One prescription drug is keeping some addicts from dying. So why isn’t it more widespread? A story of regulation, stigma, and the potentially fatal faith in abstinence.

How pharma greed, government subsidies, and a push to make pain the “fifth vital sign” kicked off a crisis that costs $80 billion a year and has killed hundreds of thousands of Americans.

We all like to throw around terms that describe human behavior — “bystander apathy” and “steep learning curve” and “hard-wired.” Most of the time, they don’t actually mean what we think they mean. But don’t worry — the experts are getting it wrong, too.

There is strong evidence that exercise is wildly beneficial. There is even stronger evidence that most people hate to exercise. So if a pill could mimic the effects of working out, why wouldn’t we want to take it?

In a special holiday episode, Stephen Dubner and Angela Duckworth take turns asking each other questions about charisma, wealth vs. intellect, and (of course) grit.

A year ago, nobody was taking Andrew Yang very seriously. Now he is America’s favorite entrepre-nerd, with a candidacy that keeps gaining momentum. This episode includes our Jan. 2019 conversation with the leader of the Yang Gang and a fresh interview recorded from the campaign trail in Iowa.

Every year, Americans short the I.R.S. nearly half a trillion dollars. Most ideas to increase compliance are more stick than carrot — scary letters, audits, and penalties. But what if we gave taxpayers a chance to allocate how their money is spent, or even bribed them with a thank-you gift?

Innovation experts have long overlooked where a lot of innovation actually happens. The personal computer, the mountain bike, the artificial pancreas — none of these came from some big R&D lab, but from users tinkering in their homes. Acknowledging this reality — and encouraging it — would be good for the economy (and the soul too).

There are a lot of barriers to changing your mind: ego, overconfidence, inertia — and cost. Politicians who flip-flop get mocked; family and friends who cross tribal borders are shunned. But shouldn’t we be encouraging people to change their minds? And how can we get better at it ourselves?

A recent outbreak of illness and death has gotten everyone’s attention — including late-to-the-game regulators. But would a ban on e-cigarettes do more harm than good? We smoke out the facts.

For nearly a decade, governments have been using behavioral nudges to solve problems — and the strategy is catching on in healthcare, firefighting, and policing. But is that thinking too small? Could nudging be used to fight income inequality and achieve world peace? Recorded live in London, with commentary from Andy Zaltzman (The Bugle).

It’s an acutely haphazard way of paying workers, and yet it keeps expanding. We dig into the data to find out why.

Do economic sanctions work? Are big democracies any good at spreading democracy? What is the root cause of terrorism? It turns out that data analysis can help answer all these questions — and make better foreign-policy decisions. Guests include former Department of Defense officials Chuck Hagel and Michèle Flournoy and Chicago Project on Security and Threats researchers Robert Pape and Paul Poast. Recorded live in Chicago; Steve Levitt is co-host.