speaks with Chris, Andrew, Priya, and Richard about their careers and their work on Ebolaviruses, rotavirus, and antiviral drug development.

Host: Vincent Racaniello

Guests: Chris Basler, Andrew Gewirtz, Priya Luthra, and Richard Plemper

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Intro music is by Ronald Jenkees

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Jul 07, 2020
TWiV 635: Mask hysteria
02:32:49

Daniel Griffin provides a clinical update on COVID-19, then we review SARS-CoV-2 shedding in children, how to resume school safely, the need for widespread testing and wearing face masks, and much more, including listener email.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guests: Daniel Griffin and Chuck Knirsch

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Intro music is by Ronald Jenkees

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Jul 05, 2020
TWiV 634: 1000 hours of the sunlight of TWiV
02:00:02

TWiV reviews a new H1N1 swine influenza virus from China with pandemic potential, Ad5 vectored SARS-CoV-2 oral vaccine candidate, Operation Warm Speed vaccine candidates, FDA guidance on vaccine approval, and answer listener email.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker

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Intro music is by Ronald Jenkees

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Jul 02, 2020
TWiV 633: Singapore viral
01:32:47

From DukeNUS Medical School, Vincent speaks with Ashley, Sheemei, Eng Eong and Dahai about their careers and their research on flaviviruses and sensing of viral RNA.

Host: Vincent Racaniello

Guests: Sheemei Lok, Dahai Luo, Eng Eong Ooi, and Ashley St. John

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Intro music is by Ronald Jenkees

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Jun 30, 2020
TWiV 632: Countering a miasma of anti-think
02:24:21

Daniel Griffin provides a clinical update on COVID-19, then we review SARS-CoV-2 infections in non-humans, vesicular stomatitis in Kansas horses, and answer listener questions.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler and Brianne Barker

Guests: Daniel Griffin and Chuck Knirsch

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Intro music is by Ronald Jenkees

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Jun 28, 2020
TWiV 631: Lots of eggs in the spike basket
01:59:21

Vincent, Rich, and Brianne discuss a study estimating the fraction of symptoms and severe disease after SARS- CoV-2 infection, cellular immune responses without seroconversion during interfamilial infections, and answer listener email.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

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Intro music is by Ronald Jenkees

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Jun 25, 2020
TWiV 630: Singapore Environmental Health Institute
48:35

From the Environmental Health Institute in Singapore, Vincent speaks with Director Lee Ching Ng about their work to control viral infectious diseases, including the controlled release of mosquitoes containing Wolbachia endosymbionts to inhibit viral transmission.

Host: Vincent Racaniello

Guest: Lee Ching Ng

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Jun 24, 2020
TWiV 629: Coronavirus update, pandemic sitrep
02:38:29

Daniel Griffin provides a clinical update on COVID-19, including analysis of the dexamethasone trial, and then we discuss two Ebolavirus outbreaks in DRC, clinical and virological aspects of asymptomatic SARS-CoV-2 infections, age-dependent effects on transmission, and answer listener email.

Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove

Guests: Daniel Griffin and Chuck Knirsch

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Intro music is by Ronald Jenkees

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Jun 21, 2020
TWiV 628: Physical distance for COVID-19
01:52:49

Vincent and Rich discuss the SARS-CoV-2 D614G amino acid change in the spike glyprotein, duration of infectious virus shedding from patients, virus transmission among hamsters infected in the laboratory, and tackle listener email.

Hosts: Vincent Racaniello and Rich Condit

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Intro music is by Ronald Jenkees

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Jun 18, 2020
TWiV 627: Singapore National Centre for Infectious Diseases
01:30:41

Vincent visits the National Centre for Infectious Diseases and speaks with Executive Director Leo Yee-Sin and Consultant Nancy Tee about the main hub for both clinical treatment of infectious diseases and outbreak management in Singapore.

Host: Vincent Racaniello

Guests: Leo Yee-Sin and Nancy Tee

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Intro music is by Ronald Jenkees

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Jun 17, 2020
TWiV 626: Ralph Baric and fancy ferrets
02:42:51

Daniel Griffin provides a clinical update on COVID-19, then Ralph Baric joins TWiV to discuss SARS-CoV-2 transmission, vaccines, diagnostic tests, and a new animal model from his laboratory that does not use transgenic mice.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guests: Daniel Griffin, Chuck Knirsch, and Ralph Baric

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Intro music is by Ronald Jenkees

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Jun 14, 2020
TWiV 625: Fred Murphy, virologist for all seasons
01:39:35

Vincent and Rich visit Fred Murphy to hear about his wide-ranging career in virology, spanning many institutions, involving dangerous viruses like rabies virus, Ebolavirus (he took that famous iconic image), Marburg virus, Lassa virus, coronaviruses, and later writing a history of the field.

Hosts: Vincent Racaniello and Rich Condit

Guest: Frederick A. Murphy

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Intro music is by Ronald Jenkees
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Jun 11, 2020
TWiV 624: SeXX matters with Sabra Klein
02:02:33

Daniel Griffin provides a clinical update on COVID-19, then Sabra Klein joins us to discuss the effect of sex, gender, and age on viral infectious disease, including COVID-19.

Hosts: Vincent Racaniello,Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker

Guests: Daniel Griffin, Chuck Knirsch, and Sabra Klein

Click arrow to play
Download TWiV 624 (91 MB .mp3, 152 min)
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Intro music is by Ronald Jenkees

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Jun 07, 2020
TWiV 623: Bats and coronaviruses with Peter Daszak
01:21:59

Peter Daszak joins TWiV to explain the work of EcoHealth Alliance in surveillance of bats in China for SARS-related coronaviruses to provide the information needed to prevent future pandemics, and why NIH recently withdrew financial support for their work.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Peter Daszak

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Intro music is by Ronald Jenkees

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Jun 04, 2020
TWiV 622: Nonhuman primate model for COVID-19 with Emmie de Wit
01:07:43

Emmie de Wit joins TWiV to explain her work on the pathogenesis of infection with SARS-CoV-2 in rhesus macaques, including studies on remdesivir and vaccine candidate.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

Guest: Emmie de Wit

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Intro music is by Ronald Jenkees

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Jun 02, 2020
TWiV 621: An era of COVID-19 poppycock
02:14:35

Daniel Griffin provides a clinical update on COVID-19, then we review an Ad5 vectored SARS-CoV-2 vaccine, reports on remdesivir and hydroxychloroquine, a drug repurposing study, why some patients infect many others, reducing viral transmission, and much more, including listener email.

Show notes coming soon.

May 31, 2020
TWiV 620: Antibodies and T cells in COVID-19 patients
01:50:51

Jon Yewdell returns to explain studies on detection of antibodies and T cell epitopes in patients who have recovered from COVID-19.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

Guest: Jon Yewdell

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Intro music is by Ronald Jenkees.

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May 29, 2020
TWiV 619: Recombination led to emergence of SARS-CoV-2
01:11:31

Raul Rabadan joins TWiV to explain the use of computational biology to demonstrate how recombination and mutation led to emergence of SARS-CoV-2.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

Guest: Raul Rabadan

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Intro music is by Ronald Jenkees.

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May 27, 2020
TWiV 618: Nipah virus at 20
58:21

From the Nipah Virus International Conference in Singapore, Vincent speaks with meeting participants about the history of the first Nipah virus outbreak, lessons learned from Hendra virus, surveillance of bats for viruses, and the development of a vaccine.

Hosts: Vincent Racaniello

Guests: John Mackenzie, Jon Epstein, Eun-Chung Park, and Linfa Wang

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Intro music is by Ronald Jenkees.

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May 26, 2020
TWiV 617: Coronavirus Times
02:32:20

Daniel Griffin provides a clinical update on COVID-19, then we review TETRIS by Paterson NJ, modeling the effects of intervention in the US on cases and deaths, mixing PCR and serology data, and much more, including listener email.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker

Guest: Daniel Griffin

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Intro music is by Ronald Jenkees.

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May 24, 2020
TWiV 616: Singing about coronavirus
01:43:12

Vincent, Kathy and Rich discuss COVID-19 research paper overload, Moderna's mRNA vaccine Phase I results, increase of ACE2 RNA by cigarette smoke, and answer listener questions.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

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Intro music is by Ronald Jenkees.

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May 21, 2020
TWiV 615: Peter Daszak of EcoHealth Alliance
35:53

Vincent speaks with Peter Daszak, President of EcoHealth Alliance, a global nonprofit organization dedicated to protecting wildlife and public health from the emergence of disease.

Hosts: Vincent Racaniello

Guests: Peter Daszak

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Intro music is by Ronald Jenkees.

20% off The Invisible ABCs for TWiV listeners! Use promo code: ABC20 at checkout.

Send your virology questions and comments to twiv@microbe.tv

May 19, 2020
TWiV 614: COVID Tetris - Test, trace, isolate
02:47:27

Daniel Griffin provides a clinical update on COVID-19, then we review results showing requirement for the furin site in the SARS-CoV-2 spike for replication, US state vaccine exemptions, concerns with a rapid diagnostic test, and answers to listener questions.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker

Guest: Daniel Griffin

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Intro music is by Ronald Jenkees.

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May 17, 2020
TWiV 613: Jenner, vaccines, and COVID-19
01:45:37

Vincent, Kathy and Rich explain the Jenner Institute's SARS-CoV-2 vaccine, the NIH decision to stop the Remdesivir study, and answer listener questions.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

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Intro music is by Ronald Jenkees.

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May 14, 2020
TWiV 612: CEPI, preventing the next pandemic
36:28

From the Nipah Virus International Conference in Singapore, Vincent speaks with Richard Hatchett, CEO of CEPI, about its mission to stimulate and accelerate the development of vaccines against emerging infectious diseases.

Hosts: Vincent Racaniello

Guests: Richard Hatchett and Linfa Wang

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Intro music is by Ronald Jenkees.

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May 12, 2020
TWiV 611: Corona and crowns
02:25:19

Daniel Griffin provides a weekly clinical update on COVID-19, then Michael Schmidt discusses how dentistry can be safely practiced during a pandemic, followed by answers to listener questions.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guests: Daniel Griffin and Michael Schmidt

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Intro music is by Ronald Jenkees.

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May 10, 2020
TWiV 610: Coronavirus FAQ
01:38:53

The TWiV team summarizes serology-based tests for SARS-CoV-2, lack of effect of ACE inhibitors or ARBs on COVID-19 severity, and answers listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Intro music is by Ronald Jenkees.

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May 07, 2020
TWiV 609: A coronavirus chronology with Susan Weiss
01:14:41

Susan Weiss recalls some of her 40 years of research on coronaviruses, including mouse hepatitis virus, MERS-CoV, and now SARS-CoV-2.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Susan Weiss

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Intro music is by Ronald Jenkees.

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May 03, 2020
TWiV 608: Daniel Griffin's COVID-19 clinical report
57:12

Daniel Griffin updates the clinical situation with COVID-19 patients, followed by analysis of the remedesivir clinical trial results, and answers listener questions.

Hosts: Vincent Racaniello and Rich Condit

Guest: Daniel Griffin

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Intro music is by Ronald Jenkees.

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May 01, 2020
TWiV 607: Coronavirus epidemiology with Jeff Shaman
01:07:52

Jeff Shaman returns to TWiV to explain why more SARS-CoV-2 testing and contact tracing is needed to stop the pandemic, and provide insights on immunity and reinfection from seasonal CoVs, the problems with antibody tests, and what to expect in the coming months.

Hosts: Vincent Racaniello and Rich Condit

Guest: Jeff Shaman

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Intro music is by Ronald Jenkees.

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Apr 29, 2020
TWiV 606: Evidence-based science and medicine for COVID-19
01:54:03

Daniel Griffin provides his weekly update on the COVID-19 clinical situation, followed by our discussion of tests of an inactivated vaccine, results of serological surveys, an inhibitor of the cell protease needed for virus entry, and answers to listener questions.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Daniel Griffin

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Intro music is by Ronald Jenkees.

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Apr 26, 2020
TWiV 605: READDI for the next pandemic
52:49

Ralph Baric, Mark Heise and Nat Moorman discuss their non-profit initiative READDI, Rapidly Emerging Antiviral Drug Discovery Initiative, to start making drugs now for the next pandemic virus.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guests: Ralph Baric, Mark Heise, and Nat Moorman

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Intro music is by Ronald Jenkees.

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Apr 23, 2020
TWiV 604: Oral poliovaccine to prevent SARS-CoV-2 infection
01:04:21

Kostya Chumakov discusses the hypothesis that oral poliovirus vaccine can provide non-specific protection against many other viruses, and might prevent infection with SARS-CoV-2.

Host: Vincent Racaniello

Guest: Kostya Chumakov

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  • Nonpathogenic enteroviruses to prevent human disease (pdf)
  • OPV for COVID-19 (pdf)
  • Enteroviruses to prevent human infections (pdf)
  • Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Apr 21, 2020
TWiV 603: Cloudy with a chance of coronavirus
01:56:19

Daniel Griffin provides his weekly update on the COVID-19 clinical situation, followed by results of seroprevalence studies, analysis of CpG dinucleotide frequencies in the SARS-CoV-2 genome, and answers to listener questions.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Daniel Griffin

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Intro music is by Ronald Jenkees.

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Apr 19, 2020
TWiV 602: Coronavirus immunology with Stanley Perlman
01:14:01

Stanley Perlman joins TWiV to discuss immune responses to coronaviruses, including seasonal CoV, MERS, SARS, and SARS-CoV-2, including prospects for a vaccine.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Stanley Perlman

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Intro music is by Ronald Jenkees.

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Apr 16, 2020
TWiV 601: Das coronavirus with Christian Drosten
55:55

Coronavirus expert Christian Drosten joins Vincent to provide a view from Germany on COVID-19 and SARS-CoV-2.

Host: Vincent Racaniello

Guest: Christian Drosten

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Intro music is by Ronald Jenkees.

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Apr 14, 2020
TWiV 600: SARS-CoV-2 - enter the Coronials
01:53:23

Daniel Griffin joins TWiV to update on the clinical situation, then we discuss a 32 nucleotide deletion in ths SARS-CoV-2 genome, a scenario for emergence of the virus from a bat, followed by answers to listener email.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Daniel Griffin

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Intro music is by Ronald Jenkees.

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Apr 12, 2020
TWiV 599: Coronavirus update - we need a plan
02:08:09

Doris Cully joins TWiV to discuss inhibition of SARS-CoV-2 in cell culture by ivermectin, followed by continuing analysis of the coronavirus pandemic caused by SARS-CoV-2 including COVID-19 in Nadia the tiger, and prediction of respiratory failure by levels of IL-6.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

Guest: Doris Cully

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Intro music is by Ronald Jenkees.

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Apr 08, 2020
TWiV 598: Who was that masked man? Coronavirus update with Daniel Griffin
01:54:57

Daniel Griffin MD returns to TWiV from a hospital parking lot to provide updates on COVID-19 diagnostics, clinical picture, and therapeutics, followed by our coverage of the coronavirus pandemic caused by SARS-CoV-2.

Hosts: Vincent Racaniello, Dickson Despommier,Rich Condit, and Kathy Spindler

Guest: Daniel Griffin, MD

Download TWiV 598 (70 MB .mp3, 115 min)
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Intro music is by Ronald Jenkees.

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Apr 05, 2020
TWiV 597: A lot of immunology and some COVID-19 with Jon Yewdell
01:54:49

Immunologist Jon Yewdell joins Vincent and Rich to discuss immune responses in the context of infection with SARS-CoV-2.

Hosts: Vincent Racaniello and Rich Condit

Guest: Jon Yewdell

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Intro music is by Ronald Jenkees.

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Apr 03, 2020
TWiV 596: COVID-19 - an ounce of prevention
02:01:13

TWiV covers trials of hydroxychloroquine and convalescent plasma therapy for COVID-19, and answers listener questions on blood tests for antibodies, cross-protection among coronaviruses, acquiring infection from food or the gas pump, face masks containing copper, and much more.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

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Intro music is by Ronald Jenkees.

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Apr 02, 2020
TWiV 595: Coronavirus update - Daniel Griffin MD in the parking lot
01:57:25

Daniel Griffin MD joins TWiV from a hospital parking lot to provide updates on COVID-19 diagnostics, clinical picture, and therapeutics, and then the TWiV team continues coverage of the coronavirus pandemic caused by SARS-CoV-2.

Hosts: Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Daniel Griffin, MD

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Intro music is by Ronald Jenkees.

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Mar 29, 2020
TWiV Special: Conversation with a COVID-19 patient, Ian Lipkin
01:09:07

Ian Lipkin joins Vincent to talk about his experience as a COVID-19 patient, and issues surrounding the disease and SARS-CoV-2 including limiting transmission, antivirals, vaccines, and much more.

Hosts: Vincent Racaniello

Guest: W. Ian Lipkin

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Intro music is by Ronald Jenkees.

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Mar 28, 2020
TWiV Special: Coronavirus update with Mark Denison, MD
52:53

Pediatric infectious disease physician and coronavirologist Mark Denison joins Vincent for a discussion of COVID-19 and SARS-CoV-2 with an emphasis on antiviral therapeutics.

Hosts: Vincent Racaniello

Guest: Mark Denison

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Intro music is by Ronald Jenkees.

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Mar 26, 2020
TWiV 594: Coronavirus update - Shelter in place
01:52:25

A TWiV foursome provides an update on the SARS-CoV-2 pandemic, including antibody testing kits, FDA emergency approval of convalescent sera, and answer listener questions about the dangers of mail delivery and take out foods, decontamination of PPE, diagnostic testing, and much more.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

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Intro music is by Ronald Jenkees.

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Mar 25, 2020
TWiV 593: Coronavirus update - flatten the curve
02:19:17

Daniel Griffin joins Ori and the TWiV team an update on the SARS-CoV-2 pandemic, including gastrointestinal illness associated with infection, use of hydroxychloroquine and other antivirals, his experiences treating many patients in the New York area, and much more.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

Guests: Daniel Griffin, Ori Lieberman, and Valeria Cagno

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Intro music is by Ronald Jenkees.

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Mar 22, 2020
TWiV 592: Coronavirus update - dangerous curve ahead
01:53:39

Ori joins TWiV for an update on the SARS-CoV-2 pandemic, including scary modeling, clinical trials for antivirals and vaccines, asymptomatic transmission, and much more inspired by listener email.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Guest: Ori Lieberman

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Intro music is by Ronald Jenkees.

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Mar 19, 2020
TWiV Special: SARS-CoV-2 epidemiology with Stephen Morse
01:00:31

Epidemiologist Stephen Morse joins Vincent to discuss epidemiology of SARS-CoV-2 and preparedness for the COVID-19 pandemic.

Hosts: Vincent Racaniello

Guest: Stephen Morse

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Intro music is by Ronald Jenkees.

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Mar 18, 2020
TWiV Special: A medical student perspective on COVID-19
48:33

Ori Lieberman joins Vincent to discuss COVID-19, the disease caused by SARS-CoV-2, gleaned from his experience during clinical rotations in medical school.

Hosts: Vincent Racaniello

Guest: Ori Lieberman

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Intro music is by Ronald Jenkees.

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Mar 17, 2020
TWiV 591: Coronavirus update with Ralph Baric
02:03:21

Ralph Baric joins TWiV to dissect the coronavirus pandemic caused by SARS-CoV-2, including discussion on community spread, asymptomatic infections, origin of the virus, transmission, vaccine development, and much more.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Ralph Baric

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Intro music is by Ronald Jenkees.

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Mar 15, 2020
TWiV 590: COVID-19 and coronavirus - we have mail
02:06:35

The TWiV trio continues in-depth coverage of COVID-19 and SARS-CoV-2, including discussion on genome mutation and circulating lineages, handwashing, facemasks, cruise ship outbreaks, the South Korean situation, and much more.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

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Intro music is by Ronald Jenkees.

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Mar 08, 2020
TWiV Special: Coronavirus SARS-CoV-2 and COVID-19 update
57:41

Infectious disease physician Daniel Griffin and virologist Valeria Cagno join Vincent to provide updates on the situation with SARS-CoV-2 and COVID-19 in New York and Italy.

Host: Vincent Racaniello

Guests: Daniel Griffin and Valeria Cagno

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Intro music is by Ronald Jenkees.

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Mar 05, 2020
TWiV 589: Coronavirus update - it could be bad
01:23:45

Vincent and Rich update the current situation with COVID-19 and SARS-CoV-19, including fatality ratios, virus spreading outside of China, immunity to infection, vaccines, antivirals and much more.

Hosts: Vincent Racaniello and Rich Condit

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Intro music is by Ronald Jenkees.

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Mar 01, 2020
TWiV 588: Coronavirus update - Save the pangolin!
02:30:41

The TWiV team returns this week to SARS-CoV-2019 coverage to review the latest epi curves, the fatality rate, furin cleavage site and receptor binding domain in the spike glycoprotein, related CoV recovered from pangolins, evidence that the virus did not escape from a laboratory, and many more questions sent in by listeners.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

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Weekly Science Picks

Kathy - The deep sea
Rich - World's oldest message in a bottle
Dickson - Coronavirus: A visual guide
Vincent - Recent NSABB meeting Videocasts Day 1 Day 2

Listener Picks

Stephen - This podcast will kill you
Neva - China's surveillance
Sophia - WHO online courses

Intro music is by Ronald Jenkees.

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Feb 23, 2020
TWiV 587: One bite is all it takes
02:05:53

Vincent and Rich return to the University of Texas Medical Branch at Galveston to speak with Dennis Bente, Shannan Rossi, Nikos Vasilakis, and Scott Weaver about their work on viruses transmitted by mosquitoes and ticks.

Hosts: Vincent Racaniello and Rich Condit

Guests: Dennis Bente, Shannan Rossi, Nikos Vasilakis, and Scott Weaver

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Intro music is by Ronald Jenkees.

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Feb 16, 2020
TWiV 586: Coronavirus update: wash your hands
01:58:59

In this week's coverage of the coronavirus epidemic, the TWiV team discusses the fatality rate, China's initial reaction to the outbreak, conspiracy theories, how long the virus remains infectious on surfaces, and evidence for virus in the intestinal tract.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne

Download TWiV 586 (72 MB .mp3, 119 min)
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Weekly Science Picks

Brianne - Mutation, Adaptation, and Virus Genomes
Alan - The Comet
Rich - Finding Your Roots: Science Pioneers
Dickson - Let’s Fill Our Cities With Taller, Wooden Buildings
Vincent - Twenty-first century plague by Thomas Abraham

Listener Pick

Mark - Tracking CoV infections
Sophia - Legislative approaches to immunization

Intro music is by Ronald Jenkees.

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Feb 09, 2020
TWiV 585: The coronavirus epidemic
01:57:48

The TWiVerers continue their coverage of the new coronavirus outbreak in China, as the number of cases increase dramatically and the virus begins person-to-person transmission in other countries.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker


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Weekly Science Picks

Brianne - Pandemic
Alan - Educated by Tara Westover
Rich - Star Trek: Picard
Dickson - Highest Resolution Image Ever Taken of Surface of the Sun
Kathy - Scientists make vampire bats ‘glow’ to simulate vaccine spread
Vincent - Virology Lectures 2020

Listener Pick

Edward - Virus snowflake designs
Anthony - Microbe Hunting Autism to Zika

Intro music is by Ronald Jenkees.

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Feb 02, 2020
TWiV 584: Year of the coronavirus
01:46:21

Coronavirus expert Ralph Baric joins TWiV to explain the virology and epidemiology of the recent zoonotic outbreak spreading across China and overseas.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove,Rich Condit, Kathy Spindler

Guest: Ralph Baric

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Weekly Science Picks

Alan - Library plug-in for Firefox or Chrome
Rich - Sounds of the Solar Wind (Parker Solar Probe)
Dickson - Stunning wildlife photos
Kathy - Incomplete list of things that blow the minds of intro bio students
Vincent - Mosquito photographs by Alex Wild (and anti-pick)

Listener Pick

Justin - YadaYadaYada virus

Intro music is by Ronald Jenkees.

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Jan 26, 2020
TWiV 583: Galveston virus hunters
01:24:04

Vincent and Rich travel to Galveston National Laboratory to speak with Jim LeDuc, Tom Ksiazek, and Bob Tesch about their long careers as virus hunters.

Hosts: Vincent Racaniello and Rich Condit

Guests: Jim LeDuc, Tom Ksiazek, and Bob Tesh

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Intro music is by Ronald Jenkees.

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Jan 19, 2020
TWiV 582: This little virus went to market
01:58:06

TWiV provides updates on the new coronavirus causing respiratory disease in China, the current influenza season, and the epidemic of African swine fever, including determination of the three-dimensional structure of the virus particle.

Download TWiV 582 (71 MB .mp3, 118 min)
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Weekly Science Picks

Rich - Mayo Clinic - Ken Burns; Patient Care and Health Information
Dickson - Australia Fires; Insect ecology; Smoke and aerosols
Kathy - runcible
Vincent - Without a Vaccine, These Are Your Odds

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Jan 12, 2020
TWiV 581: Alimentary particles
01:31:11

For the first TWiV of 2020 we reveal that microbiome depletion with antibiotics alters the immune response to influenza vaccine, and how successive blood meals facilitate virus dissemination in mosquitoes and transmission potential.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker

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Weekly Science Picks

Brianne - Retrovirus cookie cutter! (and Phage, Adenovirus, Rabies virus, and Antibody
Alan - “Yah! Yah! Yah!” by Jack London, and the true story it’s based on
Dickson - Why whales are big but not bigger
Kathy - Dual Axis Illusion
Vincent - The Fall of the Faculty  by Benjamin Ginsberg

Listener Pick

Suellen - Patient Zero podcast

Intro music is by Ronald Jenkees.

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Jan 05, 2020
TWiV 580: Noncoding RNA with Chris Sullivan
01:36:27

From the University of Texas at Austin, Vincent and Rich speak with Chris Sullivan about his work on miRNAs encoded in the genomes of polyomaviruses and papillomaviruses, and how an RNA triphosphatase restricts hepatitis C virus replication.

Hosts: Vincent Racaniello and Rich Condit

Guest: Chris Sullivan

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Intro music is by Ronald Jenkees.

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Dec 29, 2019
TWiV 579: Reno viral
01:41:07

Vincent speaks with virologists at the University of Nevada at Reno about their careers and their work on herpesviruses, arboviruses, and the development of diagnostics for infectious diseases.

Host: Vincent Racaniello

Guests: Dave AuCoin, Cyprian Rossetto, Claudia Rückert, and Subhash Verma

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Intro music is by Ronald Jenkees.

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Dec 22, 2019
TWiV 578: Prometheus project
01:30:49

Vincent speaks with members of Prometheus, a team of academic and industrial scientists assembled to develop antibody-based therapeutics against infections caused by tick-borne Crimean-Congo hemorrhagic fever virus and rodent-borne hantaviruses, for which no approved vaccines or specific drugs are available.

Host: Vincent Racaniello

Guests: Kartik Chandran, Zachary Bornholdt, Steven Bradfute, John Dye, Matthias Forsell, Jason McLellan, Laura Walker, and Cecelia Vial.

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Intro music is by Ronald Jenkees.

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Dec 15, 2019
TWiV 577: Virologie structurale with Félix Rey
01:15:15

Vincent speaks with Félix Rey about his career and his work on solving structures of a variety of viruses and the insights learned about viral membrane fusion and antibody-mediated neutralization.

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Intro music is by Ronald Jenkees.

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Dec 08, 2019
TWiV 576: Big data in virology and public health
54:33

From the 22nd meeting of the European Society for Clinical Virology in Copenhagen, Vincent speaks with Thea, Heli, Kim, Caroline and Irma about big data and its increasing use in virology diagnostics, epidemiology, and public health.

Host: Vincent Racaniello

Guests: Thea Kølsen Fischer, Kim Benschop, Caroline Brown, Heli Harvala, and Irma Salimovic-Besic

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Intro music is by Ronald Jenkees.

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Dec 01, 2019
TWiV 575: Endless giant virus forms most beautiful
02:00:31

From the Fourth Symposium on Giant Virus Biology in Germany, Vincent, Rich, and Nels speak with Assaf, Stephen, and Alexandra about their careers and their work on giant viruses that infect ocean hosts: Emiliana huxleyi, Aureococcus anophagefferans, and a choanoflagellate.

Hosts: Vincent Racaniello, Rich Condit, and Nels Elde

Guests: Assaf Vardi, Stephen Wilhelm, and Alexandra Worden

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Intro music is by Ronald Jenkees.

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Nov 24, 2019
TWiV 574: How economics shapes science
01:11:25

From Georgia State, Vincent speaks with economics professor Paula Stephan about the ways science is supported in the US, how universities offload risks, the absence of risk-taking, and much more.

Hosts: Vincent Racaniello

Guest: Paula Stephan

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Intro music is by Ronald Jenkees.

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Nov 17, 2019
TWiV 573: Inventing viruses
01:53:19

William Summers joins the TWiV team to discuss some virology history, including the ever-changing concept of 'virus' and the contribution of phage research to the study of animal viruses.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

Guest: William Summers

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Weekly Science Picks

Alan - Restoration of Western Flyer
Rich - Purification of phage T7 RNA polymerase
Dickson - The Galaxy is Not Flat
Bill - Efficacy of tetravalent dengue vaccine
Vincent - Blowout by Rachel Maddow

Intro music is by Ronald Jenkees.

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Nov 10, 2019
TWiV 572: Your EV-D68th nervous breakdown
02:01:11

Amy joins the TWiV team to review evidence that enterovirus D68 is an etiologic agent of childhood paralysis, and her finding that the ability of the virus to infect cells of the nervous system is not a recently acquired property.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

Guest: Amy Rosenfeld

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Weekly Science Picks

Amy - Enterovirus biology and pathogenesis and Acute Flaccid Myelitis Association
Rich - Tesla
Dickson - Nikon Small World 2019 Photo Competition
Kathy - Term limits in academic leadership #1 and #2
Vincent - Coywolf: New hybrid carnivore

Listener Picks

Anonymous - Spill the Beans vaccinated shirts

Intro music is by Ronald Jenkees.

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Nov 03, 2019
TWiV 571: Piwi koalas
01:45:23

The League of Extraordinary Virologists celebrate the eradication of wild poliovirus type 3, and consider the effectiveness of an influenza vaccine produced in insect cells, and how small RNAs are protecting the Koala germline from retroviral invasion.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker

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Weekly Science Picks

Brianne - The Machinery of Life by David Goodsell
Alan - Pomological watercolors
Dickson - Wildlife Photographer of the Year
Kathy - DiversifyMicrobiology  DiversifyImmunology and Marmot becomes fox food
Vincent - Burnet A Life by Christopher Sexton

Listener Picks

Justin - Worm with three sexes

Intro music is by Ronald Jenkees.

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Oct 27, 2019
TWiV 570: Aarhus viral
01:41:23

At Aarhus University in Denmark, Vincent speaks with Trine Mogensen, Søren Paludan, Ole Søgaard, and Madalina Carter-Timofte about their careers and their work on sensing herpesviral DNA, immunodeficiencies that predispose to severe viral infections, and the path to a cure for HIV/AIDS.

Hosts: Vincent Racaniello

Guests: Trine Mogensen, Søren Paludan, Ole Søgaard, and Madalina Carter-Timofte

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Oct 20, 2019
TWiV 569: Smolt'in iron
01:50:19

The TWiV pro-vaxxers reveal viruses that infect endangered wild salmon, and how iron in host serum modulates dengue virus acquisition by mosquitoes.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker

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Weekly Science Picks

Brianne - Retraction of new CCR5/lifespan study
Alan - Nomad Press illustrated science books, and illustrator Lex Cornell
Dickson - RARE: Creatures of the Photo Ark
Vincent - The Odyssey of Eradication by Thomas Abraham

Listener Picks

Justin - Mass spec pen
Mark - What really brought down the Boeing 737 Max?

Intro music is by Ronald Jenkees.

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Oct 13, 2019
TWiV 568: Karolinska viral
01:35:22
 In the second episode from the Karolinska Institute in Stockholm, Vincent speaks with Jan Albert, Petter Brodin, and Anna Smed-Sörensen about their work on enterovirus D68, systems immunology, and human pulmonary viral infection and inflammation.

Hosts: Vincent Racaniello

Guests: Jan Albert, Petter Brodin, and Anna Smed-Sörensen

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Intro music is by Ronald Jenkees.

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Oct 06, 2019
TWiV 567: Outbreaks and a breakout
01:51:42

The TWiV team covers outbreaks of eastern equine encephalitis virus in the US and poliovirus in the Philippines, and explain how a chemokine induced by HIV-1 infection helps release more virus particles from cells.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Science Picks

Brianne - History of infectious disease before/after vaccines
Alan - NIH Ham Radio Club
Rich - Renewable jet fuel from air
Dickson - Newly Discovered Comet Is Likely Interstellar Visitor
Kathy - How professors spend their time
Vincent - Non-polio enterovirus surveillance network

Listener Picks

Alexey - Periodic Table Podcasts and Videos

Intro music is by Ronald Jenkees.

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Sep 29, 2019
TWiV 566: Chicken gumbo and a corona
01:50:45

The TWiV team reveals the protein corona that surrounds virus particles and influences infectivity and amyloid aggregation, and a proofreading-impaired herpesvirus that produces quasispecies-like populations.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Guest: Kiki Warren

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Weekly Science Picks

Alan - Astronomy photographer of the year
Rich- Urban living leads to high cholesterol... in crows
Kiki- Reversal of epigenetic aging
Vincent- General Virology by SE Luria

Listener Picks

Sindhu - Sweden Solar System
Anthony- Surprising role of viruses in evolution with Eugene Koonin
Paul- The Obscure Virus Club

Intro music is by Ronald Jenkees.

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Sep 22, 2019
TWiV 565: Karolinska virology
01:25:49

From the Karolinska Institute in Stockholm, Vincent speaks with Niklas Björkström, Ali Mirazimi, and Matti Sällberg about their work on the impact of chronic hepatitis C virus infection on NK cells, Crimean-Congo hemorrhagic fever virus vaccines, and immunotherapy to block entry of hepatitis B and D viruses.

Hosts: Vincent Racaniello

Guests: Niklas Björkström, Ali Mirazimi, and Matti Sällberg

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Sep 15, 2019
TWiV 564: Virology Nobel Prizes with Erling Norrby
01:14:11

From the 16th Smögen Summer Symposium on Virology, Vincent speaks with Erling Norrby about how he has used archival material to provide insight into early Nobel Prizes for research on viruses.

Hosts: Vincent Racaniello

Guest: Erling Norrby

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Intro music is by Ronald Jenkees.

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Sep 08, 2019
TWiV Special: Call me David Tuller
01:12:35

David Tuller returns to talk about his efforts of the past year to expose the methodological and ethical problems with the PACE and Lightning trials for therapy of ME/CFS.

Host: Vincent Racaniello

Guest: David Tuller

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Intro music is by Ronald Jenkees.

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Sep 03, 2019
TWiV 563: BLT on mice
01:30:49

The TWiVologists consider whether to receive an influenza vaccine in August (in the northern hemisphere), and mice implanted with human lung fragments for studying microbial pathogens.

Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker

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Weekly Science Picks

Brianne - Why we need to increase diversity in the immunology research community
Alan - Stock photos of vaccination that don’t suck
Kathy- Sample size calculator
Vincent- How Economics Shapes Science by Paula Stephan

Listener Picks

Melinda - Zome Tools

Intro music is by Ronald Jenkees.

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Sep 01, 2019
TWiV 562: Take a breath
02:06:55

TWiV travels to Rutgers University to speak with Brad, Kay, Siobain, and Kim about their careers and their work on viruses of plants, fungi, bacteria, diatoms, and coccolithophores.

Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker

Guests: Brad Hillman, Kay Bidle, Siobain Duffy, and Kim Thamatrakoln

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Aug 25, 2019
TWiV 561: Hot or not
01:33:27

The Autonomous CollecTWiVe reveal two effective treatments for Ebolavirus infection, how a virus in a fungus confers heat tolerance to a plant, and dampened inflammation as a mechanism for bat tolerance to viral infection.

Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker

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Weekly Science Picks

Brianne - Deaf student makes sign language terms to communicate science
Alan - Show Your Stripes
Vincent- Sixty Years of Discovery

Listener Picks

Eric - This drug could end HIV - why hasn't it?

Intro music is by Ronald Jenkees.

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Aug 18, 2019
TWiV 560: CEIRS, influenza and company
01:01:27

From the meeting of the Centers of Excellence for Influenza Research and Surveillance, Vincent speaks with Alan, Florian and Jennifer about their careers, the purpose of CEIRS, universal influenza vaccines, and cellular responses to infection in pediatric populations.

Host: Vincent Racaniello

Guests: Alan Embry, Florian Krammer, and Jennifer Nayak

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Aug 11, 2019
TWiV 559: Nectin connection what's your infection?
01:47:49

The complete TWiV team give a report on the Ebola virus outbreak in DRC, and reveal that cell surface nectin proteins cause the transfer of cytoplasmic cargo, including measles virus, between cells.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich ConditKathy Spindler, and Brianne Barker

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Brianne - DukeMed Distinguished Award: Bill Joklik
Alan - Audubon photography awards for 2019
Rich - Joklik paper on vaccinia virus mRNA; Joklik MEM
Dickson- Ghost orchid pollination revealed
Kathy- Crocheted petri plates
Vincent- Documents relating to history of ASV

Listener Picks

Neva - What happens if we engineer a superbug?

Intro music is by Ronald Jenkees.

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Aug 04, 2019
TWiV 558: Joklik's legacy
01:01:11

From ASV 2019 at the University of Minnesota, TWiV explores the origins of the American Society for Virology with Sid Grossberg and Pat Spear.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guests: Sid Grossberg and Pat Spear

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Intro music is by Ronald Jenkees.

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Jul 28, 2019
TWiV 557: Congress in Rotterdam
01:06:52

From the European Congress of Virology in Rotterdam, Vincent and local co-host Ben Berkhout speak with Ron Fouchier, Rosina Girones, and Marie-Paule Kieny about their careers and their work on influenza virus, environmental virology, and developing an Ebola virus vaccine during an epidemic.

Hosts: Vincent Racanielloand Ben Berkhout

Guests: Ron Fouchier, Rosina Girones, and Marie-Paule Kieny

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Intro music is by Ronald Jenkees.

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Jul 21, 2019
TWiV 556: Glycolyl's not for the birds
01:42:59

TWiV minus one reveals delayed neurological deficits in children without microcephaly born to Zika virus infected mothers, and N-glycolyl-neuraminic acid as a receptor for influenza A viruses.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker

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Weekly Science Picks

Brianne - Foldable viral capsid models and Foldable models demonstrate T numbers
Alan - Laws Guide to Nature Drawing and Journaling
Dickson- NASA 50th Events
Kathy- Alta Obscura’s 17,069 strange and wonderful places
Vincent- TWiEVO 44: The enemy of my enemy is my phage

Listener Picks

Anthony - Global Water Pathogen Project

Intro music is by Ronald Jenkees.

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Jul 14, 2019
TWiV 555: Fidelity and the single cell
01:16:13

From ASM Microbe 2019, Vincent, Brianne and Calvin meet up with Craig Cameron to discuss his career and his work exploring RNA-dependent RNA synthesis and single cell virology.

Hosts: Vincent Racaniello, Brianne Barker, and Calvin Yeager

Guest: Craig Cameron

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Intro music is by Ronald Jenkees.

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Jul 07, 2019
TWiV 554: Full fathom five thy viromes lie
01:18:51

A trio TWiVers reports on influenza in Australia, how a host protein impacts bird to human movement of influenza virus, and marine DNA viral diversity in the oceans from pole to pole.

Hosts: Vincent Racaniello, Kathy Spindler, and Alan Dove

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Weekly Science Picks

Alan - Stephanie Langel’s Discovery Talk
Kathy- Map of languages in the USA
Vincent- Grad student mental health with Susanna Harris video and on TWiM 199

Listener Picks

Fernando - Pushing back on hyped-up science

Intro music is by Ronald Jenkees.

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Jun 30, 2019
TWiV 553: Polio with David Oshinsky
01:05:36

Vincent speaks with David Oshinsky, the Pulitzer Prize-winning author of Polio: An American Story, about the history of poliovirus vaccines.

Host: Vincent Racaniello

Guest: David Oshinsky

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Intro music is by Ronald Jenkees.

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Jun 23, 2019
TWiV 552: Delta and the amazing technicolor dreamcoat
01:56:01

Team TWiV reveals DNA polymerases that do not require a primer, and packaging of hepatitis delta virus by the envelope glycoproteins of diverse viruses.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Kiki Warren

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Weekly Science Picks

Alan - Seek
Rich - Want to See My Genes? Get a Warrant and NIH director will no longer speak on all-male science panels
Brianne- Unique scientists
Dickson- Vaccines - Calling the Shots
Vincent- NY eliminates religious vaccine exemptions and Jessica Biel reveals that she does not understand vaccines
Kiki- Converting type A to type O blood

Listener Picks

Justin - An Apple a Day

Intro music is by Ronald Jenkees.

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Jun 16, 2019
TWiV 551: Golden hands
01:00:07

At Retroviruses 2019 in Cold Spring Harbor, Vincent speaks with virologist Bryan Cullen about his work and his career, together with former associates Ann Skalka, Paul Bieniasz, and Michael Malim.

Host: Vincent Racaniello

Guests: Bryan Cullen, Paul Bieniasz, Michael Malim, and Ann Skalka

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Intro music is by Ronald Jenkees.

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Jun 09, 2019
TWiV 550: Covering up the shiny parts
01:45:07

TWiV explains the use of a neuronal cell line to study herpes simplex virus latency and reactivation, and a strategy for creating vaccines that induce antibodies against specific epitopes.

Hosts: Vincent Racaniello, Dickson Despommier,Alan Dove, Rich Condit, and Brianne Barker

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Weekly Science Picks

Alan - Quabbin Reservoir
Rich - Katherine Swan Ginsburg Humanism in Medicine Program; The Arnold P. Gold Foundation
Brianne- UPitt Measles Simulator
Dickson- James Webb Space Telescope
Vincent- Nobel Prizes and Life Sciences by Erling Norrby

Intro music is by Ronald Jenkees.

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Jun 02, 2019
TWiV 549: The church of protocadherin
01:43:05

Kartik and Rohit join the TWiV team to present their identification of protocadherin-1 as a cell receptor for New World hantaviruses.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Guests: Kartik Chandran and Rohit Jangra

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This episode is sponsored by the 2019 Chem/Bio Defense Science and Technology Conference. Are you working on innovative research that can shape the future of chemical or biological defense? Submit your abstract and present your work to more than 1,500 leaders from government, academia and industry. Visit www.cbdstconference.comfor more details.

Weekly Science Picks

Alan - Temi and Trint
Rich - Using Jupiter's moons to determine where on Earth you are
Kathy- Best architecture in every state
Vincent - Cyberwire Podcast: The Ghost and the Mole
Kartik- Slack
Rohit- Antibody responses to viral infections

Intro music is by Ronald Jenkees.

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May 26, 2019
TWiV 548: Mice, shrews, and caterpillars
01:11:35

Vincent travels to the European Congress of Virology in Rotterdam and with local co-host Marion Koopmans speak with Martin Beer, Stephan Gunther, and Vera Ross about their careers and their work on Lassa virus, Borna virus, and insect viruses.

Hosts: Vincent Racanielloand Marion Koopmans

Guests: Martin Beer, Stephan Gunther, and Vera Ros

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This episode is sponsored by the 2019 Chem/Bio Defense Science and Technology Conference. Are you working on innovative research that can shape the future of chemical or biological defense? Submit your abstract and present your work to more than 1,500 leaders from government, academia and industry. Visit www.cbdstconference.com for more details.

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

May 19, 2019
TWiV 547: Upstate virology
01:35:37

Vincent travels to the University at Albany to speak with Cara, Rachel, and Alex about their careers and their work on stress granules, epitranscriptomics, and arboviruses.

Host: Vincent Racaniello

Guests: Cara Pager, Rachel Netzband, and Alex Ciota

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This episode is sponsored by the 2019 Chem/Bio Defense Science and Technology Conference. Are you working on innovative research that can shape the future of chemical or biological defense? Submit your abstract and present your work to more than 1,500 leaders from government, academia and industry. Visit www.cbdstconference.comfor more details.

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

May 12, 2019
TWiV 546: Delta blues and chitlins
02:02:25

The un-encapsidated TWiV Humans discuss finding hepatitis D virus-related sequences in birds and snakes, and fatal swine acute diarrhoea syndrome caused by a coronavirus of bat origin.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

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Links for this episode

This episode is sponsored by the 2019 Chem/Bio Defense Science and Technology Conference. Are you working on innovative research that can shape the future of chemical or biological defense? Submit your abstract and present your work to more than 1,500 leaders from government, academia and industry. Visit www.cbdstconference.com for more details.

Weekly Science Picks

Alan - Plots of Data visualization tool
Rich - How to control the brain; Meet UF Physician Kelly Foote, MD
Dickson- Oceanix
Kathy- Iceproofing large structures
Vincent - Neanderthal Man: In Search of Lost Genomes by Svante Paabo

Listener Pick

Johyne- NYTimes Mag Lab (sorry, no link)
Sheena - History of Vaccines by NPR

Intro music is by Ronald Jenkees.

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May 05, 2019
TWiV 545: Biocrimes and misdemeanors
01:44:17

Jens Kuhn returns to TWiV to explain Select Agents, Priority Pathogens, Australia List Pathogens, Risk Group Agents, biosafety, biosecurity, and biosurety.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker

Guest: Jens Kuhn


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Weekly Science Picks

Jens - Forvo pronunciation guide
Brianne -How long do vaccines last?
Alan- How much hotter is your home town than when you were born?
Dickson- 50 Stunning Photos of Earth
Vincent - Madness and Memory by Stanley Prusiner

Intro music is by Ronald Jenkees.

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Apr 28, 2019
TWiV 544: Immunogaga
01:47:30

The TWiV team reveals the repertoire of anti-viral antibodies in newborn humans, and a complement protein that binds the adenovirus capsid and prevents release of the viral DNA.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Science Picks

Brianne - Doctors use HIV in gene therapy to fix 'bubble boy' disease
Rich - I Want What My Male Colleague Has
Kathy- Preventing airborne disease (video and primary article)
Vincent - The Mueller Report

Listener Pick

Steve- Vaccine Mythbusting
Cyprian- Ten simple rules towards healthier research labs

Intro music is by Ronald Jenkees.

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Apr 21, 2019
TWiV 543: Stoned and senile
01:48:10

The TWiV team discusses Medusavirus, isolated from a hot spring in Japan, and induction of neurodegeneration by recurrent herpes simplex virus 1 infection of mice.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Science Picks

Brianne - How to Take a Picture of a Black Hole
Alan- Jupiter Marbleimage
Rich - NASA Commercial Crew Program; How SpaceX and Boeing will get Astronauts to the ISS; Everyday Astronaut
Dickson- Sky-High Stunners
Kathy- Arts at Michigan photo winnersand UM Microscopy Core image contest winners
Vincent - NYC declares emergency over measles outbreak, mandates vaccinations and EMDataResource

Listener Pick

Martin- Sydney Brenner passes

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Apr 14, 2019
TWiV 542: Inside Microbiotix
01:05:01

Vincent travels to Microbiotix, Inc, a biopharmaceutical company in Worcester, MA to speak with four members of the company about their discovery and development of small molecule drugs that target serious infectious diseases.

Host: Vincent Racaniello

Guests: Terry Bowlin, Zach Aron, Grace Lui, and Islam Hussein

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Listener Pick

Islam- How to successfully collaborate with industry

Intro music is by Ronald Jenkees.

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Apr 07, 2019
TWiV 541: Cloaking devices
01:28:47

The TWiVers present mitoviruses, which infect mitochondria, and how quasi-enveloped hepatitis A virus gets naked again.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

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Weekly Science Picks

Alan- Where and when to see cherry blossoms
Dickson- Nebraska floods
Kathy- Peeps fungal infection experiment
Vincent - Emergency declared in NY over measles, unvaccinated barred from public spaces

Listener Pick

Sam- STLR conversations
Josh- Tree of Life

Intro music is by Ronald Jenkees.

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Mar 31, 2019
TWiV 540: Wascally wiruses
01:48:47

The TWiVstars reveal the diversity of herpes simplex virus type 2 in a neonatal population, and parallel adaptation of rabbits in three countries to myxoma virus.

Hosts: Vincent Racaniello, Dickson Despommier, Rich ConditAlan Dove, and Kathy Spindler

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Weekly Science Picks

Alan- The Quarters
Rich- Brian May - New Horizons (Ultima Thule Mix) [Official Music Video]
Dickson- How rats became an inescapable part of city living
Kathy- Principal Component Analysis (short longer) and Educational Material about Influenza Viruses
Vincent - Why “chickenpox parties” are a terrible idea—in case it’s not obvious

Intro music is by Ronald Jenkees.

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Mar 24, 2019
TWiV 539: Multitudes contain me
01:41:47

The TWiV hosts present two potentially seminal papers, on long-distance chemoattraction of a host by a chlorovirus, and replication of a nanovirus across multiple cells in a plant.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker

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Weekly Science Picks

Brianne - Why Do So Many Scientists Want to be Filmmakers
Alan- Better boarding method airlines won’t use
Dickson- Mass timber building
Kathy- What organisms to study flow chart
Vincent - World Pulls Andon Cord on 737 MAX

Listener Pick

RichardThe Real Cost of Knowledge
Islam- 200 icosahedral viruses poster
Mike- Post-Doc Me Now

Intro music is by Ronald Jenkees.

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Mar 17, 2019
TWiV 538: An Iowa caucus of viruses
01:01:35

TWiV travels to the University of Iowa to speak with Wendy Maury and Stanley Perlman about their research on Ebolavirus entry and coronavirus pathogenesis.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guests: Wendy Mauryand Stanley Perlman

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Intro music is by Ronald Jenkees.

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Mar 10, 2019
TWiV 537: Boundary issues
01:43:51

The Scholars of the Podcast reveal ribosomal proteins encoded in viral genomes, and a protein cell receptor for bat influenza viruses.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Science Picks

Brianne - Yes, I'm a Scientist on Twitter. Stop Judging Me.
Alan- Impact of vaccines, graphed in heat maps
Dickson- Treehoppers
Kathy- World watershed maps
RichGene Machine by Venki Ramakrishnan
Vincent - House hearing on measles outbreak (ASM comment)

Listener Pick

Jordan- Facebook may remove anti-vaccine recommendations

Intro music is by Ronald Jenkees.

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Mar 03, 2019
TWiV 536: A flock of seagulls, a herd of seals
01:28:20

Vincent and Alan travel to Tufts Veterinary School where they meet up with members of the Runstadler lab to talk about their work on influenza virus circulation in water birds and seals.

Hosts: Vincent Racaniello and Alan Dove

Guests: Jonathan Runstadler, Nichola Hill, Wendy Puryear, and Kate Sawatzki

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Intro music is by Ronald Jenkees.

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Feb 24, 2019
TWiV 535: Miles to go before I leak
01:36:11

The TWiV team discuss the use of quantum dots to study uncoating of influenza virus in real time, and induction of endothelial dysfunction by flavivirus NS1 proteins in a tissue-specific manner.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

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Weekly Science Picks

Brianne - Hotel Influenza
Alan- Your town’s climate in 60 years
Dickson- BMC Research in Progress Photo Competition
RichNASA's Opportunity Rover Mission on Mars Ends (landing animation)
Vincent - Watch a single cell become a complex organism in six minutes

Listener Pick

Anne- Pathogenesis II Kickstarter

Intro music is by Ronald Jenkees.

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Feb 17, 2019
TWiV 534: Portal to the METTL
01:34:45

The TWiV crew reveal a unique portal on the calcivirus capsid formed upon receptor engagement, and the regulation of interferon responses in virus-infected cells by methylation of mRNA.

Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker

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Weekly Science Picks

Brianne - The Red Queen's Race Card Game
Alan- Pentax Papilio II
Dickson- Felice Frankel on improving visual side of science
KathyHistory of the alphabet chart (free download) usefulcharts.com (see blog, such as Latin Greek Cyrillic Venn Diagram)
Vincent - Virology Lectures 2019

Listener Pick

Peter- Microbehunter (YouTube, blog, forum)

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Feb 10, 2019
TWiV 533: Recurring threads
01:51:59

The TWiVosophers review the Chinese plasma virome revealed by non-invasive prenatal testing, and a new filovirus genome from bats in China.

Hosts: Vincent Racaniello, Rich ConditKathy Spindler, and Brianne Barker

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Weekly Science Picks

Brianne - Trying Polar Vortex Experiments at Home
Rich- Three Identical Strangers
Kathy- Science wear, especially for Valentine’s Day (discount)
Vincent - State of anti-vaccine movement in US and Top 10 Health Threats for 2019

Listener Pick

Amy- If government can't deliver safe vaccines, is it fit to rule?
Ted- Understanding Economics of Microbial Threats (pdf)

Intro music is by Ronald Jenkees.

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Feb 03, 2019
TWiV 532: Morbillivirus had a little lamb
01:38:53

The TWiVers discuss the spread of African swine fever virus and its threat to pig farming, and the zoonotic potential of peste des petits ruminants virus.

Hosts: Vincent RacanielloAlan Dove, Rich Condit, and Kathy Spindler

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Weekly Science Picks

Alan - Retraction Watch database
Rich- “The Mayo Clinic: Faith Hope Science” by Ken Burns
KathyU-M EEB Photographer at Large contest
Vincent - Vaccines: An achievement of civilization

Listener Pick

David- Useless Knowledge Begets New Horizons

Intro music is by Ronald Jenkees.

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Jan 27, 2019
TWiV 531: Circ du RNA
01:47:13

Patrick Moore returns to TWiV to discuss the discovery from the Chang-Moore laboratory of circular RNAs in cells infected with herpesviruses.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, and Kathy Spindler

Guest: Patrick Moore

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Weekly Science Picks

Brianne – The herd to the rescue
Alan – Magic Wings Butterfly Conservatory
Dickson 100,000 Genomes Project
Kathy – Your Age on Other Worlds
Vincent – Vitamin D and Prevention of Cancer and Cardiovascular Disease
Pat North Korea and Bioweapons

Listener Pick

EricThe Molecular Basis of Life

Intro music is by Ronald Jenkees.

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Jan 20, 2019
TWiV 530: Quiet please!
01:42:49

Steve Goff returns to TWiV to discuss the work of his laboratory on how retroviral genomes are silenced in infected cells.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, and Kathy Spindler

Guest: Steve Goff

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🎼 They’ll histone you when you start to transcribe,
And they’ll histone you just for tryin’ to get by,
So be careful when you uncoat your genome,
‘Cause everybody must histone.

Links for this episode

Weekly Science Picks

Alan - The Tangled Tree by David Quammen
Dickson- Ammonia could power the globe
KathyPortmanteaux and A.Word.A.Day
Vincent - Curioscity
Steve- Alice and Bob Meet the Wall of Fire

Listener Pick

Chaim- Tony Fauci on getting your flu vaccine (mp3)

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Jan 13, 2019
TWiV 529: Rueckert Road
01:15:53

At the University of Wisconsin-Madison, Vincent meets up with one of his virology heroes, Roland R. Rueckert, to talk about his research and his second career as a forest manager.

Host: Vincent Racaniello

Guest: Roland R. Rueckert

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Intro music is by Ronald Jenkees.

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Jan 08, 2019
TWiV 528: Our annual recapsidation
02:07:55

In the first episode for 2019, the TWiV team reviews the amazing virology stories of the past year.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, Rich Condit, and Kathy Spindler

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Weekly Science Picks

Alan - Pandemic Trail game
Rich- On a Bat’s Wing and a Prayer
Dickson- Decoding Watson
Kathy- Phenotypic variation in outbred and inbred mice
Vincent - Trump County Confronts the Administration Amid Rash of Child Cancers

Listener Pick

Anne- Peter Hotez interview
Islam- Letter from Crick to Watson (pdf)

Intro music is by Ronald Jenkees.

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Jan 06, 2019
TWiV 527: City mouse, country mouse
01:26:41

The TWiV team summarizes the discovery of Sin Nombre virus, and presents evidence that neurotropic flaviviruses can cause intestinal dysmotility syndromes after systemic infection of mice.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, Rich Condit, and Kathy Spindler

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Weekly Science Picks

Alan - Zooming into Sagittarius A, ESO video
Rich- Orbits and Ice Ages: A History of Climate
Dickson- National Geographic Best Photos 2018
KathyHealthMap Vaccine Finder
Vincent - Taylor Custom

Listener Pick

Neal- The Yoda of Silicon Valley

Intro music is by Ronald Jenkees.

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Dec 30, 2018
TWiV 526: In the beginning there was pol
01:44:19

The TWiV hosts discuss the distribution of prions in the eyes of patients with sporadic Creutzfeldt-Jacob disease, and the origins and evolution of RNA viruses.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler

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Weekly Science Picks

Alan - Population mountains to visualize cities
Rich- A Neanderthal Perspective on Human Origins with Svante Pääbo
KathyNASA Space Mission posters
Vincent - Package Thief vs Glitter Bomb Trap

Listener Pick

Neal- Was a Scientist Jailed?

Intro music is by Ronald Jenkees.

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Dec 23, 2018
TWiV Special: Vaccines Did Not Cause Rachel's Autism
19:01

Vaccine scientist, pediatrician, and autism dad Peter Hotez talks about his new book, Vaccines Did Not Cause Rachel's Autism.

Host: Vincent Racaniello

Guest: Peter Hotez

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Intro music is by Ronald Jenkees.

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Dec 19, 2018
TWiV 525: The A Bee Cs of bee viruses
01:38:43

Michelle Flenniken joins TWiV to talk about honeybees and the work of her laboratory on honeybee viruses.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Michelle Flenniken

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Weekly Science Picks

Michelle - First 21 days of a bee's life; NPR's Hidden Brain; Varroa destructor triggers deformed wing virus in bees
Brianne -
Flu Near You
Alan
 - Skype a Scientist program
Rich- NASA's Voyager 2 Probe Enters Interstellar Space
KathyWhich ones are bees? And What it feels like to be a bee
Vincent - Fecal sequencing and Vaccines did not cause Rachel's autism by Peter Hotez

Intro music is by Ronald Jenkees.

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Dec 16, 2018
TWiV 524: Slicing and dicing with Raul
01:16:13

Raul Andino joins Vincent and Amy to talk about the finding that a cricket paralysis virus protein restricts RNA-based immunity in insects by regulating the activity and stability of the Argonaute protein.

Hosts: Vincent Racaniello and Amy Rosenfeld

Guest: Raul Andino

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Weekly Science Picks

Amy - Insectropolis
VincentGenome-edited baby

Intro music is by Ronald Jenkees.

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Dec 12, 2018
TWiV 523: Virology in Zürich
01:17:28

At the University of Zürich, Vincent speaks with virologists Cornel Fraefel, Urs Greber, and Silke Stertz about their careers and their work on AAV2, adenovirus entry, and influenza virus.

Hosts: Vincent Racaniello

Guests: Cornel Fraefel, Urs Greber, and Silke Stertz

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Intro music is by Ronald Jenkees.

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Dec 09, 2018
TWiV 522: Readers of the lost ORF
01:47:17

The TWiVsters review isolation of a naturally occurring DNA virus from fruit flies, and the cell-type specific function of a small transmembrane protein encoded in an open reading frame upstream of the enterovirus polyprotein.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

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Weekly Science Picks

Alan - $40 internationally standard cup of tea
Rich- Mars InSight Mission
Dickson- New York Botanical Garden Train Show
KathyComedy wildlife photo awards finalists
Vincent - Senator Gillibrand calls for funding AFM research and our Crowdsourcing of EV-D68 research

Listener Pick

Fernando - Pathfinders by Felipe Fernández-Armesto; Erebus by Michael Palin

Intro music is by Ronald Jenkees.

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Dec 02, 2018
TWiV 521: Spitting in the Allee
01:54:12

Team TWiV cover the discovery of another giant virus from 30,000 year old Siberian permafrost, and how viral aggregation accelerates the production of new infectious viruses and increases fitness, demonstrating an Allee effect.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit,  Kathy Spindler, and Brianne Barker

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Weekly Science Picks

Brianne - Why don't we have vaccines against everything?
RichGolden Globe Race
Dickson- The Anatomy of Figure Drawingby Robert Demarest and Warder Clyde Allee
KathyOrientation of the moon’s appearance, Southern Hemisphere
Vincent - Paul has Measles in English and Spanish

Intro music is by Ronald Jenkees.

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Nov 25, 2018
TWiV 520: This old mouse
01:55:49

The TWiVidae review universal influenza vaccines that are in clinical trials, and discovery of an atypical parvovirus that causes chronic kidney disease in middle aged, immunocompromised laboratory mice.

Hosts: Vincent Racaniello, Dickson Despommier, Alan DoveRich Condit,  Kathy Spindler, and Brianne Barker

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Weekly Science Picks 1:17:24

Brianne - Nebula Genomics: a new start-up offering free genome sequencing (with a catch)
Alan- GRE scores are poor predictorof degree completion
RichThe Science Mill(video)
Dickson- The 12 cranial nerves (mnemonic)
KathyNAS report on Sexual Harassment of Women (free pdf) Iceberg figure
Vincent - The Tangled Tree by David Quammen and TWiEVO #37

Listener Pick

Mark- Weekly US Map: Influenza Summary

Intro music is by Ronald Jenkees.

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Nov 18, 2018
TWiV 519: Fishing for viruses in senile
01:35:57

The TWiVomers review a potential role for herpes simplex virus type 1 as a cause of Alzheimer's Disease, including the finding that amyloid-beta acts as an antiviral by enveloping virus particles.

Hosts: Vincent Racaniello, Dickson Despommier, Alan DoveRich Condit, and Brianne Barker

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Weekly Science Picks

Brianne - Pandemic (board game)
AlanThe Shortwave Radio Audio Archive (siteand blog)
RichJames Cook's First Pacific Voyage, 1768-1771 (interactive map)
Dickson- The Scientist on Instagram
Vincent - State of the World’s Fungi

Listener Pick

David- Bruno LaTour

Intro music is by Ronald Jenkees.

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Nov 11, 2018
TWiV 518: Hershey's viruses
01:26:23

Vincent travels to Penn State College of Medicine in Hershey, PA to speak with Nick and Leslie about their careers and their work on human cytomegalovirus and retroviruses.

Host: Vincent Racaniello

Guests: Nicholas Buchkovich and Leslie Parent

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Intro music is by Ronald Jenkees.

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Nov 04, 2018
TWiV 517: Just in time for Halloween
01:19:01

Brianne and Vincent tackle two studies that utilize infectious viruses to examine zoonotic potential of Bombali virus, a new ebolavirus from an insectivorous species in Sierra Leone, and a human mumps-like virus from an African flying fox in DRC.

Hosts: Vincent Racaniello and Brianne Barker

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Weekly Science Picks

Brianne - Ed Yong on AFM
Vincent - Goggles Optional podcast (especially #243)

Intro music is by Ronald Jenkees.

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Oct 28, 2018
TWiV 516: HUSH little virus, don't you transcribe
02:00:46

Lonya and Jeremy take the TWiV team beTWIXt primate immunodeficiency virus proteins Vpx and Vpr and how they counteract transcriptional repression of proviruses by the HUSH complex.

Hosts: Vincent Racaniello, Dickson DespommierRich ConditKathy Spindler, and Brianne Barker

Guests: Leonid Yorkovetskiy and Jeremy Luban

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Weekly Science Picks

Brianne - The Chimp and the River by David Quammen
RichJames Cook’s First Voyage Journal (20 sec Google Earth summary)
Kathy- High resolution Antarctica map NYTimes 46MB Maps (more info and 43 tb maps)
Dickson- Jellyfish
Jeremy - Pictorial Guide to Living Primates; All The World's Primates
LonyaChougui et al. HIV-2/SIV Vpx counters HUSH
Vincent - Research!America

Intro music is by Ronald Jenkees.

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Oct 21, 2018
TWiV 515: When virus is in retrograde
01:38:51

The TWiV team notes the passing of Tom Steitz, an outbreak of acute flaccid myelitis in the US, a continuing Ebola virus outbreak in DRC, respiratory vaccinia due to inhalation of ground up rabbit skin, and how a human papillomavirus capsid protein directs virus-containing endosomes towards the nucleus.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker

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Weekly Science Picks

Brianne - Germ City-Microbes and the Metropolis Museum Exhibition
Alan
- Nikon 2018 Small World in Motion competition
Kathy- Ion Torrent Sequencing (video)
Dickson- 2018 Nobel Prizes Economics
KathyOcean-centric map
Vincent - Intelligence Matters Podcast: Anthony Fauci on threats from epidemics

Listener Picks

Gonsalo - Cells at Work (Manga, Anime)

Intro music is by Ronald Jenkees.

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Oct 14, 2018
TWiV 514: Staying below the ADAR
01:48:29

The TWiVumvirate reviews this years crop of Nobel Prizes, and how cells prevent leakage of mitochondrial double-stranded RNA into the cytoplasm, which would otherwise lead to the production of interferon.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

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Weekly Science Picks 1:28:33

Alan- Compound Interest chemistry graphics
Kathy- Writing letters of recommendation Guidelines Trix & Psenka Schmader et al. Madera et al.
Dickson- Japan Fireworks
Vincent - The Game of T-Cells and Apple Park Lego

Listener Picks

Steve - Shomu's Biology

Intro music is by Ronald Jenkees.

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Oct 07, 2018
TWiV 513: Double-stranded in Belgium
01:02:05

From the 13th International Symposium on dsRNA viruses in Belgium, Vincent speaks with Harry Greenberg about his career and his work on rotaviruses, noroviruses, hepatitis B virus, and influenza virus.

Host: Vincent Racaniello

Guest: Harry Greenberg

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Intro music is by Ronald Jenkees.

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Sep 30, 2018
TWiV 512: Flexuous SUMO wrestlers
01:42:49

Anne Simon joins the TWiV team to talk about plant viruses, including plum pox virus that devastates nut and stone fruit trees, and a geminivirus protein that regulates viral DNA synthesis.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich ConditBrianne Barker, and Anne Simon

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Weekly Science Picks

Brianne -  Why are so many genes unstudied? (Zimmerand Yong)
Alan - Unveiling the RNA World
Rich - Spaghetti mystery solved (PNAS paper)
Dickson - Science Fair
Vincent - A PhD Lab Coat Ceremony

Listener Picks

Stephen - Flu vaccine myth rant by Crislip
Jolene - Research Matters in PLoS Path and PLoS Biology
Nicholas - Charity Matters app

Intro music is by Ronald Jenkees.

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Sep 23, 2018
TWiV 511: Accessory found guilty in DC
01:48:55

Ned Landau joins the TWiV team to discuss restriction of HIV replication by SAMHD1, and a viral antagonist that can be used to produce a dendritic cell vaccine.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Ned Landau

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Weekly Science Picks

Brianne- Online Immunology Course
Alan- Bacteria Builder
Rich2018 Ig Nobel Prizes
Dickson- Between Fear and Hope
Ned - HUSH silencing of transposons
Vincent - Paywall publishing ban (Schlitz statement); Curry on DORA

Listener Pick

Steve- Paywall: Business of Scholarship and Biohazard
Islam- Peer review Twitter post

Intro music is by Ronald Jenkees.

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Sep 16, 2018
TWiV 510: Retroviruses at Cold Spring Harbor
01:04:13

Vincent and Dickson travel to the 44th Retrovirus meeting at Cold Spring Harbor Laboratories, where they speak with John Coffin, Stephen Hughes, Ya-Chi Ho, and Matt Takata about the meeting and their work on HIV-1.

Hosts: Vincent Racaniello and Dickson Despommier

Guests: John Coffin, Stephen Hughes, Ya-Chi Ho, and Matt Takata

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Intro music is by Ronald Jenkees.

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Sep 09, 2018
TWiV 509: 41,103 bases under the sea
01:46:27

The TWiV team considers whether those who can do, can't teach, and newly discovered viruses of planarians and Aplysia with the largest RNA genomes.

Hosts: Vincent Racaniello, Dickson Despommier, Alan DoveKathy Spindler and Brianne Barker

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Weekly Science Picks

BrianneClimate change visualization
AlanAnova sous vide cooker
Dickson- Fire season in western US
Kathy- Sunscreen in UV and The Projector Illusion
Vincent - The Usefulness of Useless Knowledge

Listener Pick

River- The Conscience of the Present

Intro music is by Ronald Jenkees.

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Sep 02, 2018
TWiV 508: Bioweapon
02:07:39

Jens returns to present a brief history of bioweapons, with a focus on the program in the Soviet Union, the largest ever undertaken, and his experience working in the decommissioned Soviet bioweapons laboratory known as Vector.

Hosts: Vincent Racaniello, Dickson DespommierRich Condit, and Kathy Spindler

Guest: Jens Kuhn

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Weekly Science Picks

Jens - Nudibranchs, Beastly Garden, large nidovirus (one, two)
Rich - 
Living inside a canister
Dickson -
Global rivers and streams
Kathy - TWiM 181 Dr. Warhol’s Periodic Table of Microbes
Vincent - Twitter Bots and Russian Trolls Amplify Vaccine Debate

Intro music is by Ronald Jenkees.

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Aug 26, 2018
TWiV 507: The fusion of form and function
01:58:33

The TWiV team discuss the biology of Ebola viruses, and how localization of the membrane proteins of vaccinia virus drive function: the fusion machinery sits at the tips of virions, and binding proteins are at the sides.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Science Picks

Alan - Puzzled Escape Games
Rich - 
An Extremely Detailed Map of the 2016 Election
Dickson -
Parker Solar Probe
Kathy - Ancient earth globe and connected Dinosaur database
Brianne
 - STEMM education should get HACD
Vincent - Free tuition for all NYU medical students

Listener Pick

Heather- GoFarm blog

Intro music is by Ronald Jenkees.

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Aug 19, 2018
TWiV Special: David Tuller is PACEman
01:08:37

David Tuller returns to provide an update of his investigative work to expose the methodological and ethical problems with the PACE trial for ME/CFS.

Host: Vincent Racaniello

Guest: David Tuller

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Intro music is by Ronald Jenkees.

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Aug 17, 2018
TWiV 506: A Cafeteria full of jelly rolls
01:37:29

The TWiVniks explain how the three-dimensional structure of the giant Cafeteria roenbergensis virus suggests a new mode of assembly, and the apparent elimination of dengue fever in an Australian city by release of mosquitoes harboring Wolbachia.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, and Brianne Barker

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Weekly Science Picks

Alan - Ebola research begins at the NEIDL
Dickson -
Science Photo Library
Brianne
 - First liquid water (underground lake) found on Mars
Vincent - Thirty years ago, we could have saved the planet

Listener Pick

Edmund- STEM talk

Intro music is by Ronald Jenkees.

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Aug 12, 2018
TWiV 505: Rosebola
02:02:11

The TWiV hosts review persistence of Ebola virus after the end of the Liberian outbreak, and the potential role of two herpesviruses in the pathogenesis of Alzheimer's disease.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, Rich Condit, Kathy Spindler and Brianne Barker

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Weekly Science Picks

Alan - Impossible Burger
Rich - 
SpaceX Just Sent Algae to the ISS, Here's How It'll Power Deep Space Missions
Dickson -
Art and Science Intersection (Art Science Museum)
Brianne
 - Why it is not a 'failure' to leave academia
Kathy2003 video history of nuclear explosions 1945 - 1998
Vincent - Revisionist History Episode 8 and Episode 9

Listener Pick

Mark- TWIV bingo (png)

Intro music is by Ronald Jenkees.

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Aug 05, 2018
TWiV 504: Flying foxes and barking pigs
01:50:31

The TWiVerinos discuss Nipah virus and the recent outbreak in India, and the first cast of polio in Papua New Guinea in 18 years.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, Rich Condit, and Brianne Barker

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Weekly Science Picks

Alan - Glaciers of the Rockies aerial photos
Rich - 
SpaceX CRS-15 mission to the space station(wiki)
Dickson -
Test of Einstein's theory of relativity
Brianne
 - biorender
Vincent - True or False? with Michael Schmidt

Listener Pick

Jolene- Dogs cannot get autism

Intro music is by Ronald Jenkees.

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Jul 29, 2018
TWiV 503: The greening of TWiV
01:01:33

Vincent, Rich and Kathy travel to ASV 2018 at the University of Maryland to speak with Svetlana Folimonova and Anne Simon about their work on viruses that infect plants.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guests: Svetlana Folimonova and Anne Simon

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Intro music is by Ronald Jenkees.

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Jul 22, 2018
TWiV 502: Texas road phage
01:31:53

The TWiV team travels to Texas A&M University, home of the Center for Phage Technology, where they speak with Ry Young and Jason Gill about their work on viruses that infect bacteria.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Guests: Jason Gill and Ry Young

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Intro music is by Ronald Jenkees.

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Jul 13, 2018
TWiV 501: Outbreak
01:29:37

Vincent visits the Smithsonian Institution and speaks with Sabrina Sholts, Jon Epstein, and Ed Niles about the exhibit Outbreak: Epidemics in a Connected World.

Host: Vincent Racaniello

Guests: Sabrina Sholts, Jon Epstein, and Ed Niles

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Intro music is by Ronald Jenkees.

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Jul 08, 2018
TWiV 500: Keep virology weird
02:00:11

The entire TWiV team visits The University of Texas in Austin to record episode #500 with guests Jinny Suh, Jason McClellan, and Jon Huibregtse.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, Rich Condit, and Kathy Spindler

Guests: Jinny Suh, Jason McClellan, and Jon Huibregtse

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Weekly Science Picks

Alan - The Airplane Cabin Microbiome
Rich - 
Coalition for Epidemic Preparedness Innovations (CEPI)(wiki)
Dickson -
The Big Five Mass Extinctions
Kathy
 - Virus scarves at Red Bubble phage-specific     variety
Vincent - Science podcasts

Listener Pick

Maureen- 12 year old takes on Flint's Water Crisis

Intro music is by Ronald Jenkees.

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Jul 01, 2018
TWiV 499: Good virologists go to Halifax
58:15

Vincent and Alan travel to the Canadian Society for Virology meeting in Halifax, Nova Scotia to speak with Nathalie and Craig about their vision for the society, and with Kate and Ryan about their careers and their research.

Hosts: Vincent Racanielloand Alan Dove

Guests: Nathalie Grandvaux, Craig McCormick, Kate O'Brien, and Ryan Noyce

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Intro music is by Ronald Jenkees.

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Jun 24, 2018
TWiV 498: Salivating at ASM Microbe
01:08:29

Vincent, Kathy and Rich travel to ASM Microbe 2018 in Atlanta where they speak with Stacy Horner and Ken Stapleford about their careers and their research.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guests: Stacy Hornerand Ken Stapleford

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Intro music is by Ronald Jenkees.

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Jun 17, 2018
TWiV 497: Europic 2018
59:45

At Europic 2018, a meeting on picornaviruses in the Netherlands, Vincent speaks with Sasha Gorbalenya, Jim Hogle, Ann Palmenberg and Frank van Kuppeveld about their careers and their research.

Hosts: Vincent Racanielloand Rich Condit

Guests: Sasha Gorbalenya, Jim Hogle, Ann Palmenberg, and Frank van Kuppeveld

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Intro music is by Ronald Jenkees.

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Jun 10, 2018
TWiV 496: Vaccines work, whether or not you believe in them
01:15:53

Vincent and Rich recorded this episode at Vaccines in the 21st Century, a meeting held at the University of California, Irvine, where they spoke with Stacy Schultz-Cherry, Douglas Diekema, and Andrew Noymer about vaccine facts and fiction.

Hosts: Vincent Racanielloand Rich Condit

Guests: Stacey Schultz-Cherry, Douglas Diekema, and Andrew Noymer

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Intro music is by Ronald Jenkees.

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Jun 03, 2018
TWiV 495: Influenza virus keeps its ion channel 20
01:51:07

The TWiVerati follow up on the Ebola virus outbreak, virulence of Ebola-Makona, and reveal how a parasitoid is revealed to hyperparasitoids, and binding of influenza virus to a calcium ion channel to mediate influenza virus entry.

Hosts: Vincent RacanielloAlan Dove, and Kathy Spindler

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Weekly Science Picks

Alan - National Cryptologic Museum
Rich - 
Science is mostly about staring
Dickson -
New Zealand gloworms
Kathy
 - Openingof Smithsonian Outbreak; conference advice General ASV
Vincent - ICTV online

Intro music is by Ronald Jenkees.

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May 27, 2018
TWiV 494: Ebola Makona is the opposite of hakuna matata
01:12:35

Vincent, Kathy, and Alan review the ongoing outbreak of Ebola virus in the Democratic Republic of the Congo, and the finding that mutations identified in the 2015 West African epidemic do not alter pathogenesis in animals.

Hosts: Vincent RacanielloAlan Dove, and Kathy Spindler

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Weekly Science Picks

Alan - Happy 35th birthday, PCR
Kathy
- Everything can be a speaker
Vincent - Ocean rise due to rocks(debunked); Gates advises Trump on viruses

Listener Pick

Noah- David Baltimore on iBiology

Intro music is by Ronald Jenkees.

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May 20, 2018
TWiV 493: Condit is on drugs and norovirus is lit
01:39:51

The TWiVerati discuss the FDA Advisory Committee deliberation on the anti-poxvirus drug tecovirimat, and immune cells in gut-associated lymphoid tissue as the major target during acute murine norovirus infection.

Hosts: Vincent Racaniello, Dickson Despommier, Alan DoveRich Condit, and Kathy Spindler

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Weekly Science Picks

Alan - Personal Finance for PhDsby Emily Roberts
Kathy
- Optical illusions fool artificial intelligence
Rich- 2017-2018 snowfall graphic
Dickson- Dust from the Sahara
Vincent - The Last Days of Smallpoxby Mark Pallen

Listener Pick

Intro music is by Ronald Jenkees.

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May 13, 2018
TWiV 492: CRISPR diagnostics
01:49:29

The Masters of the TWiXome review the development of sensitive, portable, and field-based viral diagnostics using the CRISPR-Cas system.

Hosts: Vincent Racaniello, Dickson Despommier, Alan DoveRich Condit, and Kathy Spindler

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Weekly Science Picks

Alan - Decline of local newspapers leaves epidemiologists blind
Kathy
- Journal oversight, mental health research
Rich- The Big Sort: An Insider's Tour of a Recycling Plant
Dickson- When Science Meets Art
Vincent - A Crack in Creationby Doudna and Sternberg

Listener Pick

TomTrillions Upon Trillions of Viruses Fall From the Sky Each Day

Intro music is by Ronald Jenkees.

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May 06, 2018
TWiV 491: The Ileum and the Odyssey
01:37:07

The TWiVome deconstructs the evolutionary history of RNA viruses, and immune promortion of murine norovirus pathogenesis by replication in intestinal tuft cells.

Hosts: Vincent Racaniello, Dickson Despommier, Alan DoveRich Condit, and Kathy Spindler

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Weekly Science Picks

Alan - Oligodendroglioma in song
Kathy
- Everything-repellent coating to grime proof phone screens & more
Rich- Gaia star map
Dickson- Clouds are complicated
Vincent - Eradicating polio with a vaccine we must stop using

Listener Pick

StephenForget the Avengers, it took real heroes to make India polio-free

Intro music is by Ronald Jenkees.

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Apr 29, 2018
TWiV 490: Shave ice and giant viruses
01:36:51

From the TWiV team, human cowpox infection possibly acquired from a pet cat, and a new giant mimivirus of green algae with genes encoding enzymes of fermentation.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

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Weekly Science Picks

Kathy- Landscapes that look like another world (but they are from Spain)
Rich - Brighton Collaboration; Viral Vector Vaccines Safety Working Group (V3SWG)(Chen & DeStefano: Vaccine adverse events: causal or coincidental?)
Dickson
- Clouds of Jupiter and EBNA2 and autoimmunity
Vincent - More than one-third of graduate students report being depressed (original article)

Intro music is by Ronald Jenkees.

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Apr 22, 2018
TWiV 489: CD4 Hunter
01:06:11

 

Vincent visits Sandra Urdaneta-Hartmann at Drexel University College of Medicine in Philadelphia to talk about the development of the mobile video game 'CD4 Hunter'.

Host: Vincent Racaniello

Guest: Sandra Urdaneta-Hartmann

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Intro music is by Ronald Jenkees.

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Apr 15, 2018
TWiV 488: Who nose if it will work in humans
01:42:13

The TWiV team reveals that recent mumps virus outbreaks in the US are due to waning vaccine efficacy, and an intranasally delivered small interfering RNA that controls West Nile infection in the brain.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, and Kathy Spindler

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Weekly Science Picks

Kathy- Peak bloom and photographing cherry blossoms
Dickson- Origins of vertebrate RNA viruses
Alan- Rare footage of anglerfishin the deep ocean
Vincent - NIH must reduce disparities in funding

Listener Picks

Mariann - Eden Project and Bellyvision Apparatus and the Like
Amir- Winners of ICR Science Photography and Photography Contest

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Apr 08, 2018
TWiV 487: Milwaukee viral
01:03:07

At the Medical College of Wisconsin, Vincent talks with current and former members of the Department of Microbiology and Immunology about their work and their careers.

Host: Vincent Racaniello

Guests: Dominique Carter, Sid Grossberg, John Kirby, Scott Terhune, and Vera Terakanova

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Intro music by Ronald Jenkees

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Apr 01, 2018
TWiV 486: Sean Whelan on being haploid
01:03:25

Sean Whelan returns to TWiV to speak with Vincent about using haploid cell lines to identify genes encoding cell receptors for viruses, including Ebolavirus, Lassa virus, and more.

Host: Vincent Racaniello

Guest: Sean Whelan

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Intro music by Ronald Jenkees

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Mar 25, 2018
TWiV 485: Fishing with defective flies
01:25:51

The TWiV posse considers viral insulin-like peptides encoded in fish genomes, and insect antiviral immunity by production of viral DNA from defective genomes of RNA viruses.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, Kathy Spindler, and Brianne Barker

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Weekly Science Picks

Kathy - Vegas casinos lost money on physicists
Brianne - Astronaut twin's DNA is not 7% different!
Dickson - Parasitic Diseases lecture videos
Alan - In Season blog by Donna Long
Vincent - Buckyball viruses

Listener Picks

Paul - Wine labels (front, back)

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Mar 18, 2018
TWiV 484: Float like a mimivirus STING like a bat
01:26:53

The TWiVumvirate discuss the giant Tupanvirus, with the longest tail in the known virosphere, and dampened STING dependent interferon activation in bats.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, Kathy Spindler, and Brianne Barker

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Mar 11, 2018
TWiV 483: Every infection is unhappy in its own way
01:41:19

Vincent and the Virals review undermining of antiviral effectiveness by genital inflammation, and heterogeneity of influenza virus infection in single cells.

Hosts: Vincent RacanielloAlan Dove, and Kathy Spindler

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Weekly Science Picks

Kathy - Dance Dance
RichSnopes
Alan - Next Generation Science Standards
Vincent - TWiEVO 28: Genetics of skin pigmentation in Africa

Intro music is by Ronald Jenkees.

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Mar 04, 2018
TWiV 482: Don't EVEome without antibody expressed
01:37:45

The TWiV Masters discuss serologic evidence of Ebolavirus infection in a population with no outbreaks, and the set of endogenous viral elements in the mosquito genome.

Hosts: Vincent Racaniello, Dickson DespommierAlan DoveKathy Spindler, and Brianne Barker

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Feb 25, 2018
TWiV 481: And biles to go before I delete
01:42:15

The TWiVodrome considers the intestinal tract as an alternative infection route for MERS coronavirus, and how reduced accumulation of defective viral RNAs might lead to severe influenza.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, Rich Condit, and Kathy Spindler

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Feb 18, 2018
TWiV 480: The PFU in your achoo
01:53:41

Scott Hensley joins the TWiVites to review the current influenza season and presence of the virus in exhaled breath of symptomatic cases.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, Rich Condit, and Kathy Spindler

Guest: Scott Hensley

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Weekly Science Picks

Kathy - Flow Virometry
Rich - Falcon Heavy Launch links:  Flight diagram; Launch including booster landing; Tesla in space; Tesla orbit; Reusable booster failures; Booster size
Dickson - Next generation of weapons
Alan - Ed Yong’s story on fixing gender imbalance in science reporting
Vincent - CD4 Hunter iOS Android

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Feb 11, 2018
TWiV 479: Trypsin the flight fantastic
01:50:33

The TWiVome explores induction of antiviral responses by repeating patterns of capsids, and a fungus in the mosquito gut that aids dengue virus replication.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, Rich Condit, and Kathy Spindler

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Feb 04, 2018
TWiV 478: A pox on your horse
01:41:17

The TWiV team explains how infectious horsepox virus - likely the ancestor of smallpox vaccines - was recovered from chemically synthesized DNA fragments.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, Rich Condit, and Kathy Spindler

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Weekly Science Picks

Kathy - UM EEB photo contest
Rich - Dino-Lite digital microscope and digital microscope camera
Dickson - Sandford Photography
Alan - A list of female virologists
Vincent - Virology Lectures 2018

Listener Picks

Andrew - Interferome
Neva - The Untreatable by Gavin Francis

Intro music is by Ronald Jenkees.

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Jan 28, 2018
TWiV 477: Raiders of the lost Arc
01:43:21

The TWiVodrome explains how a gag-like protein from a retrotransposon forms virus-like particles that carry mRNA  within vesicles across the synapse.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, Rich Condit, and Kathy Spindler

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Jan 20, 2018
TWiV 476: In ACOD1 we trust
01:44:45

Nels joins the TWiV team to talk about his work on genomic accordions in vaccinia virus, hepatitis B virus in a 439 year old mummy, and viral induction of energy synthesis by a long noncoding RNA.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, Rich Condit, and Kathy Spindler

Guest: Nels Elde

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Jan 14, 2018
TWiV 475: Everything is viral
01:50:25

In the first episode for 2018, the TWiV team reviews the amazing virology stories of 2017.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, and Kathy Spindler

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Weekly Science Picks

Kathy - Voyager recording and book
RichDavid Sheldrick Wildlife Trust (Maktao)
Dickson - Global Croplands Map
Alan - The Great Influenza one day at a time
Vincent - The Doomsday Machine by Daniel Ellsberg

Listener Picks

Mark - Science Moms and Science of HIV
Andy - Ask Me Anything
Steve - Critical Attitude in Medicine

Intro music is by Ronald Jenkees.

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Jan 07, 2018
TWiV 474: Call me fish meal
01:43:01

The TWiVanguardians take on Bodo saltans virus, a leviathan which infects an abundant flagellated eukaryote in Earth's waters.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, and Kathy Spindler

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Weekly Science Picks

Kathy - Every second
Dickson - Top 10 Science Images 2017
Alan - Shortwave Radiogram
Vincent - Science March on Instagram

Listener Picks

Islam - Class Crossword (Armored Penguin)
Peter - The Last of the Iron Lungs

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Dec 31, 2017
TWiV 473: Assessing a risk and infecting you twice
01:49:57

The Fellowship of the Virus discuss enhancement of dengue disease in humans: the contribution of antibody concentration and increased binding to Fc receptors.

Hosts: Vincent Racaniello, Dickson DespommierAlan DoveRich Condit, and Kathy Spindler

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Weekly Science Picks

Kathy - Today in Science History
Dickson - 10 Breakthrough Technologies 2017
Rich - SpaceX to orbit a Tesla
Alan - Debt in America
Vincent - The Death of Expertise by Tom Nichols  (NYTimes review)

Listener Picks

Stephen - A Concise Paper
Johnye - Holiday song parodies (one, two, three)
Tom - SMBC: Are viruses alive?

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Dec 24, 2017
TWiV Special: Ray Ortega in the podcaster's studio
01:00:15

Vincent speaks with professional podcast producer Ray Ortega about his career and the power of the podcast.

Host: Vincent Racaniello

Guest: Ray Ortega

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Intro music is by Ronald Jenkees.

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Dec 20, 2017
TWiV 472: The riddle of the skinks
01:54:01

The TWiV team reveal the origin of the poxvirus membrane, and how a retrovirus drove the development of the placenta of a lizard.

Hosts: Vincent Racaniello, Dickson DespommierAlan DoveRich Condit, and Kathy Spindler

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Dec 17, 2017
TWiV 471: Songs of innocence and experience
01:48:23

The TWiVerinos discuss restriction of dengue virus vaccine by Sanofi, and data which suggest that Dengvaxia causes enhanced disease in previously uninfected recipients.

Hosts: Vincent Racaniello, Dickson DespommierAlan DoveRich Condit, and Kathy Spindler

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Weekly Science Picks

Kathy - NASA is reinventing the wheel
Dickson - Stunning neuroscience images
Rich - Moneyball by Michael Lewis (film)
Alan - Diverse Sources
Vincent - Zombie gene protects elephants from cancer (Quanta, TWiEVO)

Listener Picks

Scott - Why Vaccines Matter by Cynthia Gorney and The Song of the Dodo by David Quammen.

Intro music is by Ronald Jenkees.

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Dec 10, 2017
TWiV 470: Just a passing phage
01:56:57

The TWiV ninjas reveal that bacteriophage particles rapidly move across monolayers of eukaryotic cells from different tissues. 

Hosts: Vincent Racaniello, Dickson DespommierAlan DoveRich Condit, and Kathy Spindler

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This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe   delivery service in the country. Get $30 off your first delivery and FREE SHIPPING by going to blueapron.com/twiv.

Weekly Science Picks

KathyPhoto of 3200 year-old tree in one image
Dickson - Microsculpture
Rich - A Short History Of Humans And Germs
Alan - Planets app
Vincent - Laptops Are Great. But Not During a Lecture or a Meeting

Listener Picks

Basel - Joint Pathology Center
John - OpenStax

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Dec 03, 2017
TWiV 469: Mycovirus stuffed potatoes
01:48:01

The TWiV hosts discuss a plant virus that infects a fungus, and whether you need to work insane hours to succeed in science.

Hosts: Vincent Racaniello, Dickson DespommierAlan DoveRich Condit, and Kathy Spindler

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This episode is brought to you by the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. For more information about the Department, visit http://bit.ly/micromssm

This episode is brought to you by  the Virology and Gene Therapy PhD program at the Mayo Clinic Graduate School of Biomedical Sciences in Rochester, Minnesota. The renowned Mayo Clinic Virology and Gene Therapy program is currently accepting applications until December first. If you want to be trained in the exciting fields of oncolytic virotherapy, gene therapy, vaccine creation, or basic virology, visit mayoclinic.org to apply to the Virology and Gene Therapy program at the Mayo Clinic Graduate School of Biomedical Sciences.

Weekly Science Picks

Kathy - Patterns Video (WonderLab)
Dickson - Nikon 2017 Photomicrography Contest
Rich - Leonardo Da Vinci by Walter Isaacson
Alan - Sail Magazine Best Boats 2018
Vincent - Science Is Dry, Obscure, Complex?

Listener Picks

Ben - Is the staggeringly profitable business of scientific publishing bad for science?

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Nov 26, 2017
TWiV 468: Zika by the slice
01:46:59

Amy joins the TWiV team to talk about her career and her work on Zika virus neurotropism using embryonic mouse organotypic brain slice cultures.

Hosts: Vincent Racaniello, Dickson DespommierAlan DoveRich Condit, and Kathy Spindler

Guest: Amy Rosenfeld

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Links for this episode

This episode is brought to you by the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. For more information about the Department, visit http://bit.ly/micromssm

This episode is brought to you by  the Virology and Gene Therapy PhD program at the Mayo Clinic Graduate School of Biomedical Sciences in Rochester, Minnesota. The renowned Mayo Clinic Virology and Gene Therapy program is currently accepting applications until December first. If you want to be trained in the exciting fields of oncolytic virotherapy, gene therapy, vaccine creation, or basic virology, visit mayoclinic.org to apply to the Virology and Gene Therapy program at the Mayo Clinic Graduate School of Biomedical Sciences.

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Nov 19, 2017
TWiV 467: Jon and Ted's Excellent Adventure
01:39:55

Jon and Teddy Yewdell join the TWiV team to talk about their careers, their research, and the problems with biomedical research.

Hosts: Vincent RacanielloAlan Dove,and Rich Condit

Guest: Jon Yewdell and Teddy Yewdell

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Links for this episode

This episode is brought to you by the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. For more information about the Department, visit http://bit.ly/micromssm

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Nov 12, 2017
TWiV 466: The Capsid Club
01:05:31

From Indiana University, Vincent and Kathy speak with Tuli Mukhopadhyay, John Patton, and Adam Zlotnick about their careers and their work on alphaviruses, hepatitis B virus, and rotaviruses.

Host: Vincent Racaniello and Kathy Spindler

Guests: Tuli MukhopadhyayJohn Patton, and Adam Zlotnick

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Intro music is by Ronald Jenkees.

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Nov 05, 2017
TWiV 465: Theodora the explorer
01:50:01

Theodora Hatziioannou joins the TWiV team to discuss a macaque model for AIDS, and how a cell protein that blocks HIV-1 infection interacts with double-stranded RNA.

Hosts: Vincent Racaniello, Dickson Despommier, Alan DoveRich Condit, and Kathy Spindler

Guest: Theodora Hatziioannou

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This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. Get $30 off your first delivery and FREE SHIPPING by going to blueapron.com/twiv.

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Theodora - To Kill A Mockingbird by Harper Lee
Kathy
25 MILLION Orbeez in a pool
Dickson - Fluid Dynamics of Paint
Rich - The Hitchhiker's Guide to the Galaxy by Douglas Adams
Alan - 30 days at sea: timelapse
Vincent - TWiEVO 24 and Every Time Zone

Listener Picks

Fernando - Lego Women of NASA

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Oct 29, 2017
TWiV 464: Boston baked viruses
01:27:55

At Tufts University Dental School in Boston, Vincent speaks with Katya Heldwein and Sean Whelan about their careers and their work on herpesvirus structure and replication of vesicular stomatitis virus.

Host: Vincent Racaniello

Guests: Katya Heldwein and Sean Whelan

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Links for this episode

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Oct 22, 2017
TWiV 463: We haven't meth but these names ring Nobel
01:44:09

The TWiViridae review the 2017 Nobel Prizes for cryoEM and circadian rhythms, and discuss modulation of plant virus replication by RNA methylation.

Hosts: Vincent Racaniello, Dickson Despommier, Alan DoveRich Condit, and Kathy Spindler

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Links for this episode

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. Get $30 off your first delivery and FREE SHIPPING by going to blueapron.com/twiv.

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

KathyWhen biospheres collide
Dickson - Blame 10 rivers for ocean plastic
Alan - Farming in The Netherlands
Vincent - Meet the Microbiologist

Listener Picks

Jay - OmegaTau podcast
TrudyArrowsmith by Sinclair Lewis
Mark - iOS app Human Anatomy Atlas and Master in Business podcast

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Oct 15, 2017
TWiV Special: Tear it up with David Tuller
01:07:41

David Tuller returns to discuss his efforts to expose the methodological and ethical problems with the PACE trial for ME/CFS.

Hosts: Vincent Racaniello

Guest: David Tuller

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Intro music is by Ronald Jenkees.

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Oct 14, 2017
TWiV 462: Splicing RNA with Phillip A. Sharp
38:45

Vincent speaks with 1993 Nobel Laureate Phillip A. Sharp about his career and his seminal discovery of RNA splicing in mammalian cells, which changed our understanding of gene structure.

Hosts: Vincent Racaniello

Guest: Phillip A. Sharp

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Links for this episode

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Oct 07, 2017
TWiV 461: Gotta trace them all!
02:07:11

The TWiVers discuss the declining readability of scientific texts, and review the use of self-inactivating rabies virus for tracing neural circuits.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

Guest: Brianne Barker

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Links for this episode

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Kathy -Best eclipse video (to date) and solargraph
Dickson - Photos by Will Eades
Brianne - Pale Rider by Laura Spinney
Rich“Supergenes” Drive Evolution
Vincent -Anatomy of a Moral Panic

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Sep 30, 2017
TWiV 460: Penn, a great sandbox for science
01:32:53

Vincent travels to the University of Pennsylvania and speaks with virologists Gary Cohen, Scott Hensley, Carolina Lopez, and Susan Weiss about their careers and their research.

Host: Vincent Racaniello

Guests: Gary Cohen, Scott Hensley, Carolina Lopez, and Susan Weiss

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Links for this episode

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Sep 24, 2017
TWiV 459: Polio turns over a new leaf
01:44:35

The TWiV team reviews the first FDA approved gene therapy, accidental exposure to poliovirus type 2 in a manufacturing plant, and production of a candidate poliovirus vaccine in plants.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

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Links for this episode

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Kathy - Cassini photos
Dickson - Caliber Biotherapeutics
Alan - Grav
Rich - Google street view of the International Space Station (article)
Vincent - the bioinformatics chat

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Sep 17, 2017
TWiV 458: Saliva of the fittest
01:58:35

The TWiVians present an imported case of yellow fever in New York City, and explain how a dengue virus subgenomic RNA disrupts immunity in mosquito salivary glands to increase virus replication.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

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Links for this episode

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Kathy - Antibody validation Editorial Asilomar meeting report
Dickson - Despommierphotoart.com
Alan - NOAA Hurricane Hunters
Rich - Awakenings by Oliver Sacks (encephalitis lethargica)
Vincent - Goodnight Lab by Chris Ferrie

Listener Picks

Pete - Change Agent by Daniel Suarez
Paul
- Pasteur's Gambit by Stephen Dando-Collins
MaureenDiscovery Documentary First in Human

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Sep 09, 2017
TWiV 457: The Red Queen meets the White Rabbit
02:03:13

Brianne returns to the TWiV Gang to discuss the distribution of proteins on the influenza viral genome, and the evolution of myxoma virus that was released in Australia to control the rabbit population.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

Guest: Brianne Barker

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This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase - WITH FREE SHIPPING - by going to blueapron.com/twiv.

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Brianne - 3D printed viruses
Dickson - Secrets of Schooling
AlanMaking sails in the Nevada desert
Rich - David Vetter isolation suit (Wiki)
Vincent - Confounds the Science

Intro music is by Ronald Jenkees.

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Sep 03, 2017
TWiV 456: Be careful of canons
02:04:15

Brianne joins the TWiVMasters to explain how mutations in genes encoding RNA polymerase III predispose children to severe varicella, and detection of an RNA virus by a DNA sensor.

Hosts: Vincent Racaniello and Rich Condit

Guest: Brianne Barker

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Links for this episode

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Brianne - Up-Goer Five Challenge (related to Thing Explainer)
Rich - The Farthest: Voyager in Space and Vipassana Momma: Science
Vincent - Episode of Revisionist History: The Basement Tapes

Listener Pick

Jennie - What Piece of Lab Equipment Are You?

Intro music is by Ronald Jenkees.

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Aug 26, 2017
TWiV 455: Pork and genes
01:45:13

Erin joins the TWiVirions to discuss a computer exploit encoded in DNA, creation of pigs free of endogenous retroviruses, and mutations in the gene encoding an innate sensor of RNA in children with severe viral respiratory disease.

Hosts: Vincent RacanielloAlan Dove, Rich Condit, and Kathy Spindler

Guest: Erin Garcia

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Links for this episode

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Erin - What If? by Randall Monroe
Rich - Art.Science.Gallery (J. Haley Gillespie)
Kathy -
Astronomy photographer of the year shortlist
Alan - Upcoming Eclipses
Vincent - Ford Thunderbird Automatic Transmission Rebuild

Listener Pick

Bryan - Neuroscientists tricks journals

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Aug 20, 2017
TWiV 454: FGCU, Zika
01:47:59

Sharon and Scott return to TWiV for a Zika virus update, including their work on viral evolution and spread, and whether pre-existing immunity to dengue virus enhances pathogenesis.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, and Kathy Spindler

Guests: Sharon Isern and Scott Michael

 

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Weekly Science Picks

Dickson - Industrial Scars
Kathy - Eclipse info by zipcode

Sharon - Michaela’s article in The Conversation
Scott - Signal P, PecaanPhameratorDNAmaster
Alan - The Eagle Whisperer” (and the Great Big Story channel)
Vincent - Bottle

Listener Pick

Kevin - Tenure track scientist bites the dust

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Aug 13, 2017
TWiV 453: Neurovirology with Diane Griffin
01:03:53

From the Vector-Borne Viruses Symposium in Hamilton, Montana, Dickson and Vincent speak with Diane Griffin about her career and her work on understanding viral infections of the central nervous system.

Hosts: Vincent Racaniello and Dickson Despommier

Guest: Diane Griffin

 

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This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv.

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Aug 06, 2017
TWiV 452: Kiss that frog
01:52:39

Lynda Coughlan joins the weekly virtual bus companions for a discussion of a host defense peptide from frogs that destroys influenza virus, and mouse models for acute and chronic hepacivirus infection.

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler

Guest: Lynda Coughlan

 

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Links for this episode

Weekly Science Picks

Kathy - US rivers as subway map
Lynda - No Time to Lose: A Life in Pursuit of Deadly Viruses by Peter Piot
Alan
- Apollo-era computers found in dead engineer’s basement
Vincent - 110 NFL Brains, research article in JAMA and The best science is often accidental

Listener Pick

Stig - Security Now! and The Gene by Siddhartha Mukherjee
Ricardo - John Oliver on Vaccines

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Jul 29, 2017
TWiV 451: Expectorate the unexpected
01:44:05

The TWiV scientists reveal that mosquitoes transmit different West Nile virus populations with each blood meal, only to have the diversity purged in a bird host.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

 

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Links for this episode

Weekly Science Picks

Kathy - Approaching Jupiter and Michigan parents about vaccination
Rich - Math Limericks from Futility Closet
Alan
- NASA flyover of Pluto
Vincent - Talk show host nominated as USDA chief scientist

Listener Pick

Neil - These smart girls are here to debunk anti-vaxxer nonsense
John - John Sever AMA

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Jul 23, 2017
TWiV 450: Ben tenOever and RNA out
01:35:33

Ben tenOever joins the TWiVoli to discuss the evolution of RNA interference and his lab's finding that RNAse III nucleases, needed for the maturation of cellular RNAs, are an ancient antiviral RNA recognition platform in all domains of life.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, Rich Condit, and Kathy Spindler

Guest: Ben tenOever

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Links for this episode

Weekly Science Picks

Ben - Invisible Invaders by Peter Radetsky
Kathy -
ASV 2017 Virolympics Crossword solved (pdf) and National Museum of the Air Force
Rich - Columbia river gorge and Undaunted Courage by Stephen Ambrose
Dickson -
All the World's Earthquakes
Alan
- Map of Roman roads
Vincent - Brain atlas of fly behavior

Listener Pick

Rob - Vaccinate Your Kids and Charles Darwin Natural Selection
Islam - Self-assembling virus and Virus Patterns

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Jul 16, 2017
TWiV 449: The sound of non-silencing

The TWiV Council explores the finding that facial appearance affects science communication, and evidence that RNA interference confers antiviral immunity in mammalian cells.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, and Kathy Spindler

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Links for this episode

Weekly Science Picks

Kathy - ASV 2017 Virolympics Crossword (pdf)
Dickson -
The Visible Mouse
Alan
- Is profitable publishing bad for science?
Vincent - Locally Sourced Science

Listener Pick

Neva - Michael Summers interview and Virus coloring book

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Jul 09, 2017